tert-butyl (2S)-2-[(1R)-1-benzoyloxy-2-[tert-butyl(dimethyl)silyl]oxyethyl]aziridine-1-carboxylate | 412960-86-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl (2S)-2-[(1R)-1-benzoyloxy-2-[tert-butyl(dimethyl)silyl]oxyethyl]aziridine-1-carboxylate
• CAS: 412960-86-2
• 化学式: C₂₂H₃₅NO₅Si
• 分子量: 421.609
• InChiKey: UHFZQSOSVIXIAH-JOHXPNBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.85
• 重原子数：
  29
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  64.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  tert-butyl (2S)-2-[(1R)-1-benzoyloxy-2-[tert-butyl(dimethyl)silyl]oxyethyl]aziridine-1-carboxylate 在 吡啶 、 copper(I) bromide dimethylsulfide complex 、 氢氟酸 、 caesium carbonate 作用下， 以 甲醇 、 乙腈 为溶剂， 生成 (R)-1-[(S)-1-(tert-butoxycarbonylamino)-3-methylbutyl]oxirane
  参考文献：
  名称：

  Synthesis of statine employing a general syn-amino alcohol building block

  摘要：

  An orthogonally protected syn-2-amino-1,3,4-butanetriol has been employed as a general syn-amino alcohol building block in the synthesis of statine. This synthesis demonstrates the utility of the building block in the synthesis of any syn-amino alcohol compound. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)02206-7
• 作为产物：
  描述：

  (2S,3R)-O(1)-benzyl-N(2)-(tert-butoxycarbonyl)-O(3)-benzoyl-O(4)-(tert-butyldimethylsilyl)-2-amino-1,3,4-butanetriol 在 palladium on activated charcoal 吡啶 、 氢气 、 sodium hydride 作用下， 生成 tert-butyl (2S)-2-[(1R)-1-benzoyloxy-2-[tert-butyl(dimethyl)silyl]oxyethyl]aziridine-1-carboxylate
  参考文献：
  名称：

  Synthesis of statine employing a general syn-amino alcohol building block

  摘要：

  An orthogonally protected syn-2-amino-1,3,4-butanetriol has been employed as a general syn-amino alcohol building block in the synthesis of statine. This synthesis demonstrates the utility of the building block in the synthesis of any syn-amino alcohol compound. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)02206-7

文献信息

• Synthesis of statine employing a general syn-amino alcohol building block
  作者：Soon Ji Kwon、Soo Y Ko

  DOI：10.1016/s0040-4039(01)02206-7

  日期：2002.1

  An orthogonally protected syn-2-amino-1,3,4-butanetriol has been employed as a general syn-amino alcohol building block in the synthesis of statine. This synthesis demonstrates the utility of the building block in the synthesis of any syn-amino alcohol compound. (C) 2002 Elsevier Science Ltd. All rights reserved.