methacrylic acid-(2-ureido-ethyl ester) | 4206-97-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methacrylic acid-(2-ureido-ethyl ester)
• 英文别名: (2-Methacryloyloxy-aethyl)-harnstoff；Methacrylsaeure-(2-ureido-aethylester)；2-(Carbamoylamino)ethyl 2-methylprop-2-enoate
• CAS: 4206-97-7
• 化学式: C₇H₁₂N₂O₃
• 分子量: 172.184
• InChiKey: LECNYTOLLNCBBO-UHFFFAOYSA-N

物化性质

• 熔点：
  77-78 °C
• 沸点：
  289.7±32.0 °C(Predicted)
• 密度：
  1.132±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  81.4
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2924199090

反应信息

• 作为反应物：
  描述：

  methacrylic acid-(2-ureido-ethyl ester) 、 草酸醛 生成 2-(4,5-Dihydroxy-2-oxoimidazolidin-1-yl)ethyl 2-methylprop-2-enoate
  参考文献：
  名称：

  IOVINE, C. P.;PALMER, J. G.;WALKER, J. L.

  摘要：

  DOI：
• 作为产物：
  描述：

  甲基丙烯酸异氰基乙酯 在 ammonium hydroxide 作用下， 以 水 为溶剂， 生成 methacrylic acid-(2-ureido-ethyl ester)
  参考文献：
  名称：

  [EN] MONOMERS, POLYMERS, AND ARTICLES FOR BIOMATERIAL CAPTURE
  [FR] MONOMÈRES, POLYMÈRES ET ARTICLES POUR LA CAPTURE DE BIOMATÉRIAUX

  摘要：

  单体，由这些单体形成的聚合物以及包括这些聚合物的生物材料捕获物品，其中单体由以下通用式（I）表示：CH2 = CR1-C（= O）-X-R2-Z-X3-NR3-C（= X2）-X1-R4，其中：R1为H或-CH3; R2是（杂）烃基; X是-O-或-NH-; X1是-O-，-S-，-NH-或单键; X2是-O-或-S-; X3是-O-或-NR5-; R4是氢，（杂）烃基或-N（R3）2; 每个R3和R5独立地是氢或（杂）烃基; Z是-C（= O）-或-NH-C（= O）-。

  公开号：

  WO2021209859A1

文献信息

• Polymer with upper critical solution temperature
  申请人：THE BOEING COMPANY

  公开号：US20200361859A1

  公开（公告）日：2020-11-19

  Aspects generally relate to a temperature responsive polymer, more specifically to a polymer exhibiting an upper critical solution temperature (UCST) in an aqueous solution. In one aspect, a monomer compound includes one or more amide or thioamide groups; one or more ureido or thioureido groups; and one or more ethylenically unsaturated groups. In one aspect, a polymer, such as a homopolymer or a copolymer, is produced by polymerization of the monomer compound. The copolymer is produced by polymerization of the monomer compound and a comonomer, such as a hydrophobic comonomer, a hydrophilic comonomer, a pH responsive comonomer, a light responsive comonomer, and combinations thereof. The polymer exhibits a UCST from about 1° C. to about 100° C. in an aqueous solution at 1 atm.

  方面通常涉及温度响应聚合物，更具体地是在水溶液中表现出上临界溶液温度（UCST）的聚合物。在一个方面，单体化合物包括一个或多个酰胺或硫酰胺基团；一个或多个脲基或硫脲基团；和一个或多个乙烯不饱和基团。在一个方面，通过单体化合物的聚合制备聚合物，如均聚物或共聚物。共聚物是通过单体化合物和共聚单体（如疏水性共聚单体、亲水性共聚单体、pH响应共聚单体、光响应共聚单体及其组合）的聚合制备的。在1个大气压下，聚合物在水溶液中表现出从约1°C到约100°C的UCST。
• Block ethylenic copolymers comprising a vinyllactam block, cosmetic or pharmaceutical compositions containing them and cosmetic use of these copolymers
  申请人：Mougin Nathalie

  公开号：US20060088487A1

  公开（公告）日：2006-04-27

  Disclosed herein are a linear block ethylenic copolymer comprising: at least one block A obtained from monomers comprising from 52% to 99% by weight of at least one ethylenic monomer comprising a lactam ring, of formula (I): and from 1% to 48% by weight of at least one ionic hydrophilic monomer; and at least one block B obtained from monomers not comprising an ethylenic monomer comprising a lactam ring of formula (I), or comprising a minor proportion thereof; a cosmetic or pharmaceutical composition, such as a hair composition, comprising the copolymer; a cosmetic process for making up or caring for keratin materials, comprising applying to the keratin materials the composition; and other uses of the copolymer.

