1,3-bis(benzo[d][1,3]dioxol-5-yl)urea | 342885-75-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 1,3-bis(benzo[d][1,3]dioxol-5-yl)urea
• 英文别名: N,N'-bis-benzo[1,3]dioxol-5-yl-urea；N,N'-Bis-benzo[1,3]dioxol-5-yl-harnstoff；1,3-bis(3,4-methylenedioxyphenyl)urea；N,N'-bis(1,3-benzodioxol-5-yl)urea；1,3-bis(1,3-benzodioxol-5-yl)urea
• CAS: 342885-75-0
• 化学式: C₁₅H₁₂N₂O₅
• mdl: MFCD04302455
• 分子量: 300.271
• InChiKey: SFNUQOFRUOOFRC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  78
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1,3-bis(benzo[d][1,3]dioxol-5-yl)urea 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以82%的产率得到1,3-bis(3,4-dihydroxyphenyl)urea
  参考文献：
  名称：

  [EN] COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES SUCH AS ALZHEIMER'S DISEASE, TYPE 2 DIABETES, AND PARKINSON'S DISEASE
  [FR] COMPOSES, COMPOSITIONS ET PROCEDES DE TRAITEMENT DE MALADIES AMYLOIDES ET DE SYNUCLEINOPATHIES, NOTAMMENT DE LA MALADIE D'ALZHEIMER, DU DIABETE DE TYPE 2 ET DE LA MALADIE DE PARKINSON

  摘要：

  双-和三-二羟基芳基化合物及其亚甲二氧基类似物和药用可接受酯，它们的合成，含有它们的药物组合物，以及它们在治疗淀粉样疾病，特别是Aß淀粉样病变，如阿尔茨海默病中观察到的，IAPP淀粉样病变，如2型糖尿病中观察到的，以及α-突触核病，如帕金森病中观察到的，以及用于制造用于此类治疗的药物。

  公开号：

  WO2003101927A1
• 作为产物：
  描述：

  甲基 1,3-苯并二恶唑-5-羧酸酯 在 一水合肼 、 溶剂黄146 、 xylene 、 sodium nitrite 作用下， 生成 1,3-bis(benzo[d][1,3]dioxol-5-yl)urea
  参考文献：
  名称：

  THE SYNTHESIS OF SOME NEW PHENYLURETHANS AS POTENTIAL LOCAL ANESTHETICS

  摘要：

  DOI：

  10.1021/jo01125a009

文献信息

• Palladium-Catalyzed Aerobic Oxidative Carbonylation of Amines Enables the Synthesis of Unsymmetrical N,N′-Disubstituted Ureas
  作者：Honglan Zeng、Hongyan Du、Wei Han、Xu Gong、Jie Zhang

  DOI：10.1055/a-1500-9673

  日期：2021.7

  A ligand-free palladium-catalyzed aerobic oxidative carbonylation of amines for the synthesis of ureas, particular unsymmetrically N,N′-disubstituted ureas, which cannot be accessed by any other palladium-catalyzed oxidative carbonylation of amines to date, is presented. An array of symmetrical and unsymmetrical ureas were straightforwardly synthesized by using inexpensive, readily available, stable

  提出了用于合成脲的无配体的钯催化的胺的好氧氧化羰基化反应，特别是不对称的N，N'-二取代的脲，迄今为止，其他任何钯催化的胺的氧化羰基化反应均无法获得。通过使用廉价，易于获得，稳定和安全的胺，在1个大气压下以良好或优异的收率直接合成了一系列对称和不对称的脲。这种新颖的方法采用氧气作为唯一氧化剂，为基于过渡金属的氧化剂系统提供了有吸引力的替代方法
• Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as Alzheimer's disease, type 2 diabetes, and parkinson's disease
  申请人：——

  公开号：US20040127555A1

  公开（公告）日：2004-07-01

  Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially A&bgr; amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.

  双和三羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，其合成方法，包含它们的药物组成物，以及它们在治疗淀粉样疾病中的应用，特别是Aβ淀粉样蛋白病，如阿尔茨海默病，IAPP淀粉样蛋白病，如2型糖尿病中观察到的，以及突触核蛋白病，如帕金森病中观察到的，以及用于制造此类治疗药物。
• Compounds, compositions and methods for the treatment of amyloid diseases such as systemic AA amyloidosis
  申请人：Snow D. Alan

  公开号：US20070225362A1

  公开（公告）日：2007-09-27

  Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, AA/SAA amyloidosis, such as observed in systemic AA amyloidosis and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.

  双羟基和三羟基芳基化合物及其甲氧基二氧杂环化物和药学上可接受的酯类，它们的合成，含有它们的制药组合物，以及它们在治疗淀粉样疾病，特别是阿尔茨海默病中观察到的Aβ淀粉样变性，IAPP淀粉样变性，例如在2型糖尿病中观察到的AA / SAA淀粉样变性，以及突触蛋白病，例如在帕金森病中观察到的应用，以及用于制造这种治疗药物。
• Compounds, compositions and methods for the treatment of synucleinopathies
  申请人：Esposito Luke

  公开号：US20070276034A1

  公开（公告）日：2007-11-29

  Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of synucleinopathies, such as Parkinson's disease, and the manufacture of medicaments for such treatment.

  双-和三-二羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，它们的合成，含有它们的制药组合物，以及它们在治疗突触核病，如帕金森病中的应用和制造用于这种治疗的药物。
• COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES SUCH AS ALZHEIMER'S DISEASE, TYPE 2 DIABETES, AND PARKINSON'S DISEASE
  申请人：Snow Alan D.

  公开号：US20090069432A1

  公开（公告）日：2009-03-12

  Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.

  双-和三-二羟基芳基化合物及其二氧化甲基类似物和药学上可接受的酯，它们的合成，含有它们的制药组合物，以及它们在治疗淀粉样疾病中的应用，尤其是Aβ淀粉样蛋白病，如阿尔茨海默病，IAPP淀粉样蛋白病，如2型糖尿病，以及突触核病，如帕金森病，和用于制造这种治疗药物。