4-chloro-2-vinylbenzoic acid | 1035699-99-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-chloro-2-vinylbenzoic acid
• 英文别名: 4-chloro-2-ethenylbenzoic acid
• CAS: 1035699-99-0
• 化学式: C₉H₇ClO₂
• 分子量: 182.606
• InChiKey: QNRZGHOFZBNESN-UHFFFAOYSA-N

物化性质

• 沸点：
  322.9±35.0 °C(Predicted)
• 密度：
  1.305±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-chloro-2-vinylbenzoic acid 、 苯胺 在 草酰氯 、 4-碘甲苯 、 三氟化硼乙醚 、 N,N-二甲基甲酰胺 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 4.5h， 生成 (Z)-5-chloro-3-methylene-N-phenylisobenzofuran-1(3H)-imine
  参考文献：
  名称：

  Study on the ArI-catalyzed intramolecular oxy-cyclization of 2-alkenylbenzamides to benzoiminolactones

  摘要：

  通过ArI/mCPBA催化剂/氧化剂系统介导的2-烯基苯甲酰胺的氧环化，开发了一种无金属合成苯并咪醇内酯的方法。

  DOI：

  10.1039/d0ob00612b
• 作为产物：
  描述：

  2-氨基-4-氯苯甲酸 在 trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II) 亚硝酸特丁酯 、 三氟化硼乙醚 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 1.17h， 生成 4-chloro-2-vinylbenzoic acid
  参考文献：
  名称：

  Compounds and methods of use

  摘要：

  所选化合物对于预防和治疗疾病，如VEGF介导的疾病，具有有效性。该发明涵盖了新颖的化合物、类似物、前药和其药用可接受的盐，以及用于预防和治疗涉及癌症等疾病和其他疾病或病况的药物组合物和方法。该发明还涉及用于制备此类化合物的过程，以及用于此类过程的有用中间体。

  公开号：

  US20080161346A1

文献信息

• Production of vinyl halide-polyolefin polymer
  申请人：OCCIDENTAL CHEMICAL CORPORATION

  公开号：EP0049595A1

  公开（公告）日：1982-04-14

  Production of vinyl halide-polyolefin graft copolymers by a liquid phase bulk polymerization process is carried out in the presence of a diluent. Suitable diluents preferably have vaporization pressure characteristics, within 6.89 x 102 kPa, and similar liquid state viscosity, as-vinyl-halide monomer. The diluents are soluble in vinyl halide monomer under the reaction conditions and are inert to the polymerization mass. The diluents are straight or branched chain or cyclic saturated hydrocarbons having from 3 to 15 carbon atoms. Particularly useful diluents are n-propane, n-butane, isobutane or mixtures thereof. The diluents are utilized in amounts from 0.2 to less than 50.0 percent based upon the total weight of the reaction charge. The polymers thus produced can be used to make moulded articles.

  卤化乙烯基-聚烯烃接枝共聚物的液相团聚工艺是在稀释剂存在下进行的。合适的稀释剂最好具有 6.89 x 102 千帕以内的汽化压力特性，以及与卤化乙烯基单体相似的液态粘度。在反应条件下，稀释剂可溶于卤化乙烯单体，并对聚合物质具有惰性。稀释剂是具有 3 至 15 个碳原子的直链或支链或环状饱和碳氢化合物。特别有用的稀释剂是正丙烷、正丁烷、异丁烷或它们的混合物。稀释剂的用量为反应物总重量的 0.2%到 50.0%以下。由此生产出的聚合物可用于制造模制件。
• Blends of polyolefin graft polymers and ASA polymers, SMA polymers and condensation polymers
  申请人：OCCIDENTAL CHEMICAL CORPORATION

  公开号：EP0137518A2

  公开（公告）日：1985-04-17

  A novel thermoplastic polymer composition comprises a blend of (A) a polyolefin graft polymer and (B) a copolymer of acrylonitrile and styrene modified with a base polymer such as an acrylic polymer, a chlorinated polyethylene, or a terpolymer of styrene, acrylonitrile and a polyene modifier, or (C) a copolymer of styrene and maleic anhydride and modifications thereof, or (D) a condensation polymer such as a polycarbonate, a polyester of bisphenol and phthalic acids, or a polyalkylene terephthalate.

