(2-amino-4,6-dimethyl-pyridin-3-yl)-methanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (2-amino-4,6-dimethyl-pyridin-3-yl)-methanol
• 英文别名: (2-Amino-4,6-dimethyl-[3]pyridyl)-methanol；(2-Amino-4,6-dimethylpyridin-3-yl)methanol
• 化学式: C₈H₁₂N₂O
• 分子量: 152.196
• InChiKey: BCOLWSRUTHYWSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  59.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2-amino-4,6-dimethyl-pyridin-3-yl)-methanol 在 氯化亚砜 作用下， 反应 1.0h， 以98%的产率得到3-chloromethyl-4,6-dimethyl-pyridin-2-ylamine hydrochloride
  参考文献：
  名称：

  Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors

  摘要：

  Tumor cells extensively utilize the pentose phosphate pathway for the synthesis of ribose. Transketolase is a key enzyme in this pathway and has been suggested as a target for inhibition in the treatment of cancer. In a pharmacodynamic study, nude mice with xenografted HCT-116 tumors were dosed with 1 ('N3'-pyridyl thiamine'; 3-(6-methyl-2-amino-pyridin-3-ylmethyl)-5-(2-hydroxyethyl)-4-methyl-thiazol-3-ium chloride hydrochloride), an analog of thiamine, the co-factor of transketolase. Transketolase activity was almost completely suppressed in blood, spleen, and tumor cells, but there was little effect on the activity of the other thiamine-utilizing enzymes alpha-ketoglutarate dehydrogenase or glucose-6-phosphate dehydrogenase. Synthesis and SAR of transketolase inhibitors is described. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.11.101
• 作为产物：
  描述：

  2-Amino-4,6-dimethyl-3-pyridincarbonsaeure-ethylester 在 lithium aluminium tetrahydride 、 乙醚 作用下， 生成 (2-amino-4,6-dimethyl-pyridin-3-yl)-methanol
  参考文献：
  名称：

  Dornow; Hargesheimer, Chemische Berichte, 1953, vol. 86, p. 461,464

  摘要：

  DOI：

文献信息

• Prokineticin 1 receptor antagonists
  申请人：Coats Steven J.

  公开号：US20080269225A1

  公开（公告）日：2008-10-30

  The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders.

  本发明涉及某些化合物的新颖结构，其化学式为（I）：以及制备这些化合物、组合物、中间体和衍生物的方法，以及用于治疗促动素1或促动素1受体介导的疾病的方法。
• PROKINETICIN 1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN
  申请人：Flores Christopher M.

  公开号：US20110319400A1

  公开（公告）日：2011-12-29

  Disclosed are compounds, compositions and methods for treating pain, including inflammatory, visceral, and acute pain. Such compounds are represented by Formula (I) as follows: wherein A 1 , L 1 , D, and Q are defined herein.

  披露了用于治疗疼痛的化合物、组合物和方法，包括炎症性、内脏性和急性疼痛。这些化合物由以下式（I）表示： 其中A1、L1、D和Q在此处定义。
• PROKINETICIN 1 RECEPTOR ANTAGONISTS
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP1973886A2

  公开（公告）日：2008-10-01
• EP1976528A2
  申请人：——

  公开号：EP1976528A2

  公开（公告）日：2008-10-08
• Prokineticin 2 receptor antagonists
  申请人：Coats Steven J.

  公开号：US20080287445A1

  公开（公告）日：2008-11-20

  The present invention relates to certain novel compounds of Formula (I): and methods for the treatment of prokineticin 2 or prokinetin 2 receptor mediated disorders.