3-(7-chloroheptyl)pyridine | 107071-90-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-(7-chloroheptyl)pyridine
• CAS: 107071-90-9
• 化学式: C₁₂H₁₈ClN
• 分子量: 211.735
• InChiKey: WIDIOWRWIZLHGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-(7-chloroheptyl)pyridine 在 盐酸 作用下， 以 二甲基亚砜 为溶剂， 反应 75.0h， 生成 8-(3-pyridyl)octanoic acid hydrochloride
  参考文献：
  名称：

  Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives

  摘要：

  The enzyme thromboxane (TX) synthetase is inhibited by pyridine. The beta-substituted pyridine derivatives showed higher inhibitory potency than the gamma-substituted ones having the same side chain. Among the beta-substituted derivatives containing the omega-carboxyalkyl group, the compounds with 6-8 carbon atoms in the side chain were especially effective. The derivatives holding the phenylene group in the side chain exhibited much higher inhibitory activity than those of the alkylene type. Among them, (E)-3-[4-(3-pyridylmethyl)phenyl]-2-methylacrylic acid hydrochloride (5a) had the highest potency (IC50 = 3 x 10(-9) M). The beta-substituted pyridine derivatives and 1-substituted imidazole derivatives which had the same side chain showed almost the same potency. The beta-substituted pyridine derivatives do not inhibit arachidonic acid cyclooxygenase or prostaglandin I2 synthetase, two other enzymes of the arachidonic cascade.

  DOI：

  10.1021/jm00142a006
• 作为产物：
  描述：

  5-(吡啶-3-基)戊酸乙酯 在 palladium on activated charcoal 氯化亚砜 、 氢气 、 sodium hydride 、 二异丁基氢化铝 作用下， 以 乙醇 、 甲苯 为溶剂， 反应 3.67h， 生成 3-(7-chloroheptyl)pyridine
  参考文献：
  名称：

  Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives

  摘要：

  The enzyme thromboxane (TX) synthetase is inhibited by pyridine. The beta-substituted pyridine derivatives showed higher inhibitory potency than the gamma-substituted ones having the same side chain. Among the beta-substituted derivatives containing the omega-carboxyalkyl group, the compounds with 6-8 carbon atoms in the side chain were especially effective. The derivatives holding the phenylene group in the side chain exhibited much higher inhibitory activity than those of the alkylene type. Among them, (E)-3-[4-(3-pyridylmethyl)phenyl]-2-methylacrylic acid hydrochloride (5a) had the highest potency (IC50 = 3 x 10(-9) M). The beta-substituted pyridine derivatives and 1-substituted imidazole derivatives which had the same side chain showed almost the same potency. The beta-substituted pyridine derivatives do not inhibit arachidonic acid cyclooxygenase or prostaglandin I2 synthetase, two other enzymes of the arachidonic cascade.

  DOI：

  10.1021/jm00142a006

文献信息

• DI-SUBSTITUTED PYRIDINUM POLYMERS AND SYNTHESIS THEREOF
  申请人：Jaspars Marcel

  公开号：US20120123113A1

  公开（公告）日：2012-05-17

  A method of producing a di-substituted pyridinium polymer by microwave-assisted polymerisation of a 2, 3, or 4-substituted pyridine monomer of the formula NC 5 R 4 —R′—X, wherein R is selected from hydrogen, hydroxyl, and substituted or unsubstituted alkyl, alkoxy, aryl, alkaryl, aralkyl, and alkenyl groups, R′ is a linking group, and X is a leaving group. Using this method, di-substituted pyridinium polymer compositions may be obtained wherein at least 50% of the di- substituted pyridinium polymer chains in the composition have the same degree of polymerisation.

  利用微波辅助聚合2、3或4-取代吡啶单体NC5R4—R′—X，其中R选自氢、羟基和取代或未取代的烷基、烷氧基、芳基、烷芳基、芳基烷基和烯基基团，R′是连接基团，X是离去基团的方法，可以生产二取代吡啶聚合物。利用这种方法，可以获得二取代吡啶聚合物组合物，其中组合物中至少50%的二取代吡啶聚合物链具有相同的聚合度。
• N-substituierte Diphenylpiperidine
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0221376A2

  公开（公告）日：1987-05-13

  Die neuen N-substituierte Diphenylpiperidine der Formel worin R¹ CH, C=CH oder CH-CH₂ R² Alkylen oder CO-(CH₂)n, n 0 bis 11, R³ und R⁴ Wasserstoff, Halogen oder nieder-Alkoxy, Het Pyridyl, Pyrimidinyl oder Imidazolyl sind, und Salze davon mit pharmazeutisch verwendbaren Säuren können zur Senkung des Insulinspiegels und zur Behandlung von Obesitas verwendet werden. Mann kann sie ausgehend von entsprechenden N-unsubstituierten Diphenylpiperidinen herstellen.

  新的 N-取代二苯基哌啶，其式如下 其中 R¹ 是 CH、C＝CH 或 CH-CH₂ R² 烷基或 CO-(CH₂)n，n 0 至 11、 R³ 和 R⁴ 氢、卤素或低级烷氧基、 Het 为吡啶基、嘧啶基或咪唑基、 及其与药用酸的盐类可用于降低胰岛素水平和治疗肥胖症。它们可由相应的 N-未取代二苯基哌啶制备而成。
• TANOUCHI, TADAO;KAWAMURA, MASANORI;OHYAMA, ISAO;KAJIWARA, IKUO;IGUCHI, YO+, J. MED. CHEM., 1981, 24, N 10, 1149-1155
  作者：TANOUCHI, TADAO、KAWAMURA, MASANORI、OHYAMA, ISAO、KAJIWARA, IKUO、IGUCHI, YO+

  DOI：——

  日期：——
• DI-SUBSTITUTED PYRIDINIUM POLYMERS AND SYNTHESIS THEREOF
  申请人：University Court Of The University Of Aberdeen

  公开号：EP2430074A1

  公开（公告）日：2012-03-21
• US4632925A
  申请人：——

  公开号：US4632925A

  公开（公告）日：1986-12-30