[(2R,3R,4S,5R,6S)-3,4,5-triacetyloxy-6-[4-[[3-(azidomethyl)-5-[[1-[(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]triazol-4-yl]methoxy]phenoxy]methyl]triazol-1-yl]oxan-2-yl]methyl acetate | 1333231-60-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [(2R,3R,4S,5R,6S)-3,4,5-triacetyloxy-6-[4-[[3-(azidomethyl)-5-[[1-[(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]triazol-4-yl]methoxy]phenoxy]methyl]triazol-1-yl]oxan-2-yl]methyl acetate
• CAS: 1333231-60-9
• 化学式: C₄₁H₄₉N₉O₂₀
• 分子量: 987.888
• InChiKey: KTCCTSTUPOFJPC-YYUHPVKYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  70
• 可旋转键数：
  28
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  323
• 氢给体数：
  0
• 氢受体数：
  26

反应信息

• 作为反应物：
  描述：

  [(2R,3R,4S,5R,6S)-3,4,5-triacetyloxy-6-[4-[[3-(azidomethyl)-5-[[1-[(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]triazol-4-yl]methoxy]phenoxy]methyl]triazol-1-yl]oxan-2-yl]methyl acetate 、 2,6-bis(4-propargyloxyphenylmethylene)cyclohexanone 在 copper(II) sulfate 、 sodium ascorbate 作用下， 以89%的产率得到
  参考文献：
  名称：

  Synthesis and cardio protective biological applications of glucodendrimers by H9C2 cell studies

  摘要：

  Novel glucodendrimers scaffolds containing alpha-D-glucopyranoside at the surface and triazole as bridging unit have been synthesized. Cardiomyocytes were exposed to normal and high glucose level in the presence and absence of glucodendrimers. Cytotoxicity studies were also carried out and the expression of metalloproteinases mainly MMP-2 and 9 was confirmed with gelatine zymography and RT-PCR gene expression studies. Cardio protective efficiency of the synthesized glucodendrimers against high glucose induced toxicity on mettalloproteinase-2 and 9 and also on H9C2 cell lines revealed that higher generation glucodendrimers 6 and 8 are more effective than the lower generation glucodendrimers. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carbpol.2013.08.040
• 作为产物：
  描述：

  [(2R,3R,4S,5R,6S)-3,4,5-triacetyloxy-6-[4-[[3-(chloromethyl)-5-[[1-[(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]triazol-4-yl]methoxy]phenoxy]methyl]triazol-1-yl]oxan-2-yl]methyl acetate 在 sodium azide 作用下， 以 水 、 丙酮 为溶剂， 反应 3.0h， 以98%的产率得到[(2R,3R,4S,5R,6S)-3,4,5-triacetyloxy-6-[4-[[3-(azidomethyl)-5-[[1-[(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]triazol-4-yl]methoxy]phenoxy]methyl]triazol-1-yl]oxan-2-yl]methyl acetate
  参考文献：
  名称：

  新型BODIPY糖缀合树状聚合物的合成，表征，光学和电化学性质以及抗菌活性†

  摘要：

  三唑支化的BODIPY糖缀合的树状大分子通过点击化学通过收敛方法以高收率合成。当增加树枝状大分子的生成时，所有糖类树枝状大分子显示出荧光强度的增加。树枝状聚合物的循环伏安图1，2和3示出了准可逆的行为。所有的硼二吡咯并亚甲基（BODIPY）树状聚合物均显示出对革兰氏阳性和革兰氏阴性细菌的抗菌活性。，金黄色葡萄球菌和枯草芽孢杆菌，鼠伤寒沙门氏菌和大肠杆菌以及树状大分子3 与所有其他合成的树状聚合物相比，它具有更好的抗菌活性。

  DOI：

  10.1039/c7nj04412g

文献信息

• Synthesis and In-vitro anti-inflammatory activity of novel glycodendrimers with benzene 1,3,5 carboxamide core and triazole as branching unit
  作者：Perumal Rajakumar、Ramasamy Anandhan

  DOI：10.1016/j.ejmech.2011.06.017

  日期：2011.9

  Novel glycodendrimers scaffolds containing twelve and eighteen a-D-glycopyranoside at the periphery and triazole as branching unit have been synthesized using click chemistry. Higher generation dendrimers exhibit better anti-inflammatory activity than the lower generation due to the presence of more triazole branching units and multivalent glycopyranoside units. (C) 2011 Elsevier Masson SAS. All rights reserved.