壬烷-1,5,9-三醇 | 1119-12-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 壬烷-1,5,9-三醇
• 英文名称: nonane-1,5,9-triol
• 英文别名: Nonantriol-(1,5,9)
• CAS: 1119-12-6
• 化学式: C₉H₂₀O₃
• 分子量: 176.256
• InChiKey: QJJPOBJBTPLMKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  壬烷-1,5,9-三醇 在 [ReOCl₃(PPh₃)₂] 2,4,6-三甲基吡啶 、 乙二醇 、 二甲基亚砜 作用下， 以 甲苯 为溶剂， 反应 3.0h， 以57%的产率得到1,7-二氧螺环-[5,5]十一烷
  参考文献：
  名称：

  在乙二醇的存在下，rh通过甲基亚砜的选择性rh催化氧化氧化仲醇，方便地一锅合成缩酮。

  摘要：

  [反应：参见正文]在乙二醇和回流的甲苯存在下，DMSO和催化剂ReOCl3（PPh3）2优先将仲醇氧化，生成相应的缩酮。反应是快速的，并且以非常好的产率进行。反应的副产物甲基硫化物和水很容易除去。没有观察到环氧化或其他常见的副反应。醇向被保护的缩酮衍生物的这种直接氧化转化应具有广泛的合成适用性。

  DOI：

  10.1021/ol990755e
• 作为产物：
  描述：

  2-(4-氯丁氧基)四氢吡喃 在 四氢呋喃 、 magnesium 、 甲酸乙酯 作用下， 生成 壬烷-1,5,9-三醇
  参考文献：
  名称：

  Crisan, Annales de Chimie (Cachan, France), 1956, vol. <13>1, p. 436,459

  摘要：

  DOI：

文献信息

• LIPID COMPOSITION
  申请人：FUJIFILM Corporation

  公开号：US20220273817A1

  公开（公告）日：2022-09-01

  An object of the present invention is to provide a lipid composition capable of achieving excellent nucleic acid delivery for a wide variety of nucleic acids. According to the present invention, there is provided a lipid composition containing a first lipid which is a lipid represented by Formula (1) or a salt thereof, sterols, and nucleic acid, in which a ratio of the number of moles of the first lipid in the lipid composition to the number of moles of sterols in the lipid composition is 0.300 or more and less than 1.299. In the formula, X represents —NR 1 — or —O—, R 1 represents a hydrogen atom, a hydrocarbon group, or the like, R 2 and R 3 each independently represent a hydrogen atom, a hydrocarbon group, or the like, R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , and R 12 each independently represent a hydrogen atom or an alkyl group, groups in any one or more pairs among R 4 and R 5 , R 10 and R 5 , R 5 and R 12 , R 4 and R 6 , R 5 and R 6 , R 6 and R 7 , R 6 and R 10 , R 12 and R 7 , and R 7 and R 8 may be linked to each other to form a 4- to 7-membered ring which may contain an O atom, a, b, c, and d are each independently represent an integer of 0 to 3, a+b is 1 or more, and c+d is 1 or more.

  本发明的目的是提供一种脂质组合物，能够实现对各种核酸的优异递送。根据本发明，提供了一种脂质组合物，其中包含第一脂质，该脂质是由式（1）或其盐所代表的脂质，固醇和核酸，其中第一脂质的摩尔数与固醇的摩尔数之比为0.300或更多，但小于1.299。在公式中，X代表—NR1—或—O—，R1代表氢原子、烃基或类似物，R2和R3各自独立地代表氢原子、烃基或类似物，R4、R5、R6、R7、R8、R9、R10、R11和R12各自独立地代表氢原子或烷基，在R4和R5、R10和R5、R5和R12、R4和R6、R5和R6、R6和R7、R6和R10、R12和R7以及R7和R8中的任意一对中，可以将其相互连接以形成4至7个成员的环，该环中可以含有一个O原子，a、b、c和d各自独立地代表0至3的整数，a+b为1或更多，c+d为1或更多。
• [EN] IONIZABLE AMINE LIPIDS AND LIPID NANOPARTICLES<br/>[FR] LIPIDES AMINÉS IONISABLES ET NANOPARTICULES LIPIDIQUES
  申请人：BEAM THERAPEUTICS INC

  公开号：WO2023121975A1

  公开（公告）日：2023-06-29

  The present disclosure describes compositions, preparations, nanoparticles (such as lipid nanoparticles), and/or nanomaterials and methods of their use.

