3-Acetylamino-1-methyl-2-phenyl-indol | 1859-65-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-Acetylamino-1-methyl-2-phenyl-indol
• 英文别名: N-Methyl-2-phenyl-3-acetylaminoindol；N-(1-methyl-2-phenyl-indol-3-yl)-acetamide；N-(1-methyl-2-phenylindol-3-yl)acetamide
• CAS: 1859-65-0
• 化学式: C₁₇H₁₆N₂O
• 分子量: 264.327
• InChiKey: YFSINRIUHXAUSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  34
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-Acetylamino-1-methyl-2-phenyl-indol 在 四磷十氧化物 作用下， 以 甲苯 为溶剂， 以48%的产率得到5,11-Dimethylindolo[3,2-c]isoquinoline
  参考文献：
  名称：

  A versatile synthetic route to 11H-indolo[3,2-c]isoquinolines

  摘要：

  A wide variety of indoloisoquinoline derivatives are prepared from the acid-catalyzed cyclization of 3-amido-2-phenylindoles, which in turn were obtained from the Beckmann rearrangement of 2-phenylindole-3-oximes. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.07.107
• 作为产物：
  描述：

  在 硫酸 作用下， 以 乙腈 为溶剂， 以60%的产率得到3-Acetylamino-1-methyl-2-phenyl-indol
  参考文献：
  名称：

  A versatile synthetic route to 11H-indolo[3,2-c]isoquinolines

  摘要：

  A wide variety of indoloisoquinoline derivatives are prepared from the acid-catalyzed cyclization of 3-amido-2-phenylindoles, which in turn were obtained from the Beckmann rearrangement of 2-phenylindole-3-oximes. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.07.107

文献信息

• An efficient base-mediated intramolecular condensation of 2-(disubstituted amino)-benzonitriles to 3-aminoindoles
  作者：Churl Min Seong、Chul Min Park、Jinil Choi、No Sang Park

  DOI：10.1016/j.tetlet.2008.12.052

  日期：2009.3

  A concise and versatile method for the preparation of 3-aminoindoles from 2-(disubstituted amino)-benzonitriles is described, and in situ functionalizations were illustrated. (C) 2008 Elsevier Ltd. All rights reserved.
• A versatile synthetic route to 11H-indolo[3,2-c]isoquinolines
  作者：Ji Qu、Naresh Kumar、Mahiuddin Alamgir、David StC. Black

  DOI：10.1016/j.tetlet.2009.07.107

  日期：2009.10

  A wide variety of indoloisoquinoline derivatives are prepared from the acid-catalyzed cyclization of 3-amido-2-phenylindoles, which in turn were obtained from the Beckmann rearrangement of 2-phenylindole-3-oximes. (C) 2009 Elsevier Ltd. All rights reserved.