ethyl (E)-2-phenylethenesulfonate | 14554-08-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl (E)-2-phenylethenesulfonate
• 英文别名: trans-2-Phenyl-aethen-1-sulfonsaeure-aethylester
• CAS: 14554-08-6
• 化学式: C₁₀H₁₂O₃S
• 分子量: 212.269
• InChiKey: LEDCJBCTEYLBJO-CMDGGOBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl (E)-2-phenylethenesulfonate 在 四丁基碘化铵 、 三苯基膦 、 氯化亚砜 作用下， 以 丙酮 、 二氯甲烷 为溶剂， 反应 0.17h， 生成 反-β-苯乙烯磺酰氯
  参考文献：
  名称：

  Synthesis of Natural Product-Inspired Inhibitors of Mycobacterium tuberculosis Mycothiol-Associated Enzymes: The First Inhibitors of GlcNAc-Ins Deacetylase

  摘要：

  Synthesis and evaluation of a chemical library of inhibitors of the mycothiol biosynthesis enzyme GlcNAc-Ins deacetylase (MshB) and the mycothiol-dependent detoxification enzyme mycothiol-S-conjugate amidase (MCA) from Mycobacterium tuberculosis are reported. The library was biased to include structural features of a group of natural products previously shown to competitively inhibit MCA. Molecular docking studies that reproducibly placed the inhibitors in the active site of the enzyme MshB reveal the mode of binding and are consistent with observed biological activity.

  DOI：

  10.1021/jm070669h
• 作为产物：
  描述：

  ethyl (diethoxyphosphoryl)methanesulfonate 、 苯甲醛 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 5.25h， 以78%的产率得到ethyl (E)-2-phenylethenesulfonate
  参考文献：
  名称：

  Synthesis of Natural Product-Inspired Inhibitors of Mycobacterium tuberculosis Mycothiol-Associated Enzymes: The First Inhibitors of GlcNAc-Ins Deacetylase

  摘要：

  Synthesis and evaluation of a chemical library of inhibitors of the mycothiol biosynthesis enzyme GlcNAc-Ins deacetylase (MshB) and the mycothiol-dependent detoxification enzyme mycothiol-S-conjugate amidase (MCA) from Mycobacterium tuberculosis are reported. The library was biased to include structural features of a group of natural products previously shown to competitively inhibit MCA. Molecular docking studies that reproducibly placed the inhibitors in the active site of the enzyme MshB reveal the mode of binding and are consistent with observed biological activity.

  DOI：

  10.1021/jm070669h

文献信息

• NOVEL POLYTHIOPHENE POLYANION COMPLEXES IN HOMOPOLAR ORGANIC SOLVENTS
  申请人：Loevenich Wilfried

  公开号：US20110168946A1

  公开（公告）日：2011-07-14

  The invention relates to novel polythiophene-polyanion complexes which are soluble or dispersible in nonpolar organic solvents, and to the use thereof.

  本发明涉及一种新型聚噻吩-聚阴离子复合物，其可溶于或分散于非极性有机溶剂中，并涉及其用途。
• HOLLOW POLYMER PARTICLE, COLORED HOLLOW POLYMER PARTICLE AND THEIR PRODUCTION METHODS
  申请人：KAWAMURA INSTITUTE OF CHEMICAL RESEARCH

  公开号：EP2009033A1

  公开（公告）日：2008-12-31

  The hollow polymer particles of the present invention comprise a shell wall having for a main component thereof a copolymer obtained by polymerizing a monomer group (I) including a radical polymerizable water-soluble monomer (A) and a radical polymerizable water-insoluble monomer (B), and have a thickness of the shell wall of 5 to 80 nm. In addition, in the hollow polymer particle production process of the present invention, a monomer group (I) including a radical polymerizable water-soluble monomer (A) and a radical polymerizable water-insoluble monomer (B) is radical- polymerized using a polymerization initiator in an aqueous medium.

  本发明的空心聚合物颗粒包括壳壁，壳壁的主要成分是通过聚合包括可自由基聚合的水溶性单体(A)和可自由基聚合的水不溶性单体(B)的单体基团(I)而得到的共聚物，壳壁的厚度为5至80纳米。此外，在本发明的空心聚合物颗粒生产工艺中，包括可自由基聚合的水溶性单体（A）和可自由基聚合的水不溶性单体（B）的单体基团（I）在水介质中使用聚合引发剂进行自由基聚合。
• ALLERGEN INHIBITOR, ALLERGEN-INHIBITING PRODUCT, ALLERGEN INHIBITION METHOD, AND USE AS ALLERGEN INHIBITOR
  申请人：Sekisui Chemical Co., Ltd.

