1,3-dimethyl-5-methoxycarbonylindolin-2-one | 503306-60-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1,3-dimethyl-5-methoxycarbonylindolin-2-one
• 英文别名: methyl 1,3-dimethyl-2-oxo-3H-indole-5-carboxylate
• CAS: 503306-60-3
• 化学式: C₁₂H₁₃NO₃
• 分子量: 219.24
• InChiKey: JHRXMQOVBYRPSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,3-dimethyl-5-methoxycarbonylindolin-2-one 在 ammonium cerium(IV) nitrate 作用下， 以 乙腈 为溶剂， 以84%的产率得到1,3-dimethyl-5-methoxycarbonyl-3-nitrooxyindolin-2-one
  参考文献：
  名称：

  Reaction of indolin-2-ones with cerium(IV) ammonium nitrate

  摘要：

  The reaction of indolin-2-ones with CAN is studied. When the reaction is carried out in an alcohol as solvent, 3-alkoxyindolin-2ones are obtained in very good yields. If a non-nucleophilic solvent is used (THF, acetonitrile) 3-nitroxy derivatives are isolated. If the aromatic ring bears an electron-donating group, reactions are accompanied by aromatic ring nitration. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)01284-x
• 作为产物：
  描述：

  4-(Acryloyl-methyl-amino)-3-iodo-benzoic acid methyl ester 在 偶氮二异丁腈 、 三正丁基氢锡 作用下， 以 甲苯 为溶剂， 反应 1.0h， 以82%的产率得到1,3-dimethyl-5-methoxycarbonylindolin-2-one
  参考文献：
  名称：

  Reaction of indolin-2-ones with cerium(IV) ammonium nitrate

  摘要：

  The reaction of indolin-2-ones with CAN is studied. When the reaction is carried out in an alcohol as solvent, 3-alkoxyindolin-2ones are obtained in very good yields. If a non-nucleophilic solvent is used (THF, acetonitrile) 3-nitroxy derivatives are isolated. If the aromatic ring bears an electron-donating group, reactions are accompanied by aromatic ring nitration. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)01284-x

文献信息

• Reaction of indolin-2-ones with cerium(IV) ammonium nitrate
  作者：Carmen Escolano、Lluı́s Vallverdú、Keith Jones

  DOI：10.1016/s0040-4020(02)01284-x

  日期：2002.11

  The reaction of indolin-2-ones with CAN is studied. When the reaction is carried out in an alcohol as solvent, 3-alkoxyindolin-2ones are obtained in very good yields. If a non-nucleophilic solvent is used (THF, acetonitrile) 3-nitroxy derivatives are isolated. If the aromatic ring bears an electron-donating group, reactions are accompanied by aromatic ring nitration. (C) 2002 Elsevier Science Ltd. All rights reserved.