(4S)-4-(4-bromopyridin-2-yl)-4,6-dimethyl-1,3-thiazin-2-amine | 1404489-30-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (4S)-4-(4-bromopyridin-2-yl)-4,6-dimethyl-1,3-thiazin-2-amine
• CAS: 1404489-30-0
• 化学式: C₁₁H₁₂BrN₃S
• 分子量: 298.206
• InChiKey: VTTGCZRLTOPJQH-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  76.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (4S)-4-(4-bromopyridin-2-yl)-4,6-dimethyl-1,3-thiazin-2-amine 在 4-二甲氨基吡啶 、 tris-(dibenzylideneacetone)dipalladium(0) 、 甲酸 、 caesium carbonate 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 反应 3.83h， 生成 N-[2-[(4S)-2-amino-4,6-dimethyl-1,3-thiazin-4-yl]pyridin-4-yl]-5-cyanopyridine-2-carboxamide
  参考文献：
  名称：

  EP2703401

  摘要：

  公开号：
• 作为产物：
  描述：

  (4S)-4-Amino-4-(4-bromopyridin-2-yl)pentan-2-one 在 一水合肼 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 2.33h， 生成 (4S)-4-(4-bromopyridin-2-yl)-4,6-dimethyl-1,3-thiazin-2-amine
  参考文献：
  名称：

  EP2703401

  摘要：

  公开号：

文献信息

• PYRIDINE DERIVATIVE AND BACE-1 INHIBITOR CONTAINING SAME
  申请人：Shionogi & Co., Ltd.

  公开号：EP2703401A1

  公开（公告）日：2014-03-05

  The present invention provides a compound of formula (I): wherein ring B is substituted or unsubstituted carbocycle or heterocycle, R1 is substituted or unsubstituted alkyl or the like, R2a and R2b are each independently hydrogen, substituted or unsubstituted alkyl or the like, R3, R4a and R4b are each independently hydrogen, halogen, substituted or unsubstituted alkyl or the like, a dashed line represents a presence or absence of a bond, R5 is hydrogen, substituted or unsubstituted alkyl or the like, R6 is halogen, hydroxy, substituted or unsubstituted alkyl or the like, p is an integer of 0 to 3, or a pharmaceutically acceptable salt thereof which has an effect of inhibiting amyloid β production, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid β proteins.

  本发明提供了一种式 (I) 的化合物： 其中环 B 是取代或未取代的碳环或杂环、 R1 是取代或未取代的烷基或类似物、 R2a 和 R2b 各自独立地为氢、取代或未取代的烷基或类似物、 R3、R4a 和 R4b 各自独立地为氢、卤素、取代或未取代的烷基或类似物，虚线表示存在或不存在键、 R5 是氢、取代或未取代的烷基或类似物、 R6 是卤素、羟基、取代或未取代的烷基或类似物、 p 是 0 至 3 的整数、 或其药学上可接受的盐，该盐具有抑制淀粉样蛋白 β 生成的作用，特别是抑制 BACE1 的作用，可用作治疗或预防由淀粉样蛋白 β 生成、分泌和/或沉积诱发的疾病的药物。
• PYRIDINE DERIVATIVES AND A PHARMACEUTICAL COMPOSITION FOR INHIBITING BACE1 CONTAINING THEM
  申请人：Tada Yukio

  公开号：US20140235626A1

  公开（公告）日：2014-08-21

  The present invention provides a compound of formula (I): wherein ring B is substituted or unsubstituted carbocycle or heterocycle, R 1 is substituted or unsubstituted alkyl or the like, R 2a and R 2b are each independently hydrogen, substituted or unsubstituted alkyl or the like, R 3 , R 4a and R 4b are each independently hydrogen, halogen, substituted or unsubstituted alkyl or the like, a dashed line represents a presence or absence of a bond, R 5 is hydrogen, substituted or unsubstituted alkyl or the like, R 6 is halogen, hydroxy, substituted or unsubstituted alkyl or the like, p is an integer of 0 to 3, or a pharmaceutically acceptable salt thereof which has an effect of inhibiting amyloid β production, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid β proteins.
• EP2703401
  申请人：——

  公开号：——

  公开（公告）日：——