geraldone | 21583-32-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: geraldone
• 英文别名: 7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)chromen-4-one
• CAS: 21583-32-4
• 化学式: C₁₆H₁₂O₅
• 分子量: 284.268
• InChiKey: OUMMPAFEQHTYIZ-UHFFFAOYSA-N

物化性质

• 熔点：
  206-207 °C (decomp)
• 沸点：
  534.5±50.0 °C(Predicted)
• 密度：
  1.420±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  高紫柳查尔酮 生成 geraldone
  参考文献：
  名称：

  NABAEI-BIDHENDI, G.;BANNERJEE, N. R., J. INDIAN CHEM. SOC., 67,(1990) N, C. 43-45

  摘要：

  DOI：

文献信息

• Compounds for immunopotentiation
  申请人：Valiante Nicholas

  公开号：US20100226931A1

  公开（公告）日：2010-09-09

  Methods of stimulating an immune response and treating patients responsive thereto with 3,4-di(1H-indol-3-yl)-1H-pyrrole-2,5-diones, staurosporine analogs, derivatized pyridazines, chromen-4-ones, indolinones, quinazolines, nucleoside analogs, and other small molecules are disclosed. In a preferred embodiment benzopyrimidine derivatives such as ZD-6474, MLN-518, lapatinib, gefitinib or erlotinib are used.

  本发明公开了刺激免疫反应和治疗对3,4-二（1H-吲哚-3-基）-1H-吡咯-2,5-二酮，链霉菌素类似物，衍生的吡啶并嗪，香豆素-4-酮，吲哚酮，喹唑啉，核苷类似物和其他小分子具有响应性的患者。在一种优选实施方式中，使用苯并嘧啶衍生物，例如ZD-6474，MLN-518，拉帕替尼，吉非替尼或厄洛替尼。
• Nodulation inducing factors
  申请人：LUBRIZOL GENETICS INC.

  公开号：EP0245931A2

  公开（公告）日：1987-11-19

  Nodulation gene-inducing factors have been isolated and identified. A number of substituted flavones, some of which are components of exudates and extracts of leguminous plants, have been found to induce expression of certain nodulation genes in Rhizobium strains. Three components of clover extract 7,4ʹ-dihydroxyflavone, 7,4ʹ-­dihydroxy-3ʹ-methoxyflavone, and 4ʹ-hydroxy-7-methoxyflavone have been identified as nodulation inducers of certain Rhizobium trifolii nod genes. A number of other flavanoids including flavones, flavanones, flavanols and dihydroflavanols, not necessarily found in legume exudates, were also found to induce expression of certain nodulation genes.

  已经分离并确定了结核基因诱导因子。已发现一些取代的黄酮（其中一些是豆科植物渗出物和提取物的成分）能诱导根瘤菌株中某些结核基因的表达。三叶草提取物中的三种成分 7,4ʹ-二羟基黄酮、7,4ʹ-二羟基-3ʹ-甲氧基黄酮和 4ʹ-羟基-7-甲氧基黄酮已被确定为三叶草根瘤菌（Rhizobium trifolii）某些芽接基因的芽接诱导剂。还发现其他一些黄酮类化合物，包括黄酮、黄烷酮、黄烷醇和二氢黄烷醇，不一定存在于豆科植物的渗出液中，但也能诱导某些结核基因的表达。
• Patonay, Tamas; Molnar, Denes; Muranyi, Zoltan, Bulletin de la Societe Chimique de France, 1995, vol. 132, # 2, p. 233 - 242
  作者：Patonay, Tamas、Molnar, Denes、Muranyi, Zoltan

  DOI：——

  日期：——
• Discovery of lesser known flavones as inhibitors of NF-κB signaling in MDA-MB-231 breast cancer cells—A SAR study
  作者：K. Amrutha、Pandurangan Nanjan、Sanu K. Shaji、Damu Sunilkumar、K. Subhalakshmi、Lakshmi Rajakrishna、Asoke Banerji

  DOI：10.1016/j.bmcl.2014.07.093

  日期：2014.10

  Seventeen flavonoids with different substitutions were evaluated for inhibition of nuclear factor-kappa B (NF-kappa B) signaling in the invasive breast cancer cell line MDA-MB-231. They were screened using an engineered MDA-MB-231 cell line reporting NF-kappa B activation. The modulation of expression of two NF-kappa B regulated genes involved in tumorigenesis, matrix metalloproteinase-9 (MMP-9), and cyclooxygenase-2 (COX-2) were also analyzed in these cells. Among the compounds tested, all except gossypetin and quercetagetin inhibited the activation of NF-kappa B, and the expression of MMP-9 and COX-2 to different degree. Methylated flavone, chrysoeriol (luteolin-3'-methylether), was found to be the most potent inhibitor of MMP-9 and COX-2 expressions. The effect of chrysoeriol on cell proliferation, cell cycle, apoptosis and metastasis was analyzed by established methods. Chrysoeriol caused cell cycle arrest at G2/M and inhibited migration and invasion of MDA-MB-231 cells. The structure-activity relations amongst the flavonoids as NF-kappa B signaling inhibitors was studied. The study indicates differences between the actions of various flavonoids on NF-kappa B activation and on the biological activities of breast cancer cells. Flavones in general, were more active than the corresponding flavonols. (C) 2014 Elsevier Ltd. All rights reserved.
• Peroxidase from Cell Cultures of Cassia didymobotrya: A Review and Comparison with Horseradish Peroxidase
  作者：Giuliano Delle Monache、Bruno Botta、Paola Ricciardi、Alberto Vitali、Vittorio Vinciguerra、Carlos Garcia

  DOI：10.3987/com-98-s(h)71

  日期：——