2-(4-formyl-2,6-dimethoxyphenoxy)acetamide | 871544-53-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-formyl-2,6-dimethoxyphenoxy)acetamide
• CAS: 871544-53-5
• 化学式: C₁₁H₁₃NO₅
• mdl: MFCD07352309
• 分子量: 239.228
• InChiKey: ZGJGNMYBRANSQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.272
• 拓扑面积：
  87.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(4-formyl-2,6-dimethoxyphenoxy)acetamide 、 2-((2,2-diethoxyethylamino)methyl)-6-ethoxyphenol 在 硫酸 溶剂黄146 、 sodium carbonate 作用下， 以 水 为溶剂， 反应 0.25h， 生成 2-(4-((7-ethoxy-8-hydroxyisoquinolin-4-yl)methyl)-2,6-dimethoxyphenoxy)acetamide
  参考文献：
  名称：

  [EN] SUBSTITUTED ISOQUINOLINES AND THEIR USE AS TUBULIN POLYMERIZATION INHIBITORS
  [FR] ISOQUINOLÉINES SUBSTITUÉES ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE POLYMÉRISATION DES TUBULINES

  摘要：

  本发明总体上涉及取代异喹啉及其作为微管蛋白聚合抑制剂的应用。特别是，本发明涉及具有有用的治疗活性的取代异喹啉，这些化合物在治疗方法、药物制造以及含有这些化合物的组合物中的应用。

  公开号：

  WO2011151423A1
• 作为产物：
  描述：

  2-溴乙酰胺 、 丁香醛 在 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以42%的产率得到2-(4-formyl-2,6-dimethoxyphenoxy)acetamide
  参考文献：
  名称：

  [EN] SUBSTITUTED ISOQUINOLINES AND THEIR USE AS TUBULIN POLYMERIZATION INHIBITORS
  [FR] ISOQUINOLÉINES SUBSTITUÉES ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE POLYMÉRISATION DES TUBULINES

  摘要：

  本发明总体上涉及取代异喹啉及其作为微管蛋白聚合抑制剂的应用。特别是，本发明涉及具有有用的治疗活性的取代异喹啉，这些化合物在治疗方法、药物制造以及含有这些化合物的组合物中的应用。

  公开号：

  WO2011151423A1

文献信息

• SUBSTITUTED ISOQUINOLINES AND THEIR USE AS TUBULIN POLYMERIZATION INHIBITORS
  申请人：Leblond Bertrand

  公开号：US20130131018A1

  公开（公告）日：2013-05-23

  The present invention relates generally to substituted isoquinolines and their use as tubulin polymerization inhibitors. In particular, the invention relates to substituted isoquinolines which possess useful therapeutic activity, use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds.

  本发明涉及替代异喹啉及其作为微管聚合抑制剂的用途。具体而言，本发明涉及具有有用治疗活性的替代异喹啉，这些化合物在治疗方法中的使用以及制药和含有这些化合物的组合物的制造。
• Bi-functional complexes and methods for making and using such complexes
  申请人：Gouliaev Alex Haahr

  公开号：US11225655B2

  公开（公告）日：2022-01-18

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

  本发明涉及一种合成双功能复合物的方法，该复合物包括分子部分和识别分子部分的识别寡核苷酸部分。根据本发明的合成方法的一部分优选在一种或多种有机溶剂中进行，此时包含可选保护标签或寡核苷酸标识符的新生双功能复合物与固体支持物相连接，合成方法的另一部分优选在适合于将寡核苷酸标签酶加到溶液中的新生双功能复合物的条件下进行。
• BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Nuevolution A/S

  公开号：EP2558577A1

  公开（公告）日：2013-02-20
• BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Gouliaev Alex Haahr

  公开号：US20130281324A1

  公开（公告）日：2013-10-24

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.
• [EN] BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES<br/>[FR] COMPLEXES BIFONCTIONNELS ET PROCÉDÉS DE FABRICATION ET D'UTILISATION DE TELS COMPLEXES
  申请人：NUEVOLUTION AS

  公开号：WO2011127933A1

  公开（公告）日：2011-10-20

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.