1-[5-(3,4-Dimethylphenyl)-2,3-diphenylpyrrol-1-yl]ethanone | 1532520-69-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1-[5-(3,4-Dimethylphenyl)-2,3-diphenylpyrrol-1-yl]ethanone
• 英文别名: 1-[5-(3,4-dimethylphenyl)-2,3-diphenylpyrrol-1-yl]ethanone
• CAS: 1532520-69-6
• 化学式: C₂₆H₂₃NO
• 分子量: 365.475
• InChiKey: MJSNOXGZJNLLJD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  22
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3',4'-dimethylacetophenone oxime 在 copper(l) iodide 、 copper diacetate 、 palladium diacetate 、 sodium hydrogensulfite 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 2-甲基-2-丁醇 、 1,2-二氯乙烷 为溶剂， 生成 1-[5-(3,4-Dimethylphenyl)-2,3-diphenylpyrrol-1-yl]ethanone
  参考文献：
  名称：

  Pd-Catalyzed Oxidative Coupling of Enamides and Alkynes for Synthesis of Substituted Pyrroles

  摘要：

  A novel and efficient palladium(II)-catalyzed alkenyl C-H activation oxidative annulation of enamides with alkynes for the synthesis of substituted pyrroles has been developed. The reaction tolerates a wide range of functional groups and is a reliable method for the synthesis of triaryl-substituted pyrroles in high yields.

  DOI：

  10.1021/ol403517p

文献信息

• Pd-Catalyzed Oxidative Coupling of Enamides and Alkynes for Synthesis of Substituted Pyrroles
  作者：Mi-Na Zhao、Zhi-Hui Ren、Yao-Yu Wang、Zheng-Hui Guan

  DOI：10.1021/ol403517p

  日期：2014.1.17

  A novel and efficient palladium(II)-catalyzed alkenyl C-H activation oxidative annulation of enamides with alkynes for the synthesis of substituted pyrroles has been developed. The reaction tolerates a wide range of functional groups and is a reliable method for the synthesis of triaryl-substituted pyrroles in high yields.