1-(6,7-diphenyl-5H-[1,3]dioxolo[4,5-f]indol-5-yl)ethanone | 1332835-67-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-(6,7-diphenyl-5H-[1,3]dioxolo[4,5-f]indol-5-yl)ethanone
• 英文别名: 1-(6,7-Diphenyl-[1,3]dioxolo[4,5-f]indol-5-yl)ethanone；1-(6,7-diphenyl-[1,3]dioxolo[4,5-f]indol-5-yl)ethanone
• CAS: 1332835-67-2
• 化学式: C₂₃H₁₇NO₃
• 分子量: 355.393
• InChiKey: GSJOCQXFQBNEPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  40.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3,4-亚甲二氧基苯胺 在 palladium diacetate 、 copper(II) bis(trifluoromethanesulfonate) 、 silver(l) oxide 作用下， 以 二氯甲烷 、 N,N-二甲基乙酰胺 为溶剂， 反应 8.0h， 生成 1-(6,7-diphenyl-5H-[1,3]dioxolo[4,5-f]indol-5-yl)ethanone
  参考文献：
  名称：

  Synthesis of indoles via palladium-catalyzed C–H activation of N-aryl amides followed by coupling with alkynes

  摘要：

  A convenient and efficient method for the construction of indole skeleton was developed via Pd-catalyzed C-H activation of N-aryl amides and subsequent coupling with alkynes. Both stoichiometric and catalytic versions have been successfully achieved. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.07.009

文献信息

• Mild and efficient synthesis of indoles and isoquinolones<i>via</i>a nickel-catalyzed Larock-type heteroannulation reaction
  作者：Wei-Zhi Weng、Jian Xie、Bo Zhang

  DOI：10.1039/c8ob00795k

  日期：——

  A simple and efficient approach for the preparation of substituted indoles and isoquinolones via a nickel-catalyzed Larock-type heteroannulation reaction is reported. This transformation employed air-stable and inexpensive Ni(dppp)Cl2 as a precatalyst and Et3N as a mild base. Moreover, the reaction occurs efficiently under mild conditions, and a wide range of substituted indoles and isoquinolones bearing

  报道了一种通过镍催化的Larock型杂环化反应制备取代的吲哚和异喹诺酮的简单有效的方法。该转化采用空气稳定且廉价的Ni（dppp）Cl 2作为前催化剂，Et 3 N作为温和碱。此外，该反应在温和的条件下有效地进行，并且以中等至优异的产率获得了带有各种官能团的多种取代的吲哚和异喹诺酮。
• Synthesis of indoles via palladium-catalyzed C–H activation of N-aryl amides followed by coupling with alkynes
  作者：Feng Zhou、Xiuling Han、Xiyan Lu

  DOI：10.1016/j.tetlet.2011.07.009

  日期：2011.9

  A convenient and efficient method for the construction of indole skeleton was developed via Pd-catalyzed C-H activation of N-aryl amides and subsequent coupling with alkynes. Both stoichiometric and catalytic versions have been successfully achieved. (C) 2011 Elsevier Ltd. All rights reserved.