2-[(3,5-dimethyl-4-methoxypyridin-2-yl)methyl]sulfinyl-6-[(2-furanyl)carboxamido]-5-dipropylamino-1H-benzimidazole | 1319671-61-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-[(3,5-dimethyl-4-methoxypyridin-2-yl)methyl]sulfinyl-6-[(2-furanyl)carboxamido]-5-dipropylamino-1H-benzimidazole
• 英文别名: N-[6-(dipropylamino)-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-3H-benzimidazol-5-yl]furan-2-carboxamide
• CAS: 1319671-61-8
• 化学式: C₂₇H₃₃N₅O₄S
• 分子量: 523.656
• InChiKey: MWBJZIYFEFYAFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  37
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  133
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  N-(5-(dipropylamino)-2-mercapto-1H-benzo[d]imidazol-6-yl)furan-2-carboxamide 在 potassium carbonate 、 potassium hydrogencarbonate 、 间氯过氧苯甲酸 、 potassium iodide 作用下， 以 乙醇 、 二氯甲烷 、 丙酮 为溶剂， 反应 4.25h， 生成 2-[(3,5-dimethyl-4-methoxypyridin-2-yl)methyl]sulfinyl-6-[(2-furanyl)carboxamido]-5-dipropylamino-1H-benzimidazole
  参考文献：
  名称：

  A reverse method for diversity introduction of benzimidazole to synthesize H+/K+-ATP enzyme inhibitors

  摘要：

  A series of 2-[(2-pyridylmethyl)sulfinyl]benzimidazole derivatives were synthesized via a solution phase synthetic route using a reversal method of diversity introduction. Using this synthetic strategy, we obtained two key intermediates (4-A and 4-B) simultaneously, which allows us to introduce diversity points onto the benzimidazole part of the final product under reliable reaction conditions to identify potent H+/K+-ATP enzyme inhibitors. Compound 141 (IC50 = 1.6 x 10 (5) M) was comparable with H+/K+-ATP enzyme inhibitor in vitro. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.05.080