2-(4-Nitrophenyl)sulfonyl-5-phenyl-3,4-dihydropyrazole | 1158827-58-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-Nitrophenyl)sulfonyl-5-phenyl-3,4-dihydropyrazole
• CAS: 1158827-58-7
• 化学式: C₁₅H₁₃N₃O₄S
• 分子量: 331.352
• InChiKey: FFRIFSZHDAGIJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  104
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-phenyl-4,5-dihydro-1H-pyrazole 、 对硝基苯磺酰氯 在 吡啶 作用下， 反应 0.33h， 生成 2-(4-Nitrophenyl)sulfonyl-5-phenyl-3,4-dihydropyrazole
  参考文献：
  名称：

  Synthesis and antiviral activities of novel acylhydrazone derivatives targeting HIV-1 capsid protein

  摘要：

  HIV-1 capsid protein (CA) plays important roles in the viral replication cycle. A number of acylhydrazone derivatives that act as inhibitors of HIV-1 CA assembly, were designed and synthesized. The synthesized compounds were tested for their antiviral activities and cytotoxicities using CEM cells. Some derivatives also were assayed for their ability to inhibit HIV-1 CA assembly in vitro. Among them, compounds 14f and 14i display the most promising potency with EC50 values of 0.21 and 0.17 mu M, respectively. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.02.116

文献信息

• Synthesis and antiviral activities of novel acylhydrazone derivatives targeting HIV-1 capsid protein
  作者：Baohe Tian、Meizi He、Shixing Tang、Indira Hewlett、Zhiwu Tan、Jiebo Li、Yinxue Jin、Ming Yang

  DOI：10.1016/j.bmcl.2009.02.116

  日期：2009.4

  HIV-1 capsid protein (CA) plays important roles in the viral replication cycle. A number of acylhydrazone derivatives that act as inhibitors of HIV-1 CA assembly, were designed and synthesized. The synthesized compounds were tested for their antiviral activities and cytotoxicities using CEM cells. Some derivatives also were assayed for their ability to inhibit HIV-1 CA assembly in vitro. Among them, compounds 14f and 14i display the most promising potency with EC50 values of 0.21 and 0.17 mu M, respectively. (C) 2009 Elsevier Ltd. All rights reserved.