4-氨基-3,5-二甲基苯丙醇 | 454476-59-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-氨基-3,5-二甲基苯丙醇
• 英文名称: 3-(4-Amino-3,5-dimethyl-phenyl)-propan-1-ol
• 英文别名: 4-Amino-3,5-dimethylbenzenepropanol；3-(4-amino-3,5-dimethylphenyl)propan-1-ol
• CAS: 454476-59-6
• 化学式: C₁₁H₁₇NO
• 分子量: 179.262
• InChiKey: ZOLHJKXYRQTXFY-UHFFFAOYSA-N

物化性质

• 沸点：
  331.3±37.0 °C(Predicted)
• 密度：
  1.047±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于丙酮、二氯甲烷、乙酸乙酯、甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-氨基-3,5-二甲基苯丙醇 在 对甲苯磺酸 作用下， 以 二氯甲烷 为溶剂， 生成 C₃₄H₃₆Br₂N₂NiO₂
  参考文献：
  名称：

  α-二亚胺镍 (II) 催化剂在形态可控的乙烯聚合载体上的简单而牢固的配位连接

  摘要：

  摘要 本文报道了新型球形MgCl 2 负载α-二亚胺镍（II）催化剂的制备，用于淤浆相乙烯聚合。α-二亚胺配体是通过 2, 6-二取代烷基或芳基苯胺与对位具有羟基官能团的 Ace 萘醌的缩合反应合成的。羟基官能化的α-二亚胺通过配价键牢固地附着在球形MgCl 2 载体表面上。不需要连接剂将复合物连接到载体表面，并且负载镍的量是可控的，以改善聚合物粉末的形态，尤其是堆积密度。当均相催化剂负载在二氧化硅上时，催化剂活性会显着降低，但当它们负载在经过热处理的球形 MgCl 2 上时，这种降低会降低。作为均相双(N,N'-(4-(3-羟基-丙基)-2,6-二[(4-叔丁基-苯基)-苯基)氨基]乙酰萘醌二溴化镍(d)表现出最高在其他评价的均相催化剂中，其 MgCl 2 负载型催化剂（d/S-MgCl 2 ）在 MgCl 2 负载型催化剂中也表现出最高的活性。条件产生聚合物/催化剂重量比等于 6 的预

  DOI：

  10.1007/s10562-020-03116-z
• 作为产物：
  描述：

  4-溴-2,6-二甲基苯胺 在 palladium on activated charcoal 、 palladium diacetate lithium aluminium tetrahydride 、 氢气 、 三乙胺 、 三(邻甲基苯基)磷 作用下， 以 四氢呋喃 、 乙酸乙酯 、 甲苯 为溶剂， 生成 4-氨基-3,5-二甲基苯丙醇
  参考文献：
  名称：

  Efficient Slurry-Phase Homopolymerization of Ethylene to Branched Polyethylenes Using α-Diimine Nickel(II) Catalysts Covalently Linked to Silica Supports

  摘要：

  alpha-Diimine nickel(II) complexes covalently linked to a silica support were obtained by the reaction of an amino- or hydroxy-functionalized alpha-diimine nickel complex with silica particles treated with trimethyl aluminum. These silica-supported aryl R-diimine nickel(II) precatalysts linked via an amino (1a) or hydroxy functionality (1b-c) at the p-aryl position, and precatalysts linked via one (2a) or two (2b) hydroxy functionalities in the alkyl backbone were used in slurry polymerizations of ethylene to produce branched polyethylenes. Activation of precatalysts with ethylaluminum sesquichloride was effective even at very low Al/Ni ratios of 48. Initial polymerizations, performed at 60 degrees C and 150 psig ethylene, showed excellent productivities of up to 10.8 kg PE per gram of 1b (3.0 wt % nickel loading). Low productivities at temperatures above 60 degrees C can in part be overcome by increase in ethylene pressure. For example, a productivity of 6.0 kg PE per gram of 1b (3.0 wt % nickel loading) was obtained at 80 degrees C and 700 psig ethylene. The best polymerization productivities were obtained with trimethylaluminum as a traceless silica-linker, however, tetrachlorosilane and trichloroborane are attractive alternatives. Branching densities can be controlled by choice of ortho-aryl substituents. No reactor fouling occurs with these supported catalysts.

