2-hydroxypropane-1,3-diyl bis(2-((tert-butoxycarbonyl)amino)acetate) | 1228443-16-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-hydroxypropane-1,3-diyl bis(2-((tert-butoxycarbonyl)amino)acetate)
• 英文别名: 1,3-bis-{2'-N-(t-butoxycarbonyl)aminoacetoxy}propane-2-ol；[2-Hydroxy-3-[2-[(2-methylpropan-2-yl)oxycarbonylamino]acetyl]oxypropyl] 2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate
• CAS: 1228443-16-0
• 化学式: C₁₇H₃₀N₂O₉
• 分子量: 406.433
• InChiKey: FYNANNVEAURYQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  28
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  150
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  2-hydroxypropane-1,3-diyl bis(2-((tert-butoxycarbonyl)amino)acetate) 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 、 三氟乙酸 作用下， 生成 2-(2-((9Z,12Z)-octadeca-9,12-dienamido)acetoxy)propane-1,3-diyl bis(2-aminoacetate)
  参考文献：
  名称：

  CATIONIC LIPIDS AND USES THEREOF

  摘要：

  Disclosed herein is directed to cationic lipids and lipid nanoparticles (LNPs) comprising the same for encapsulating and delivering active pharmaceutical ingredients (API) (e.g., nucleic acids) into cells. The cationic lipid has the structure of formula (I), wherein, at least one of X and Y is —(C═O)CH 2 NH 2 , and the other X, Y, and Z are independently selected from the group consisting of —(C═O)CH 2 NH 2 , —[C═O)CH 2 NH](C═O)R 1 , —(C═O)R 1 , and H, wherein R 1 is C 9-25 alkyl, or C 13-21 alkenyl. Also encompasses herein is a method of treating a disease in a subject in need thereof, comprising administering an effective amount of the LNPs set forth above to the subject.

  公开号：

  US20240189235A1
• 作为产物：
  描述：

  BOC-甘氨酸 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 生成 2-hydroxypropane-1,3-diyl bis(2-((tert-butoxycarbonyl)amino)acetate)
  参考文献：
  名称：

  CATIONIC LIPIDS AND USES THEREOF

  摘要：

  Disclosed herein is directed to cationic lipids and lipid nanoparticles (LNPs) comprising the same for encapsulating and delivering active pharmaceutical ingredients (API) (e.g., nucleic acids) into cells. The cationic lipid has the structure of formula (I), wherein, at least one of X and Y is —(C═O)CH 2 NH 2 , and the other X, Y, and Z are independently selected from the group consisting of —(C═O)CH 2 NH 2 , —[C═O)CH 2 NH](C═O)R 1 , —(C═O)R 1 , and H, wherein R 1 is C 9-25 alkyl, or C 13-21 alkenyl. Also encompasses herein is a method of treating a disease in a subject in need thereof, comprising administering an effective amount of the LNPs set forth above to the subject.

  公开号：

  US20240189235A1

文献信息

• Novel chemoenzymatic methodology for the regioselective glycine loading on polyhydroxy compounds
  作者：Shashwat Malhotra、Marcelo Calderón、Ashok K. Prasad、Virinder S. Parmar、Rainer Haag

  DOI：10.1039/b927021c

  日期：——

  In the present work, we have developed a highly efficient temperature-dependent chemo-enzymatic methodology for the regioselective synthesis of novel esters of glycerol, G1 tri-glycerol dendrons and related esters for the first time using 4-nitrophenyl 2-(tert-butoxycarbonyl)acetate (Boc-gly-Ph-pNO2) (2) as the acylating agent. This methodology offers efficient and controlled loading of amino acid (glycine) on polyhydroxy compounds.

  在本研究中，我们首次开发了一种高效的温度依赖性化学酶法，用于区选择性合成新型甘油酯、G1三甘油树枝状分子及相关酯类，采用4-硝基苯基2-(叔丁氧羰基)乙酸酯（Boc-gly-Ph-pNO2）（2）作为酰基化试剂。该方法提供了对氨基酸（甘氨酸）在多羟基化合物上的高效和可控加载。
• CATIONIC LIPIDS AND USES THEREOF
  申请人：MELLO BIOTECH TAIWAN CO., LTD.

  公开号：US20240189235A1

  公开（公告）日：2024-06-13

  Disclosed herein is directed to cationic lipids and lipid nanoparticles (LNPs) comprising the same for encapsulating and delivering active pharmaceutical ingredients (API) (e.g., nucleic acids) into cells. The cationic lipid has the structure of formula (I), wherein, at least one of X and Y is —(C═O)CH 2 NH 2 , and the other X, Y, and Z are independently selected from the group consisting of —(C═O)CH 2 NH 2 , —[C═O)CH 2 NH](C═O)R 1 , —(C═O)R 1 , and H, wherein R 1 is C 9-25 alkyl, or C 13-21 alkenyl. Also encompasses herein is a method of treating a disease in a subject in need thereof, comprising administering an effective amount of the LNPs set forth above to the subject.