(S)-4-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(4-hydroxy-benzyl)-4-oxo-butyric acid | 312689-80-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (S)-4-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(4-hydroxy-benzyl)-4-oxo-butyric acid
• CAS: 312689-80-8
• 化学式: C₂₁H₂₁NO₆
• 分子量: 383.401
• InChiKey: IGCXDSVSNIXSNJ-DLBZAZTESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.62
• 重原子数：
  28.0
• 可旋转键数：
  7.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  104.14
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  (S)-4-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(4-hydroxy-benzyl)-4-oxo-butyric acid 在 过氧化氢,锂盐(1:1) 、 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 生成 (S)-2-{4-[2-(5-Ethyl-pyridin-2-yl)-ethoxy]-benzyl}-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid
  参考文献：
  名称：

  Hybridization of non-sulfonylurea insulin secretagogue and thiazolidinedione-derived insulin sensitizer

  摘要：

  Hybrid compounds of non-sulfonylurea insulinotropic agents and thiazolidinedione-derived insulin-sensitizing agents were designed and synthesized. The benzylidenesuccinic acid derivative 24 was equal both to nateglinide in potency of insulin-releasing activity and to pioglitazone in insulin-sensitizing activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00491-1
• 作为产物：
  描述：

  (S)-4-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(4-hydroxy-benzyl)-4-oxo-butyric acid ethyl ester 在 三氟乙酸 作用下， 生成 (S)-4-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(4-hydroxy-benzyl)-4-oxo-butyric acid
  参考文献：
  名称：

  Hybridization of non-sulfonylurea insulin secretagogue and thiazolidinedione-derived insulin sensitizer

  摘要：

  Hybrid compounds of non-sulfonylurea insulinotropic agents and thiazolidinedione-derived insulin-sensitizing agents were designed and synthesized. The benzylidenesuccinic acid derivative 24 was equal both to nateglinide in potency of insulin-releasing activity and to pioglitazone in insulin-sensitizing activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00491-1