5-Amino-2-methylindan | 54553-61-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 5-Amino-2-methylindan
• 英文别名: 2-methyl-2,3-dihydro-1H-inden-5-amine
• CAS: 54553-61-6
• 化学式: C₁₀H₁₃N
• mdl: MFCD19205362
• 分子量: 147.22
• InChiKey: RHTWKRPBLSOPBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5-Amino-2-methylindan 在 盐酸 、 硝酸 、 三氟乙酸 、 sodium nitrite 作用下， 以 1,4-二氧六环 、 乙醇 、 水 为溶剂， 反应 32.5h， 生成 3-chloro-7-methyl-7,8-dihydro-6H-indeno[5,6-e][1,2,4]triazine 1-oxide
  参考文献：
  名称：

  WO2006/104406

  摘要：

  公开号：
• 作为产物：
  描述：

  2-methyl-6-nitro-2,3-dihydro-1H-inden-1-one 在 盐酸 、 palladium on activated charcoal 、 氢气 作用下， 以 乙醇 、 水 为溶剂， 反应 16.0h， 生成 5-Amino-2-methylindan
  参考文献：
  名称：

  Tricyclic [1,2,4]Triazine 1,4-Dioxides As Hypoxia Selective Cytotoxins

  摘要：

  A series of novel tricyclic triazine-di-N-oxides (TTOs) related to tirapazamine have been designed and prepared. A wide range of structural arrangements with cycloalkyl, oxygen-, and nitrogen-containing Saturated rings fused to the triazine core, coupled with various side chains linked to either hemisphere, resulted in TTO analogues that displayed hypoxia-selective cytotoxicity in vitro. Optimal rates of hypoxic metabolism and tissue diffusion coefficients were achieved with fused cycloalkyl rings in combination with both the 3-aminoalkyl or 3-alkyl substituents linked to weakly basic soluble amines. The selection was further refined 7 using pharmacokinetic/phamacodynamic model predictions of the in vivo hypoxic potency (AUC(req)) and selectivity (HCD) with 12 TTO analogues predicted to be active in Vivo, Subject to the achievement of adequate plasma pharmacokinetics.

  DOI：

  10.1021/jm800967h

文献信息

• [EN] TGFBETAR1 INHIBITOR-ASGR ANTIBODY CONJUGATES AND USES THEREOF<br/>[FR] CONJUGUÉS INHIBITEUR DE TGFBETAR1-ANTICORPS ANTI-ASGR ET UTILISATIONS ASSOCIÉES
  申请人：SILVERBACK THERAPEUTICS INC

  公开号：WO2021072203A1

  公开（公告）日：2021-04-15

  Various conjugates and compositions thereof are disclosed for use in the treatment of a liver disease, such as liver cancer and liver fibrosis. The compositions comprise conjugates, wherein the conjugates are comprised of an antibody or antibody construct specific for ASGR1 or ASGR2 attached to a TGFβR1 inhibitor via a linker. Additionally provided are the methods of preparation of the conjugates and compositions thereof.

  本发明揭示了用于治疗肝病（如肝癌和肝纤维化）的各种共轭物和其组合物。这些组合物包括共轭物，其中共轭物由特异于ASGR1或ASGR2的抗体或抗体构造物通过连接剂连接到TGFβR1抑制剂上。此外，还提供了这些共轭物和组合物的制备方法。
• [EN] ALK5 INHIBITORS, CONJUGATES, AND USES THEREOF<br/>[FR] INHIBITEURS D'ALK5, CONJUGUÉS ET LEURS UTILISATIONS
  申请人：SILVERBACK THERAPEUTICS INC

  公开号：WO2019195278A1

  公开（公告）日：2019-10-10

  Compounds, conjugates and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed compounds may be useful, among other things, in treating of cancer and inhibiting ALK5. Compounds incorporated into a conjugate with an antibody construct are also described herein.

  本文披露了用于治疗疾病（如癌症）的化合物、共轭物和药物组合物。所披露的化合物可能在治疗癌症和抑制ALK5等方面具有用途。本文还描述了与抗体构造物结合的化合物。
• USE OF A CHEMICAL MECHANICAL POLISHING (CMP) COMPOSITION FOR POLISHING OF COBALT COMPRISING SUBSTRATES
  申请人：BASF SE

  公开号：EP3334794A1

  公开（公告）日：2018-06-20
• [EN] USE OF A CHEMICAL MECHANICAL POLISHING (CMP) COMPOSITION FOR POLISHING OF COBALT COMPRISING SUBSTRATES<br/>[FR] UTILISATION D'UNE COMPOSITION DE POLISSAGE CHIMICO-MÉCANIQUE (CMP) POUR LE POLISSAGE DE SUBSTRATS COMPRENANT DU COBALT
  申请人：BASF SE

  公开号：WO2017025536A1

  公开（公告）日：2017-02-16

  Use of a chemical mechanical polishing (CMP) composition (Q) for chemical mechanical polishing of a substrate (S) comprising (i) cobalt and/or (ii) a cobalt alloy and (iii) Ti N and /or TaN, wherein the CMP composition (Q) comprises (E) Inorganic particles (F) at least one organic compound comprising an amino-group and an acid group (Y), wherein said compound comprises n amino groups and at least n+1 acidic protons, wherein n is a integer ≥ 1. (G) at least one oxidizer in an amount of from 0.2 to 2.5 wt.-% based on the total weight of the respective CMP composition, (H) an aqueous medium wherein the CMP composition (Q) has a pH of more than 6 and less than 9.
• WO2006/104406
  申请人：——

  公开号：——

  公开（公告）日：——