1,3-dihydroxy-6-carboxyanthraquinone | 77332-39-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 1,3-dihydroxy-6-carboxyanthraquinone
• 英文别名: 5,7-Dihydroxy-9,10-dioxoanthracene-2-carboxylic acid
• CAS: 77332-39-9
• 化学式: C₁₅H₈O₆
• 分子量: 284.225
• InChiKey: JUDDKFRUWRCTDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,3-dihydroxy-6-carboxyanthraquinone 、 碘甲烷 在 silver(l) oxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 methyl 5.7-dimethoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate
  参考文献：
  名称：

  Cameron, Donald W.; Feutrill, Geoffrey I.; Patti, Antonio F., Australian Journal of Chemistry, 1980, vol. 33, # 7, p. 1805 - 1816

  摘要：

  DOI：
• 作为产物：
  描述：

  1,3-dihydroxy-6-methylanthraquinone 在 吡啶 、 chromium(VI) oxide 、 氢氧化钾 、 乙酸酐 、 溶剂黄146 作用下， 以 水 为溶剂， 反应 4.0h， 生成 1,3-dihydroxy-6-carboxyanthraquinone
  参考文献：
  名称：

  Cameron, Donald W.; Feutrill, Geoffrey I.; Patti, Antonio F., Australian Journal of Chemistry, 1980, vol. 33, # 7, p. 1805 - 1816

  摘要：

  DOI：

文献信息

• Rhein Conjugates, Preparation Method Thereof and Their Uses in Producing Medicines for Treating Diabetic Nephrosis, Intestinal Adhesion and Osteoarthritis
  申请人：Cong Xiaodong

  公开号：US20080207758A1

  公开（公告）日：2008-08-28

  The conjugates of present invention are formed by the combination of rhein or their analogues with the organic bases or amino acids in molecular force between them. The methods for preparing the conjugates and their uses for manufacturing medicines in the treatment of diabetic nephrosis, recovery of gastrointestinal function and prevention of intestinal adhesion, as well as treatment of osteoarthritis, rheumatic arthritis and rheumatoid arthritis are also described. Rhein or their analogues as the left part of general formula (I) is selected from (1) the compounds of rhein or their analogues, in which one or two substituents of R2˜R3 and R6˜R7 are COOH at least two substituents of R1˜8 are —H; or (2) the rhein-containing extract derived from plants. In general formula (I), M represents nitrogen-containing organic bases or basic amino acids.

  本发明的共轭物由大黄素或其类似物与有机碱或氨基酸在它们之间的分子力相互作用而形成。描述了制备这些共轭物的方法以及它们在制造治疗糖尿病性肾病、恢复胃肠功能和预防肠粘连，以及治疗骨关节炎、风湿性关节炎和类风湿性关节炎的药物中的用途。大黄素或其类似物作为通式（I）的左部分，从（1）大黄素或其类似物的化合物中选择，其中R2˜R3和R6˜R7的一个或两个取代基至少有两个R1˜8的取代基为—H；或（2）来自植物的含有大黄素的提取物。在通式（I）中，M代表含氮有机碱或碱性氨基酸。
• Method of inhibiting neurotrophin-receptor binding
  申请人：QUEEN'S UNIVERSITY AT KINGSTON

  公开号：EP1743886A1

  公开（公告）日：2007-01-17

  The present invention relates to compositions which inhibit the binding of nerve growth factor to the p75NTR common neurotrophin receptor and methods of use thereof. In one embodiment, the compound which inhibits binding of nerve growth factor to p75NTR comprises, particularly when bound to nerve growth factor, at least two of the following: (1) a first electronegative atom or functional group positioned to interact with Lys34 of nerve growth factor; (2) a second electronegative atom or functional group positioned to interact with Lys95 of nerve growth factor; (3) a third electronegative atom or functional group positioned to interact with Lys88 of nerve growth factor; (4) a fourth electronegative atom or functional group positioned to interact with Lys32 of nerve growth factor; and (5) a hydrophobic moiety which interacts with the hydrophobic region formed by Ile31, Phe101 and Phe86 of nerve growth factor.

  本发明涉及抑制神经生长因子与 p75NTR 常见神经营养素受体结合的组合物及其使用方法。在一个实施方案中，抑制神经生长因子与 p75NTR 结合的化合物包括（特别是当与神经生长因子结合时）以下至少两个：(1) 与神经生长因子的 Lys34 相互作用的第一电负性原子或官能团； (2) 与神经生长因子的 Lys95 相互作用的第二电负性原子或官能团； (3) 与神经生长因子的 Lys88 相互作用的第三电负性原子或官能团；(4) 与神经生长因子的 Lys32 相互作用的第四个电负性原子或官能团；以及 (5) 与神经生长因子的 Ile31、Phe101 和 Phe86 形成的疏水区域相互作用的疏水分子。
• RHEIN CONJUGATES, PREPARATION METHOD THEREOF AND THEIR USES IN PRODUCING MEDICINES FOR TREATING DIABETIC NEPHROSIS, INTESTINAL ADHESION AND OSTEOARTHRITIS
  申请人：Jiangsu Lianchuang Pharmaceutical Technology Co.

  公开号：EP1913940A1

  公开（公告）日：2008-04-23

  The conjugates of present invention are formed by the combination of rhein or their analogues with the organic bases or amino acids in molecular force between them. The methods for preparing the conjugates and their uses for manufacturing medicines in the treatment of diabetic nephrosis, recovery of gastrointestinal function and prevention of intestinal adhesion, as well as treatment of osteoarthritis, rheumatic arthritis and rheumatoid arthritis are also described. Rhein or their analogues as the left part of general formula (I) is selected from (1) the compounds of rhein or their analogues, in which one or two substituents of R2~R3 and R6~R7 are COOH at least two substituents of R1~8 are -H; or (2) the rhein-containing extract derived from plants. In general formula (I), M represents nitrogen-containing organic bases or basic amino acids.

  本发明的共轭物是由风湿素或其类似物与有机碱或氨基酸以分子间的作用力结合而成。本发明还描述了制备这些共轭物的方法及其在治疗糖尿病肾病、恢复胃肠功能和预防肠粘连以及治疗骨关节炎、风湿性关节炎和类风湿性关节炎方面的药物制造用途。作为通式（I）左侧部分的流苏素或其类似物选自（1）流苏素化合物或其类似物，其中 R2~R3 和 R6~R7 的一个或两个取代基为 COOH，R1~8 的至少两个取代基为 -H；或（2）从植物中提取的含流苏素的提取物。在通式（I）中，M 代表含氮有机碱或碱性氨基酸。
• CAMERON D. W.; FEUTRILL G. I.; PATTI A. F., AUSTRAL. J. CHEM., 1980, 33, NO 8, 1805-1816
  作者：CAMERON D. W.、 FEUTRILL G. I.、 PATTI A. F.

  DOI：——

  日期：——
• US9181172B2
  申请人：——

  公开号：US9181172B2

  公开（公告）日：2015-11-10