N-hydroxy-2-(p-tolylamino)acetamide | 14108-48-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-hydroxy-2-(p-tolylamino)acetamide
• 英文别名: 2-(4-methylphenyl-1-ylamino)acethydroxamic acid；<4-Methyl-phenylamino>-acethydroxamsaeure；p-Methyl-anilino-acethydroxamsaeure；N-p-tolyl-glycine hydroxyamide；N-hydroxy-2-(4-methylanilino)acetamide
• CAS: 14108-48-6
• 化学式: C₉H₁₂N₂O₂
• 分子量: 180.206
• InChiKey: USAJLDRNEOVHJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  61.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 N-hydroxy-2-(p-tolylamino)acetamide 、 二乙胺 生成 N-Diethylaminomethyl-N-hydroxy-2-p-tolylamino-acetamide
  参考文献：
  名称：

  芳氧基乙酸和（芳氨基）乙酰羟肟酸的氨基甲基化和还原

  摘要：

  一些芳氧基乙酸和（芳氨基）乙酰异羟肟酸与甲醛和秒缩合的表示和性质。描述了可从胺获得的氨基甲基化合物。还报道了用雷尼镍和氢以及用 LiAlH4 还原异羟肟酸。

  DOI：

  10.1002/ardp.19703031112
• 作为产物：
  描述：

  [(4-甲基苯基)氨基]乙酸乙酯 在 盐酸羟胺 、 sodium methylate 作用下， 以 甲醇 为溶剂， 以50%的产率得到N-hydroxy-2-(p-tolylamino)acetamide
  参考文献：
  名称：

  含芳基异羟肟酸的尿素酶抑制剂，可有效治疗幽门螺杆菌感染

  摘要：

  设计，合成和评估了一系列新型的含苯胺的异羟肟酸，作为抗毒剂，用于治疗幽门螺杆菌引起的胃炎和胃溃疡。基于体外酶的筛选以及体内测定和结构活性关系（SAR）研究导致发现了三种有效的脲酶抑制剂3-（3,5-二氯苯基氨基）N-羟基丙酰胺（3a），3-（2-氯苯基氨基）N-羟基丙酰胺（3d）和3-（2,4-二氯苯基氨基）N-羟基丙酰胺（3n）。化合物3a，3d和3n表现出优异的脲酶抑制作用，IC 50值为0.043±0.005、0.055±0.008和0.018±0.002μM，并且在32 mg / kg bid剂量下显着抑制了胃炎的发展，根除幽门螺杆菌的比率达到92.3、84.6和100％，分别。初步安全性研究（对小鼠的急性毒性）显示，LD 50分别为2982.8、3349.4和3126.9 mg / kg的KM小鼠对3a，3d和3n的耐受性良好。总体而言，本研究中获得的数据表明3a，3d和3n，尤

  DOI：

  10.1016/j.ejmech.2018.06.065

文献信息

• Oxidative hair dye compositions
  申请人：Bristol-Myers Squibb Company

  公开号：EP0891765A2

  公开（公告）日：1999-01-20

  The invention provides compositions and methods for the oxidative coloring of human hair. The compositions of the invention contain as a primary dye intermediate a 1-(4-aminophenyl) pyrrolidine, or a cosmetically acceptable salt thereof. The compositions may also contain at least one other primary intermediate and conventional coupling compounds, in addition to an oxidizing agent and other components typically used in oxidative hair dye preparations. Preferred dye intermediates in the compositions of the invention include 1-(4-aminophenyl) pyrrolidine and 1-(4-amino-3-methylphenyl) pyrrolidine, or cosmetically acceptable salts thereof, which produce intense neutral colors when used in admixture with a suitable coupling agents, such as 3-aminophenol, in conventional hair dye base formulations.

  本发明提供了对人类头发进行氧化染色的组合物和方法。本发明的组合物含有 1-（4-氨基苯基）吡咯烷或其美容上可接受的盐作为初级染料中间体。除了氧化剂和氧化染发制剂中通常使用的其他成分外，组合物中还可能含有至少一种其他主中间体和常规偶联化合物。本发明组合物中优选的染料中间体包括 1-（4-氨基苯基）吡咯烷和 1-（4-氨基-3-甲基苯基）吡咯烷，或它们在化妆品上可接受的盐，当它们与合适的偶联剂（如 3-氨基苯酚）混合用于常规染发剂基料配方中时，可产生强烈的中性色。
• Novel Bis-(2,4-diaminophenoxy) benzenes and their use as coupling components in oxidative hair coloring compositions and methods
  申请人：Bristol-Myers Squibb Company

  公开号：EP0918051A1

  公开（公告）日：1999-05-26

  The invention provides compositions and methods containing novel bis-(2,4-diaminophenoxy) benzene coupling compounds, and cosmetically acceptable salts thereof, for use with conventional primary intermediate dye compounds and oxidizing agents for the oxidative coloring of human hair. The compositions of the invention may also contain other components typically used in oxidative hair dye preparations to impart intense and lasting coloration to hair.