  一种新型热塑性聚合物组合物包括以下物质的混合物：(A)聚烯烃接枝聚合物；(B)丙烯腈和苯乙烯的共聚物，该共聚物用丙烯酸聚合物、氯化聚乙烯或苯乙烯的三元共聚物等基础聚合物改性，或(C)苯乙烯和马来酸酐的共聚物及其改性物；或(D)聚碳酸酯等缩聚聚合物、(C) 苯乙烯和马来酸酐的共聚物及其改性物，或 (D) 缩合聚合物，如聚碳酸酯、双酚和邻苯二甲酸的聚酯或聚对苯二甲酸乙二醇酯。
• Graft polymers of polymerizable monomers and olefin polymers
  申请人：OCCIDENTAL CHEMICAL CORPORATION

  公开号：EP0137519A2

  公开（公告）日：1985-04-17

  Graft polymers are prepared by reacting an ethylenically unsaturated polymerizable monomer with a polymer of an olefin of 2 to about 8 carbon atoms in a process wherein the olefin polymer is substantially insoluble in the monomer but is capable of absorbing the monomer. In a preferred aspect, a vinyl halide polyolefin graft polymer is produced by reacting a solid polyolefin particle with a vinyl halide monomer in which the polyolefin is substantially insoluble, but is capable of absorbing the monomer. The solid particles can be contacted with the monomer in one step or in stages. When the stage-wise reaction is continued until the proportion of polyolefin in the polymer product is about 2 to about 20 weight percent, the resulting product can be formed to a transparent or translucent article. When a small proportion of solid polyolefin is employed in the polymerization process, both a graft polymer and a polymer of the unsaturated monomer are simultaneously produced in the same reactor and can be readily mechanically separated into the individual products.

  接枝聚合物是通过乙烯基不饱和可聚合单体与 2 至 8 个碳原子的烯烃聚合物反应制备的，反应过程中烯烃聚合物基本上不溶于单体，但能吸收单体。在一个优选方面，卤化乙烯基聚烯烃接枝聚合物是通过固体聚烯烃颗粒与卤化乙烯基单体反应制得的，其中聚烯烃基本上不溶于卤化乙烯基单体，但能吸收单体。固体颗粒可以一步或分阶段与单体接触。当分阶段反应持续进行，直到聚合物产品中聚烯烃的比例达到约 2% 至约 20% 的重量百分比时，所得产品可形成透明或半透明制品。当在聚合过程中使用小比例的固体聚烯烃时，接枝聚合物和不饱和单体聚合物可在同一反应器中同时生产，并能很容易地机械分离成单个产品。
• Solvent based coating composition
  申请人：Nippon Paint Co., Ltd.

  公开号：EP0413352A2

  公开（公告）日：1991-02-20

  Disclosed is a solvent based coating composition comprising at least one kind of vinyl polymer and an organic solvent, wherein any one of said vinyl polymer has at least one kind selected from the group consisting of an active hydrogen-containing group and a substituted acylamide group, and said vinyl polymer contains the above described two kinds of group as a whole.

  本发明公开了一种溶剂型涂料组合物，该组合物包含至少一种乙烯基聚合物和一种有机溶剂，其中任一种所述乙烯基聚合物具有至少一种从活性含氢基团和取代的酰酰胺基团组成的组中选出的基团，且所述乙烯基聚合物整体包含上述两种基团。
• Aqueous dispersion coating composition
  申请人：Nippon Paint Co., Ltd.

  公开号：EP0413351A2

  公开（公告）日：1991-02-20

  Disclosed is an aqueous dispersion coating composition comprising at least one kind of resins, wherein any one of said resins has at least one kind selected from the group consisting of an active hydrogen-containing group, a substituted acylamide group and a water dispersible or water-soluble group, and said resin composition contains the above described kinds of group as a whole.

  本发明公开了一种水性分散涂料组合物，该组合物包含至少一种树脂，其中任一种树脂具有至少一种选自活性含氢基团、取代的酰酰胺基团和水分散或水溶性基团组成的组的基团，且所述树脂组合物整体包含上述基团。