  公开号：EP2243809A1

  公开（公告）日：2010-10-27

  The present invention provides an allergen inhibitor which effectively prevents allergens from reacting with specific antibodies, mitigates the allergic symptoms or prevents appearance thereof, and is less likely to cause unpredictable discoloration and discoloration under usual conditions. The allergen inhibitor of the present invention comprises an allergen-inhibiting compound including a linear polymer having at least one of substituents represented by the formulas (1) to (3) at a side chain. Thus, the allergen inhibitor of the present invention shows excellent allergen-inhibiting effects.

  本发明提供了一种过敏原抑制剂，它能有效防止过敏原与特异性抗体发生反应，减轻过敏症状或防止出现过敏症状，并且在通常条件下不易引起不可预测的变色和脱色。本发明的过敏原抑制剂包括一种过敏原抑制化合物，其中包括一种线性聚合物，其侧链上至少有一个由式（1）至（3）所代表的取代基。因此，本发明的过敏原抑制剂具有极佳的过敏原抑制效果。
• Organic electronics with improved stability and performance
  申请人：BASF SE

  公开号：EP2336255A1

  公开（公告）日：2011-06-22

  Disclosed is a process for the preparation of an electronic device comprising a layer of a conductive (co)polymer or blend wherein anionic polysulfonate moieties are combined with cationic moieties selected from polythiophenes, polypyrroles and/or polyanilines, which process comprises addition of a tertiary amine to the aqueous solution or dispersion of the polymer's acidic form, and application of the thus neutralized polymer or polymer blend by a suitable method to form a layer. Especially advantageous for use in this process are conductive copolymers or blends of this class, which are water soluble, and whose anionic part is a copolymer combining sulfonic recurring structural units derived from vinylbenzenesulfonic, C2-C8alkenylsulfonic, (meth)acryloyloxy-C2-C8alkyl-sulfonic, (meth)acryloylamido-C2-C8alkyl-sulfonic acid or salts or mixtures thereof, with at least 10% b.w. recurring structural units of polyethylenglycol-acrylate and/or polyethylenglycol-methacrylate. The devices based on conductive layers obtained according to the present method, as well as the conductive polymers and layers themselves, show improved durability and performance features.

  本发明公开了一种制备电子设备的工艺，该设备包含一层导电（共）聚合物或混合物，其中阴离子聚磺酸盐分子与阳离子分子结合，阳离子分子选自聚噻吩、聚吡咯和/或聚苯胺，该工艺包括在聚合物酸性形式的水溶液或分散液中添加叔胺，并通过适当的方法将由此中和的聚合物或聚合物混合物应用于形成层。特别适用于该工艺的是水溶性导电共聚物或混合物，其阴离子部分是由乙烯基苯磺酸、 C2-C8 烷基磺酸、(甲基)丙烯酰氧基-C2-C8 烷基磺酸、(甲基)丙烯酰氨基-C2-C8 烷基磺酸或其盐或混合物衍生的磺酸重复结构单元与至少 10% b. w. 重复结构单元的共聚物。w. 聚乙二醇-丙烯酸酯和/或聚乙二醇-甲基丙烯酸酯的重复结构单元。 根据本发明方法获得的基于导电层的设备以及导电聚合物和导电层本身都具有更好的耐久性和性能特点。
• INSOLUBLE CARRIER FOR USE IN ANTI-PHOSPHOLIPID ANTIBODY MEASUREMENT REAGENT, ANTI-PHOSPHOLIPID ANTIBODY MEASUREMENT REAGENT, AND METHOD FOR MEASURING ANTI-PHOSPHOLIPID ANTIBODY
  申请人：Sekisui Medical Co., Ltd.

  公开号：EP2352029A1

  公开（公告）日：2011-08-03

  The present invention has an object to provide an insoluble carrier for an antiphospholipid antibody detection reagent having a high reactivity. The present invention also has an object to provide an antiphospholipid antibody detection reagent, and a method of detecting an antiphospholipid antibody. The present invention directs to an insoluble carrier for an antiphospholipid antibody detection reagent, having a zeta potential of lower than -45 mV in the case that the insoluble carrier is suspended in a 20 mmol/L aqueous sodium phosphate solution with a pH of 7.4 so that the resulting suspension has a solids concentration of 0.1%.

  本发明的目的是为具有高反应性的抗磷脂抗体检测试剂提供一种不溶性载体。本发明的另一个目的是提供一种抗磷脂抗体检测试剂和一种检测抗磷脂抗体的方法。本发明涉及一种用于抗磷脂抗体检测试剂的不溶性载体，当该不溶性载体悬浮于 20 mmol/L 的磷酸二氢钠水溶液（pH 值为 7.4）中，使悬浮液的固体浓度为 0.1%时，其 zeta 电位低于-45 mV。