  本公开介绍了组合物、制剂、纳米颗粒（如脂质纳米颗粒）和/或纳米材料及其使用方法。
• COMPOUND, SALT THEREOF AND LIPID PARTICLES
  申请人：FUJIFILM Corporation

  公开号：EP3805198A1

  公开（公告）日：2021-04-14

  An object of the present invention is to provide a compound or a salt thereof constituting lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids, and to provide lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids. According to an aspect of the present invention, a compound represented by Formula (1) or a salt thereof is provided. In the formula, X represents -NR1- or -O-, R1 represents a hydrogen atom, a hydrocarbon group, or the like, R2 and R3 each independently represent a hydrogen atom, a hydrocarbon group, or the like, R4, R5, R6, R7, R8, R9, R10, R11, and R12 each independently represent a hydrogen atom or an alkyl group, groups in any one or more pairs among R4 and R5, R10 and R5, R5 and R12, R4 and R6, R5 and R6, R6 and R7, R6 and R10, R12 and R7, and R7 and R8 may be linked to each other to form a 4- to 7-membered ring which may contain an O atom, a, b, c, and d are each independently represent an integer of 0 to 3, a + b is equal to or greater than 1, and c + d is equal to or greater than 1.

  本发明的目的是提供一种化合物或其盐类构成的脂质微粒，该脂质微粒可实现较高的核酸包封率和核酸的良好递送，并提供可实现较高的核酸包封率和核酸的良好递送的脂质微粒。根据本发明的一个方面，提供了一种由式（1）代表的化合物或其盐。 式中，X代表-NR1-或-O-，R1代表氢原子、烃基或类似物，R2和R3各自独立地代表氢原子、烃基或类似物，R4、R5、R6、R7、R8、R9、R10、R11和R12各自独立地代表氢原子或烷基、R4和R5之间任意一对或多对的基团、R10 和 R5、R5 和 R12、R4 和 R6、R5 和 R6、R6 和 R7、R6 和 R10、R12 和 R7 以及 R7 和 R8 中的任意一对或多对基团可彼此相连，形成可包含 O 原子的 4 至 7 元环，a、b、c 和 d 各自独立地代表 0 至 3 的整数，a + b 等于或大于 1，c + d 等于或大于 1。
• Anhydride-modified chitosan, method of preparation thereof, and fluids containing same
  申请人：——

  公开号：US20020098987A1

  公开（公告）日：2002-07-25

  The invention provides an organic diacid anhydride-modified chitosan containing a polar additive comprising water soluble compounds containing one or more hydroxyl groups or one or more amino groups, including compounds containing both hydroxyl and amine groups, having a molecular weight less than about 2000, preferably less than about 1000. The invention also provides fluids useful in various well drilling and servicing operations comprising an alkaline aqueous liquid containing an organic diacid anhydride, chitosan, and the polar additive therein, as well as a method of drilling wells therewith.

  本发明提供了一种含有极性添加剂的有机二酸酐改性壳聚糖，极性添加剂包括含有一个或多个羟基或一个或多个氨基的水溶性化合物，包括同时含有羟基和胺基的化合物，分子量小于约2000，最好小于约1000。本发明还提供了可用于各种钻井和维修作业的液体，其中包括一种含有有机二酸酐、壳聚糖和极性添加剂的碱性含水液体，以及用其钻井的方法。
• Multialkylation of Aqueous Ammonia with Alcohols Catalyzed by Water-Soluble Cp*Ir−Ammine Complexes
  作者：Ryoko Kawahara、Ken-ichi Fujita、Ryohei Yamaguchi

  DOI：10.1021/ja107274w

  日期：2010.11.3

  Novel water-soluble Cp*Ir-ammine complexes have been synthesized, and a new and highly atom-economical system for the synthesis of organic amines using aqueous ammonia as a nitrogen source has been developed. With a water-soluble and air-stable Cp*Ir-ammine catalyst, [Cp*Ir(NH3)(3)][1](2), a variety of tertiary and secondary amines were synthesized by the multialkylation of aqueous ammonia with theoretical equivalents of primary and secondary alcohols. The catalyst could be recycled by a facile procedure maintaining high activity. A one-flask synthesis of quinolizidine starting with 1,5,9-nonanetriol was also demonstrated. This new catalytic system would provide a practical and environmentally benign methodology for the synthesis of various organic amines.