  本发明提供了含有新型双-（2,4-二氨基苯氧基）苯偶联化合物及其美容上可接受的盐的组合物和方法，可与传统的初级中间染料化合物和氧化剂一起用于人类头发的氧化着色。本发明的组合物还可含有氧化染发制剂中通常使用的其他成分，以赋予头发浓烈持久的着色效果。
• Method of assessing hair colour changes
  申请人：Conopco, Inc.

  公开号：US10444157B2

  公开（公告）日：2019-10-15

  The invention provides a method of assessing the potential color protecting effect in vivo of a test formulation such as rinse-off hair treatment formulation, the method comprising the steps of: providing a sample of the test formulation to be assessed; providing a model substrate in the form of a hair switch which has been artificially colored; applying the test formulation to the hair switch; subsequently rinsing the test formulation from the hair switch; collecting the rinse liquor and analysing it for the presence of eluted color; characterized in that the artificial color used to color the hair switch is a permanent hair colorant with a shade level 1 or 2 according to the International Color Chart (I.C.C.). The method provides improved sensitivity and differentiation, and enables the tester to compare different technologies in terms of effectiveness.

  本发明提供了一种评估测试配方（如冲洗式头发护理配方）体内潜在护色效果的方法，该方法包括以下步骤提供待评估的试验配方样品；提供人工着色的毛发开关形式的模型基底；将试验配方涂抹在毛发开关上；随后将试验配方从毛发开关上冲洗下来；收集冲洗液并分析其中是否存在洗脱的颜色；其特征在于，用于给毛发开关着色的人工色素是一种永久性染发剂，根据国际色表（I. C. C.C.C.）。该方法提高了灵敏度和区分度，使测试人员能够比较不同技术的有效性。
• Oxidative coloration of hair with reduced hair damage
  申请人：Conopco, Inc.

  公开号：US10588837B2

  公开（公告）日：2020-03-17

  The invention provides a packaged composition for the oxidative coloration of hair which is formulated in two parts, the composition comprising: (i) an aqueous hair colorant part comprising one or more oxidative dye precursors, and less than 1% oleic acid by weight based on total weight of part (i); (ii) an aqueous colour developer part comprising one or more oxidising agents, at least 5% stearic acid by weight based on total weight of part (ii); and less than 1% oleic acid by weight based on total weight of part (ii); in which parts (i) and (ii) are adapted to be mixed together before application to the hair. The compositions provide an improved level of hair damage protection during the colouring process without compromising on colour delivery.

  本发明提供了一种用于头发氧化着色的包装组合物，该组合物分两部分配制，组合物包括(i)水性染发剂部分，包括一种或多种氧化染料前体，以及按(i)部分总重量计算重量比小于 1%的油酸；(ii)水性显色剂部分，包括一种或多种氧化剂，按(ii)部分总重量计算重量比至少 5%的硬脂酸；以及按(ii)部分总重量计算重量比小于 1%的油酸；其中(i)和(ii)部分适于在用于头发之前混合在一起。在染发过程中，这些组合物能提供更好的头发损伤保护，同时不影响颜色的传递。
• Two-part hair dye compositions containing polyether polyurethanes and conditiong agents
  申请人：——

  公开号：US20030140430A1

  公开（公告）日：2003-07-31

  The present invention describes a two-part oxidative hair dye composition which comprises in one or both component parts at least one polyether polyurethane in combination with at least one cationic conditioning agent. The two component parts of the composition comprise a dye component composition, which includes primary intermediates and couplers, and a developing component composition, which includes an oxidizing agent, such as hydrogen peroxide. It has surprisingly been found by the present inventors that nonionic polyether polyurethane polymers and cationic conditioning agents contained in the oxidative hair dye compositions of the present invention impart and significantly enhance additional conditioning and rheological benefits to the hair. Other components commonly used in oxidative hair dye products can be added to one or both component parts of the compositions of the present invention. After mixing the two component compositions, the resulting hair dye composition mixture is thick, conveniently applied, and provides superior rheological and conditioning properties to the hair.

  本发明描述了一种双组分氧化染发组合物，它在一个或两个组分中包含至少一种聚醚聚氨酯和至少一种阳离子调节剂。组合物的两个组成部分包括染料成分组合物（其中包括初级中间体和偶联剂）和显影成分组合物（其中包括氧化剂，如过氧化氢）。本发明者惊喜地发现，本发明的氧化型染发剂组合物中所含的非离子聚醚聚氨酯聚合物和阳离子调理剂可赋予并显著增强头发额外的调理和流变效果。氧化性染发产品中常用的其他成分可以添加到本发明组合物的一个或两个组分中。将两种成分的组合物混合后，得到的染发剂组合物混合物粘稠，使用方便，可为头发提供优异的流变和调理特性。