N-Methylleucinmethylester | 35026-08-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Methylleucinmethylester
• 英文别名: Pentanoic acid, 4-methyl-2-methylamino, methyl ester；methyl 4-methyl-2-(methylamino)pentanoate
• CAS: 35026-08-5；117710-31-3
• 化学式: C₈H₁₇NO₂
• mdl: MFCD12148934
• 分子量: 159.228
• InChiKey: NYXMJFGTJZTHPT-UHFFFAOYSA-N

物化性质

• 保留指数：
  1014

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氨基-4-甲基戊酸甲酯 在 三乙酰氧基硼氢化钠 、 溶剂黄146 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 3.0h， 生成 N-Methylleucinmethylester
  参考文献：
  名称：

  A General Inhibitor Scaffold for Serine Proteases with a (Chymo)trypsin-Like Fold:  Solution-Phase Construction and Evaluation of the First Series of Libraries of Mechanism-Based Inhibitors

  摘要：

  DOI：

  10.1021/ja990160e

文献信息

• Dextran functionalized by hydrophobic amino acids
  申请人：Soula Gerard

  公开号：US20080234227A1

  公开（公告）日：2008-09-25

  The invention relates to a dextran functionalized by at least one hydrophobic alpha-amino acid radical, said alpha-amino acid being grafted or bonded to the dextran by a bonding arm and a functional group. A hydrophobic amino acid radical is understood as being the product of coupling between the amine of the amino acid and an acid carried by the bonding arm, said dextran being amphiphilic at neutral pH. In an embodiment, the hydrophobic amino acid is selected from tryptophan derivatives, such as tryptophan, tryptophanol, tryptophanamide, 2-indole ethyl-amine and their alkaline cation salts. The present invention relates also to a pharmaceutical composition comprising one of the dextrans according to the invention.

  该发明涉及至少一个疏水性α-氨基酸基团功能化的葡聚糖，所述α-氨基酸通过一个连接臂和一个功能基团被嫁接或结合到葡聚糖上。疏水性氨基酸基团被理解为氨基酸的胺基与连接臂携带的酸之间的偶联产物，所述葡聚糖在中性pH下为两性的。在一种实施例中，疏水性氨基酸来自色氨酸衍生物，例如色氨酸、色氨醇、色氨酰胺、2-吲哚乙基胺及其碱性阳离子盐。本发明还涉及包含根据本发明的葡聚糖之一的药物组合物。
• CDDO-ME AMINO ACID CONJUGATES AND METHODS OF USE
  申请人：Trustees of Dartmouth College

  公开号：US20150225352A1

  公开（公告）日：2015-08-13

  2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid amino acid derivatives having antiinflammatory properties are provided. Pharmaceutical compositions and methods for preventing or treating inflammation or a disease or condition mediated by inflammation are described.

  提供具有抗炎作用的2-氰基-3,12-二氧杂环戊十三烷-1,9(11)-二烯-28-酸氨基酸衍生物。还描述了用于预防或治疗炎症或由炎症介导的疾病或状况的药物组合物和方法。
• PANAXDIOL-TYPE GINSENOSIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF
  申请人：Army Medical University

  公开号：EP3502120B1

  公开（公告）日：2022-05-25
• BIOLOGICALLY ABSORBABLE COATING FOR IMPLANTABLE DEVICES BASED ON COPOLYMERS HAVING ESTER BONDS AND METHODS OF FABRICATING THE SAME
  申请人：Abbott Cardiovascular Systems Inc.

  公开号：US20140147687A1

  公开（公告）日：2014-05-29

  Coatings for an implantable medical device and a method of fabricating thereof are disclosed, and the coatings comprise biologically absorbable poly(ester amides).
• US7704957B2
  申请人：——

  公开号：US7704957B2

  公开（公告）日：2010-04-27