(E,E)-1-Methoxy-3,5-bis<2-(4-methoxyphenyl)ethenyl>benzol | 114468-38-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: (E,E)-1-Methoxy-3,5-bis<2-(4-methoxyphenyl)ethenyl>benzol
• 英文别名: 1-methoxy-3,5-bis[(E)-2-(4-methoxyphenyl)ethenyl]benzene
• CAS: 114468-38-1
• 化学式: C₂₅H₂₄O₃
• 分子量: 372.464
• InChiKey: OXBULGCZQYCXPO-YDFGWWAZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (E,E)-1-Methoxy-3,5-bis<2-(4-methoxyphenyl)ethenyl>benzol 在 碘 作用下， 以 苯 为溶剂， 以23%的产率得到3,5,11-Trimethoxybenzochrysen
  参考文献：
  名称：

  Noller, Klaus; Kosteyn, Frank; Meier, Herbert, Chemische Berichte, 1988, vol. 121, p. 1609 - 1616

  摘要：

  DOI：
• 作为产物：
  描述：

  3,5-二甲基苯甲醚 、 N-(4-甲氧亚苄基)苯胺 在 potassium tert-butylate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以51%的产率得到(E,E)-1-Methoxy-3,5-bis<2-(4-methoxyphenyl)ethenyl>benzol
  参考文献：
  名称：

  Noller, Klaus; Kosteyn, Frank; Meier, Herbert, Chemische Berichte, 1988, vol. 121, p. 1609 - 1616

  摘要：

  DOI：

文献信息

• Curcumin Derivatives
  申请人：DiMauro Thomas M.

  公开号：US20100087527A1

  公开（公告）日：2010-04-08

  The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.
• Methylated Curcumin-Resveratrol Hybrid Molecules for Treating Cancer
  申请人：DiMauro Thomas M.

  公开号：US20100292512A1

  公开（公告）日：2010-11-18

  Methylated curcumin-methoxystilbene hybrid molecules that have particular use in treating cancer.
• PHARMACEUTICAL COMPOSITION COMPRISING A CURCUMIN DERIVATIVE
  申请人：DiMauro Thomas M.

  公开号：US20130150628A1

  公开（公告）日：2013-06-13

  The present invention is directed to a pharmaceutical composition comprising:
• METHOD OF TREATING CANCER USING A CURCUMIN DERIVATIVE
  申请人：DePuy Synthes Products, LLC

  公开号：US20140163116A1

  公开（公告）日：2014-06-12

  The present invention is directed to treating cancer with a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I).
• INTRANSAL DELIVERY OF CURCUMIN
  申请人：DePuy Synthes Products, Inc.

  公开号：US20170224637A1

  公开（公告）日：2017-08-10

  The present invention is directed to the intranasal delivery of curcumin adapted so as to target the brain.