4-amino-5-methyl-2-(trifluoromethyl)pyridine | 340809-48-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-amino-5-methyl-2-(trifluoromethyl)pyridine
• 英文别名: 5-Methyl-2-(trifluoromethyl)pyridin-4-amine
• CAS: 340809-48-5
• 化学式: C₇H₇F₃N₂
• 分子量: 176.141
• InChiKey: BMHDTBXWBPSDPI-UHFFFAOYSA-N

物化性质

• 沸点：
  248.6±40.0 °C(Predicted)
• 密度：
  1.307±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 危险性防范说明：
  P261,P264,P271,P280,P302+P352,P304+P340,P305+P351+P338,P312,P362,P403+P233,P501
• 危险性描述：
  H315,H319,H335

反应信息

• 作为反应物：
  描述：

  4-amino-5-methyl-2-(trifluoromethyl)pyridine 在 硫酸 、 sodium nitrite 、 溶剂黄146 作用下， 以 水 为溶剂， 反应 1.67h， 以64%的产率得到6-(trifluoromethyl)-2H-pyrazolo[4,3-c]pyridine
  参考文献：
  名称：

  Synthesis of 5-alkyl-4-amino-2-(trifluoromethyl)pyridines and their transformation into trifluoromethylated 1 H -pyrazolo[4,3- c ]pyridines

  摘要：

  5-Alkyl-4-amino-2-(trifluoromethyl)pyridines were prepared in good yields starting from the corresponding pyridinols either using condensation with tosyl isocyanate or by alkylation with 2-chloroacetamide and subsequent Smiles type rearrangement. The cyclisation of diazonium salts, generated from 5-alkyl-4-amino-2-(trifluoromethyl)pyridines afforded trifluoromethylated 1H-pyrazolo[4,3-c] pyri dines. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00024-2
• 作为产物：
  描述：

  5-methyl-2-trifluoromethyl-4H-pyran-4-one 在 ammonium hydroxide 、 potassium carbonate 、 sodium iodide 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 反应 56.0h， 生成 4-amino-5-methyl-2-(trifluoromethyl)pyridine
  参考文献：
  名称：

  Synthesis of 5-alkyl-4-amino-2-(trifluoromethyl)pyridines and their transformation into trifluoromethylated 1 H -pyrazolo[4,3- c ]pyridines

  摘要：

  5-Alkyl-4-amino-2-(trifluoromethyl)pyridines were prepared in good yields starting from the corresponding pyridinols either using condensation with tosyl isocyanate or by alkylation with 2-chloroacetamide and subsequent Smiles type rearrangement. The cyclisation of diazonium salts, generated from 5-alkyl-4-amino-2-(trifluoromethyl)pyridines afforded trifluoromethylated 1H-pyrazolo[4,3-c] pyri dines. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00024-2

文献信息

• [EN] CYCLOPROPYL-(HETERO)ARYL-SUBSTITUTED ETHYLSULPHONYLPYRIDINE DERIVATIVES<br/>[FR] DÉRIVÉS D'ÉTHYLSULFONYLPYRIDINE À SUBSTITUTION CYCLOPROPYLE- (HÉTÉRO)ARYLE
  申请人：[en]BOEHRINGER INGELHEIM VETMEDICA GMBH

  公开号：WO2023036934A1

  公开（公告）日：2023-03-16

  The present invention relates to cyclopropyl-(hetero)aryl substituted ethylsulphonyl-pyridine derivatives of formula (I),wherein the variables are as defined in the description and in the claims, which can be used as antiparasitic agents for the treatment, prevention and/or control of parasitic infections and/or infestations in animals.
• Synthesis of 5-alkyl-4-amino-2-(trifluoromethyl)pyridines and their transformation into trifluoromethylated 1 H -pyrazolo[4,3- c ]pyridines
  作者：Vladimir I Tyvorskii、Denis N Bobrov、Oleg G Kulinkovich、Kourosch Abbaspour Tehrani、Norbert De Kimpe

  DOI：10.1016/s0040-4020(01)00024-2

  日期：2001.3

  5-Alkyl-4-amino-2-(trifluoromethyl)pyridines were prepared in good yields starting from the corresponding pyridinols either using condensation with tosyl isocyanate or by alkylation with 2-chloroacetamide and subsequent Smiles type rearrangement. The cyclisation of diazonium salts, generated from 5-alkyl-4-amino-2-(trifluoromethyl)pyridines afforded trifluoromethylated 1H-pyrazolo[4,3-c] pyri dines. (C) 2001 Elsevier Science Ltd. All rights reserved.