(+/-)-5'-carboxy-spiro[imidazolidine-4,2'-indane]-2,5-dione | 766540-45-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: (+/-)-5'-carboxy-spiro[imidazolidine-4,2'-indane]-2,5-dione
• 英文别名: 2',5'-Dioxospiro[1,3-dihydroindene-2,4'-imidazolidine]-5-carboxylic acid
• CAS: 766540-45-8
• 化学式: C₁₂H₁₀N₂O₄
• 分子量: 246.222
• InChiKey: LBLCXWVTGMFIAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  95.5
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二氧化碳 在 乙基溴化镁 、 叔丁基锂 作用下， 以 四氢呋喃 、 正戊烷 为溶剂， 反应 0.59h， 生成 (+/-)-5'-carboxy-spiro[imidazolidine-4,2'-indane]-2,5-dione
  参考文献：
  名称：

  WO2007/16087

  摘要：

  公开号：

文献信息

• [EN] PIPERIDINE CARBOXAMIDE SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES SPIROHYDANTOÏNES DES RÉCEPTEURS CGRP DE TYPE CARBOXAMIDE DE PIPÉRIDINE
  申请人：MERCK SHARP & DOHME

  公开号：WO2012129014A1

  公开（公告）日：2012-09-27

  The present invention is directed to piperidinone carboxamide spirohydantoin derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

  本发明涉及吡啶酮羧酰胺螺内酰脲衍生物，这些衍生物是CGRP受体拮抗剂，并且在治疗或预防涉及CGRP的疾病，如偏头痛等方面具有用途。该发明还涉及包含这些化合物的药物组合物，以及在预防或治疗涉及CGRP的这类疾病中使用这些化合物和组合物。
• Benodiazepine spirohydantoin cgrp receptor antagonists
  申请人：Bell M. Ian

  公开号：US20060189600A1

  公开（公告）日：2006-08-24

  The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

  本发明涉及一种针对CGRP受体的拮抗剂化合物，可用于治疗或预防CGRP参与的疾病，如头痛、偏头痛和群集性头痛。该发明还涉及包含这些化合物的药物组合物以及在预防或治疗CGRP参与的这些疾病中使用这些化合物和组合物的用途。
• Carboxamide spirohydantoin cgrp receptor antagonists
  申请人：Bell M. Ian

  公开号：US20070111982A1

  公开（公告）日：2007-05-17

  The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

  本发明涉及一种对CGRP受体具有拮抗作用的化合物，可用于治疗或预防CGRP参与的疾病，如头痛、偏头痛和集群头痛。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗CGRP参与的这些疾病中使用这些化合物和组合物的用途。
• Heterocyclic benzodiazepine cgrp receptor antagonists
  申请人：Williams Theresa M.

  公开号：US20090105228A1

  公开（公告）日：2009-04-23

  Compounds of formula I: (where variables R 2 , R 7 , D, W, X, Y and Z are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

  公式I的化合物：（其中变量R2，R7，D，W，X，Y和Z如本文所述），它们是CGRP受体的拮抗剂，并且可用于治疗或预防与CGRP有关的疾病，如偏头痛。本发明还涉及包含这些化合物的制药组合物以及使用这些化合物和组合物预防或治疗CGRP参与的这些疾病。
• [EN] BENODIAZEPINE SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES BENODIAZEPINE SPIROHYDANTOIN DES RECEPTEURS DE CGRP
  申请人：MERCK & CO INC

  公开号：WO2004087649A3

  公开（公告）日：2005-06-30