  本文揭示了一种线性块状乙烯共聚物，包括：至少一种A块，其由包含至少一种含有内酰胺环的乙烯单体的重量为52%至99%的单体和含有至少一种离子亲水性单体的重量为1%至48%的单体得到；以及至少一种B块，其由不包含内酰胺环的乙烯单体或含有该单体的少量比例的单体得到；一种化妆品或药用组合物，如头发组合物，包括该共聚物；一种用于化妆或护理角蛋白材料的化妆过程，包括将该组合物涂抹到角蛋白材料上；以及该共聚物的其他用途。
• Design, synthesis and biological evaluation of new parbendazole derivatives for the treatment of HNSCC
  作者：Dong Liang、Chen Yu、Zhao Ma、Mingzhao Hu、Jiahui Wang、Xuhui Dong、Lupei Du、Minyong Li

  DOI：10.1016/j.ejmech.2022.114450

  日期：2022.8

  therapy candidate in our research. Herein, we report the discovery of two series of parbendazole derivatives as tubulin inhibitors. Structure-activity relationship (SAR) analyses led to the discovery of compound 9q with the best pharmacological activities and pharmacokinetic properties. This compound exhibited reasonable inhibition activity on cell proliferation (HN6, CAL-27, Fadu) and tubulin polymerization

  头颈部鳞状细胞癌（HNSCC）是一种预后极差的致死性疾病，每年新增病例超过 90 万例，死亡病例达 50 万例，但其药物治疗相当有限。在我们的研究中，帕苯达唑之前被确定为潜在的 HNSCC 治疗候选者。在此，我们报告了两个系列帕苯达唑衍生物作为微管蛋白抑制剂的发现。构效关系 (SAR) 分析导致发现了具有最佳药理活性和药代动力学特性的化合物9q 。该化合物对细胞增殖（HN6、CAL-27、Fadu）和微管蛋白聚合具有合理的抑制活性，诱导细胞凋亡，阻断细胞周期，抑制细胞迁移和侵袭。化合物9q还显示出低毒性和对异种移植肿瘤的良好治疗效果，表明它是进一步研究的有希望的起点。
• Process for synthesis of polymer compositions, polymer compositions obtainable by the process, and use of the same
  申请人：RohMax Additives GmbH

  公开号：US20030060587A1

  公开（公告）日：2003-03-27

  The present invention relates to a process for synthesis of polymer compositions with reduced catalyst content, wherein ethylenically unsaturated monomers containing less than 0.5 wt % of ethylenically unsaturated monomers with at least one carboxylic group, sulfonic acid group and/or at least one phosphonic acid group relative to the total weight of the ethylenically unsaturated monomers are polymerized by means of initiators containing a transferable group of atoms and of one or more catalysts comprising at least one transition metal in the presence of ligands which can form a coordination compound with the metal catalyst or catalysts and, after the polymerization, the catalyst contained in the polymer is at least partly separated. For this purpose, the polymer composition is filtered, after the polymerization, in the presence of at least one filter aid which contains at least 0.5 wt%, relative to the total weight of the filter aid, of repeating units that contain at least one carboxylic acid group, sulfonic acid group and/or at least one phosphonic acid group.

  本发明涉及一种合成聚合物组合物的过程，其具有降低催化剂含量的效果。在该过程中，含有少于0.5重量％的至少含有一个羧基，磺酸基和/或至少一个膦酸基的乙烯基不饱和单体相对于乙烯基不饱和单体的总重量进行聚合，通过含有可转移原子团的引发剂和至少一种过渡金属的催化剂，在与可以形成与金属催化剂或催化剂配合物的配体一起的情况下进行聚合，在聚合之后，聚合物中的催化剂至少部分被分离。为此，在聚合之后，通过至少一种过滤助剂过滤聚合物组合物，该过滤助剂相对于总重量含有至少0.5重量％的重复单元，其中包含至少一个羧酸基，磺酸基和/或至少一个膦酸基。
• Controlled free radical emulsion and water-based polymerizations and seeded methodologies
  申请人：——

  公开号：US20020013430A1

  公开（公告）日：2002-01-31

  Nitroxides having an alpha-carbon atom with a destabilizing moiety are effective control agents for emulsion and water-based polymerizations, including the formation of block copolymers from a wide range of monomers. The nitroxide radicals may be used as a free radical or as an adduct with a residue from the initiator. The emulsions have living characteristics, including the re-initiation of polymer chains. Also, a seeded process for emulsions, which includes the step-wise addition of monomer is disclosed, providing access to a wide range of initiator types.

  具有不稳定基团的α-碳原子的亚硝基自由基是乳液和水基聚合物的有效控制剂，包括从各种单体形成嵌段共聚物。亚硝基自由基可以作为自由基或与引发剂残基结合物一起使用。乳液具有活性特征，包括聚合物链的重新起始。此外，还公开了一种种子法乳液过程，其中包括逐步添加单体的步骤，从而提供了对各种引发剂类型的访问。