| 929720-08-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 929720-08-1
• 化学式: C₃₅H₃₉N₃O₈
• 分子量: 629.71
• InChiKey: UBBJOPWUVQQKLB-GDLZYMKVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.64
• 重原子数：
  46.0
• 可旋转键数：
  8.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  122.76
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  在 甲胺 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 3.0h， 以72%的产率得到1-benzyl 2-(tert-butyl) (R)-1-(1-methoxy-1-oxo-3-phenylpropan-2-yl)hydrazine-1,2-dicarboxylate
  参考文献：
  名称：

  Synthesis of Nα-Z, Nβ-Fmoc or Boc protected α-hydrazinoacids and study of the coupling reaction in solution of Nα-Z-α-hydrazinoesters

  摘要：

  The preparation of chiral orthogonally protected N-alpha-Z, N-beta-Fmoc- or Boc-alpha-hydrazinoacids derivatives, directly suitable for SPPS, is described in six steps with good yields starting from the corresponding alpha-aminoacids. The coupling reaction assays performed in liquid phase between N-alpha-Z-hydrazinoesters and N-Fmoc-alpha-aminoacids demonstrated the low reactivity of the hydrazinoester derivatives. However, we found that the acid fluoride method allowed the formation of hydrazinodipeptides almost quantitatively. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.12.085
• 作为产物：
  描述：

  L-苯基乳酸甲酯 在 4-二甲氨基吡啶 、 dialkylazodicarboxylate 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 反应 11.5h， 生成
  参考文献：
  名称：

  Synthesis of Nα-Z, Nβ-Fmoc or Boc protected α-hydrazinoacids and study of the coupling reaction in solution of Nα-Z-α-hydrazinoesters

  摘要：

  The preparation of chiral orthogonally protected N-alpha-Z, N-beta-Fmoc- or Boc-alpha-hydrazinoacids derivatives, directly suitable for SPPS, is described in six steps with good yields starting from the corresponding alpha-aminoacids. The coupling reaction assays performed in liquid phase between N-alpha-Z-hydrazinoesters and N-Fmoc-alpha-aminoacids demonstrated the low reactivity of the hydrazinoester derivatives. However, we found that the acid fluoride method allowed the formation of hydrazinodipeptides almost quantitatively. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.12.085