sodium cyclohexylpropanoate | 85454-69-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: sodium cyclohexylpropanoate
• 英文别名: Sodium;3-cyclohexylpropanoate
• CAS: 85454-69-9
• 化学式: C₉H₁₅O₂*Na
• 分子量: 178.207
• InChiKey: YMHXCERJCWPLNU-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  40.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-环己基丙酸 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 8.0h， 生成 sodium cyclohexylpropanoate
  参考文献：
  名称：

  Effects of Structure Variation on Solution Properties of Hydrotropes: Phenyl versus Cyclohexyl Chain Tips

  摘要：

  The physicochemical behavior of the phenyl-n-alkanoate (PhenCx) and cyclohexyl-n-alkanoate (CyclohexCx) series has been investigated, supporting previous work on the understanding of hydrotropes (Hopkins Hatzopoulos, M.; Eastoe, J.; Dowding, P.J.; Rogers, S. E.; Heenan, R; Dyer, R. Langmuir 2011, 27, 12346-12353). Electrical conductivity, surface tension, H-1 NMR, and small-angle neutron scattering (SANS) were used to study adsorption and aggregation in terms of critical aggregation concentration (cac). The PhenCx series exhibited very similar d log(cac)/dn to n-alkylbenzoates (CnBenz), exhibiting two branches of behavior, with a common inflection point at four linear carbons, whereas the CyclohexCx series showed no break point. Electrical conductivity and H-1 NMR concentration scans indicate a difference in physicochemical behavior between higher and lower homologues in both the PhenCx and CyclohexCx series. Surface tension measurements with compounds belonging to either group gave typical Gibbs adsorption profiles, having d log(cac)/dn curves consistent with limiting headgroup areas in the region of (35-55 angstrom(2)) indicating monolayer formation. SANS profiles showed no evidence for aggregates below the electrical conductivity determined cac values, inferring an "on-off" mode of aggregation. Analyses of SANS profiles was consistent with charged ellipsoidal aggregates, persisting from lower through to higher homologues in both the PhenCx and CyclohexCx series.

  DOI：

  10.1021/la301222m
• 作为试剂：
  描述：

  3-cyclohexyl-propionic acid anhydride 、 对硝基苯甲醛 在 sodium cyclohexylpropanoate 作用下， 生成 2-cyclohexylmethyl-3t-(4-nitro-phenyl)-acrylic acid
  参考文献：
  名称：

  The Preparation of Some Iodinated Aminophenylalkanoic Acids

  摘要：

  DOI：

  10.1021/ja01179a048

文献信息

• BIODEGRADABLE POLYMERIC MATERIALS AND ARTICLES FABRICATED THEREFROM
  申请人：AlliedSignal Inc.

  公开号：EP0541549A1

  公开（公告）日：1993-05-19
• US5541155A
  申请人：——

  公开号：US5541155A

  公开（公告）日：1996-07-30
• [EN] METHOD FOR ENHANCING THE BIODEGRADATION OF BIODEGRADABLE POLYMERIC MATERIALS AND OF ARTICLES FABRICATED THEREFROM
  申请人：ALLIED-SIGNAL INC.

  公开号：WO1991006681A1

  公开（公告）日：1991-05-16

  (EN) Method for assaying the biodegradability of a material by contacting the material with solution containing an enzyme and a surfactant.(FR) Procédé d'analyse de la biodégradabilité d'une matière, consistant à mettre cette dernière en contact avec une solution contenant une enzyme et un tensio-actif.
• [EN] BIODEGRADABLE POLYMERIC MATERIALS AND ARTICLES FABRICATED THEREFROM
  申请人：——

  公开号：WO1991006601A1

  公开（公告）日：1991-05-16

  [EN] A composition comprising one or more polymers and a filler which comprises one or more degradation enhancing materials which enhance the biodegradation of the polymers in association with one or more biodegradable safening materials which inhibit the enhancing activity of the enhancing materials whereby on biodegradation of the safening materials the activity is completely or partially restored.
  [FR] Composition comprenant un ou plusieurs polymères aisni qu'une matière de remplissage composée d'une ou de plusieurs matières facilitant la dégradation, lesquelles facilitent la biodégradation des polymères en association avec une ou plusieurs matières neutralisantes biodégradables inhibant l'activité favorable des matières facilitant la dégradation, de sorte que lors de la dégradation des matières neutralisantes, l'activité est complètement ou partiellement rétablie.
• [EN] ACIDS AND ACID SALTS AND THEIR USE IN DELIVERY SYSTEMS<br/>[FR] ACIDES ET SELS D'ACIDES ET LEUR UTILISATION DANS DES SYSTEMES D'ADMINISTRATION
  申请人：EMISPHERE TECHNOLOGIES, INC.

  公开号：WO1995028920A1

  公开（公告）日：1995-11-02

  (EN) The present invention relates to a delivery system, and in particular to carboxylic acids for use as a delivery system of sensitive agents such as bioactive peptides. The carboxyl acids and salts can form non-covalent mixtures with active biologically-active agents. These mixtures are suitable for oral administration of biologically active agents to animals.(FR) Système d'administration, en particulier acides carboxyliques, destinés à être utilisés en tant que système d'administration d'agents sensibles tels que des peptides bioactifs. Lesdits acides carboxyliques et sels d'acides carboxyliques peuvent former des mélanges non covalents avec des agents biologiquement actifs. Lesdits mélanges conviennent à l'administration orale d'agents biologiquement actifs à des animaux.