α-methoxychalcone | 73968-06-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: α-methoxychalcone
• 英文别名: a-Methoxychalcone；(Z)-2-methoxy-1,3-diphenylprop-2-en-1-one
• CAS: 73968-06-6
• 化学式: C₁₆H₁₄O₂
• 分子量: 238.286
• InChiKey: WEFOXJZPHOTXML-QINSGFPZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  α-methoxychalcone 以 1,4-二氧六环 为溶剂， 反应 75.0h， 生成 (E)-2-Methoxy-1,3-diphenyl-propenone
  参考文献：
  名称：

  Photolyse de cetones conjuguees heterosubstituees lineaires

  摘要：

  DOI：

  10.1016/0040-4020(79)88013-8
• 作为产物：
  描述：

  (Z)-2-hydroxy-1,3-diphenylprop-2-en-1-one 、 硫酸二甲酯 生成 α-methoxychalcone
  参考文献：
  名称：

  TEUBER H.-J.; BADER H. J.; SCHULTZ G., J. LIEBIGS ANN. CHEM., 1977, NO

  摘要：

  DOI：

文献信息

• ANTI-INVASIVE COMPOUNDS
  申请人：Universiteit Gent

  公开号：US20150011620A1

  公开（公告）日：2015-01-08

  The present invention relates to the field of anti-invasive compounds and methods for predicting the anti-invasive activity of said compounds, as well as their use in the prevention and/or treatment of diseases associated with undesired cell invasion; in particular, this invention relates to the field of anti-invasive chalcone-like compounds.

  本发明涉及抗侵袭化合物领域，以及预测该类化合物抗侵袭活性的方法，以及它们在预防和/或治疗与不受欢迎的细胞侵袭相关的疾病中的用途；特别是，本发明涉及抗侵袭的类似香豆素化合物领域。
• METHODS OF DESIGNING, PREPARING, AND USING NOVEL PROTONOPHORES
  申请人：Martineau Louis C.

  公开号：US20140135359A1

  公开（公告）日：2014-05-15

  The present invention provides a computer-assisted method of generating a protonophore requiring the use of a computer including a processor. The method includes: designing the protonophore, calculating, using the processor, an estimated protonophoric activity; producing the protonophore if the estimated protonophoric activity corresponds to an U 50 of about 20 μM or less; and determining the uncoupling activity of the protonophore. The present invention also provides novel protonophores that meet the above requirement and their methods of use.

  本发明提供了一种利用计算机辅助的方法来生成需要使用处理器的质子载体。该方法包括：设计质子载体，使用处理器计算估计的质子载体活性；如果估计的质子载体活性对应于大约20微米或更少的U50，则生产质子载体；并确定质子载体的解耦活性。本发明还提供了符合上述要求的新型质子载体及其使用方法。
• Catalytic dehydrogenation process for the preparation of
  申请人：American Cyanamid Company

  公开号：US04014896A1

  公开（公告）日：1977-03-29

  There is provided a process for the preparation of 3,5-disubstituted pyrazoles which involves: A. the reaction of a methyl ketone, such as acetophenone or an appropriate derivative thereof, with an appropriate aldehyde, such as benzaldehyde in the presence of base to form a 1,3-disubstituted .alpha.,.beta.-unsaturated ketone, such as chalcone or a substituted chalcone, B. the acidification of said .alpha.,.beta.-unsaturated ketone, followed by treatment of the acidified reaction mixture with hydrazine to form a disubstituted pyrazoline, and C. the catalytic dehydrogenation of said pyrazoline to yield the desired 3,5-disubstituted pyrazole.

  提供了一种制备3,5-二取代吡唑的过程，包括：A. 甲基酮（如苯乙酮或适当的衍生物）与适当的醛（如苯甲醛）在碱的存在下发生反应，形成1,3-二取代的α，β-不饱和酮（如查尔酮或取代查尔酮），B. 酸化所述的α，β-不饱和酮，然后用肼处理酸化的反应混合物，形成二取代吡唑啉，以及C. 催化脱氢所述的吡唑啉，得到所需的3,5-二取代吡唑。
• PHOTOLABILE PRO-FRAGRANCES
  申请人：Henkel AG & Co. KGaA

  公开号：US20150099809A1

  公开（公告）日：2015-04-09

  Many fragrances that provide a scent of freshness tend to be highly volatile and are therefore not very economical when used in typical applications such as washing or cleaning processes, so they have to be used in relatively large quantities to be able to produce adequate effects. The disclosed photolabile pro-fragrances provide a much longer-lasting sense of fragrance, in particular with a scent of freshness, when used in typical applications, thus allowing said fragrances to be used efficiently.

  许多提供清新气味的香料往往具有高挥发性，因此在典型的应用中，如洗涤或清洁过程中使用时并不经济，因此必须使用相对大量的量才能产生足够的效果。所公开的光敏感前香料提供了更持久的香味感，特别是在典型的应用中具有清新的香味，从而使得这些香料能够有效地使用。
• METHOXYCHALCONE DERIVATIVES AND USES THEREOF
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US20210347724A1

  公开（公告）日：2021-11-11

  Methoxychalone derivatives with anti-cancer activity are provided.

  提供具有抗癌活性的甲氧基胆烷衍生物。