1-allyl-4,6-dimethoxy-2,3-diphenyl-7-(1-nitropent-4-en-2-yl)-1H-indole | 1220960-55-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-allyl-4,6-dimethoxy-2,3-diphenyl-7-(1-nitropent-4-en-2-yl)-1H-indole
• 英文别名: 4,6-Dimethoxy-7-(1-nitropent-4-en-2-yl)-2,3-diphenyl-1-prop-2-enylindole；4,6-dimethoxy-7-(1-nitropent-4-en-2-yl)-2,3-diphenyl-1-prop-2-enylindole
• CAS: 1220960-55-3
• 化学式: C₃₀H₃₀N₂O₄
• 分子量: 482.579
• InChiKey: IKVGTZYXARGXJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  36
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  69.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-allyl-4,6-dimethoxy-2,3-diphenyl-7-(1-nitropent-4-en-2-yl)-1H-indole 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 作用下， 以 甲苯 为溶剂， 反应 4.0h， 生成 1,3-dimethoxy-11-(nitromethyl)-4,5-diphenyl-10,11-dihydro-7H-azocino[3,2,1-hi]indole
  参考文献：
  名称：

  Ring closing metathesis strategies towards functionalised 1,7-annulated 4,6-dimethoxyindoles

  摘要：

  A ring closing metathesis approach has been used to prepare a novel range of indoles 1,7-annulated with nitromethyl and lactone functionalised medium-sized rings. Initial studies into the preparation of lactam functionalised rings are also discussed. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.04.019
• 作为产物：
  描述：

  4,6-dimethoxy-2,3-diphenyl-1-(prop-2'-enyl)indole-7-carbaldehyde 在 ammonium acetate 作用下， 以 四氢呋喃 、 异丙醇 为溶剂， 反应 21.0h， 生成 1-allyl-4,6-dimethoxy-2,3-diphenyl-7-(1-nitropent-4-en-2-yl)-1H-indole
  参考文献：
  名称：

  Ring closing metathesis strategies towards functionalised 1,7-annulated 4,6-dimethoxyindoles

  摘要：

  A ring closing metathesis approach has been used to prepare a novel range of indoles 1,7-annulated with nitromethyl and lactone functionalised medium-sized rings. Initial studies into the preparation of lactam functionalised rings are also discussed. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.04.019

文献信息

• Synthesis of novel 1,7-annulated 4,6-dimethoxyindoles
  作者：Kasey Wood、David StC Black、Irishi N.N. Namboothiri、Naresh Kumar

  DOI：10.1016/j.tetlet.2010.01.076

  日期：2010.3

  A range of new 1,7-annulated indole derivatives has been prepared via a ring-closing metathesis approach starting from N-allyl-7-formyl indoles. (C) 2010 Elsevier Ltd. All rights reserved.