  DOI：

  10.1021/ma061032v

文献信息

• Supported olefin polymerization catalysts
  申请人：——

  公开号：US20020187892A1

  公开（公告）日：2002-12-12

  A method for forming supported late transition metal olefin polymerization catalysts is described in which an already formed transition metal complex, usually containing a reactive functional group, is placed on a support containing a complementary reactive functional group. Also described are novel polymerization catalyst components containing late transition metal complexes of neutral tridentate ligands.

  本文描述了一种制备支持的后期过渡金属烯烃聚合催化剂的方法，其中已经形成的过渡金属配合物通常包含反应性功能基团，被放置在含有互补反应性功能基团的支撑物上。此外，还描述了一种新型聚合催化剂组分，其中包含中性三齿配体的后期过渡金属配合物。
• SUPPORTED OLEFIN POLYMERIZATION CATALYSTS
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP1379562B1

  公开（公告）日：2007-08-29
• US6900153B2
  申请人：——

  公开号：US6900153B2

  公开（公告）日：2005-05-31
• Simple and Strong Dative Attachment of α-Diimine Nickel (II) Catalysts on Supports for Ethylene Polymerization with Controlled Morphology
  作者：Ehsan Kianfar、Reza Azimikia、Seyed Mohammad Faghih

  DOI：10.1007/s10562-020-03116-z

  日期：2020.8

  naphthoquinone Nickel dibromide(d) showed the highest activity among other evaluated homogeneous catalysts, its MgCl 2 supported catalyst (d/S-MgCl 2 ) has shown the highest activity among MgCl 2 supported catalysts too. These MgCl 2 supported catalysts were pre-polymerized in presence of ethylene monomer in the mild polymerization condition to yield a pre-polymerized catalyst with polymer/catalyst weight

  摘要 本文报道了新型球形MgCl 2 负载α-二亚胺镍（II）催化剂的制备，用于淤浆相乙烯聚合。α-二亚胺配体是通过 2, 6-二取代烷基或芳基苯胺与对位具有羟基官能团的 Ace 萘醌的缩合反应合成的。羟基官能化的α-二亚胺通过配价键牢固地附着在球形MgCl 2 载体表面上。不需要连接剂将复合物连接到载体表面，并且负载镍的量是可控的，以改善聚合物粉末的形态，尤其是堆积密度。当均相催化剂负载在二氧化硅上时，催化剂活性会显着降低，但当它们负载在经过热处理的球形 MgCl 2 上时，这种降低会降低。作为均相双(N,N'-(4-(3-羟基-丙基)-2,6-二[(4-叔丁基-苯基)-苯基)氨基]乙酰萘醌二溴化镍(d)表现出最高在其他评价的均相催化剂中，其 MgCl 2 负载型催化剂（d/S-MgCl 2 ）在 MgCl 2 负载型催化剂中也表现出最高的活性。条件产生聚合物/催化剂重量比等于 6 的预
• Efficient Slurry-Phase Homopolymerization of Ethylene to Branched Polyethylenes Using α-Diimine Nickel(II) Catalysts Covalently Linked to Silica Supports
  作者：Henri S. Schrekker、Vasily Kotov、Peter Preishuber-Pflugl、Peter White、Maurice Brookhart

  DOI：10.1021/ma061032v

  日期：2006.9.1

  alpha-Diimine nickel(II) complexes covalently linked to a silica support were obtained by the reaction of an amino- or hydroxy-functionalized alpha-diimine nickel complex with silica particles treated with trimethyl aluminum. These silica-supported aryl R-diimine nickel(II) precatalysts linked via an amino (1a) or hydroxy functionality (1b-c) at the p-aryl position, and precatalysts linked via one (2a) or two (2b) hydroxy functionalities in the alkyl backbone were used in slurry polymerizations of ethylene to produce branched polyethylenes. Activation of precatalysts with ethylaluminum sesquichloride was effective even at very low Al/Ni ratios of 48. Initial polymerizations, performed at 60 degrees C and 150 psig ethylene, showed excellent productivities of up to 10.8 kg PE per gram of 1b (3.0 wt % nickel loading). Low productivities at temperatures above 60 degrees C can in part be overcome by increase in ethylene pressure. For example, a productivity of 6.0 kg PE per gram of 1b (3.0 wt % nickel loading) was obtained at 80 degrees C and 700 psig ethylene. The best polymerization productivities were obtained with trimethylaluminum as a traceless silica-linker, however, tetrachlorosilane and trichloroborane are attractive alternatives. Branching densities can be controlled by choice of ortho-aryl substituents. No reactor fouling occurs with these supported catalysts.