2,5-Dioxo-1-pyrrolidinyl 6-aminohexanoate | 104719-64-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2,5-Dioxo-1-pyrrolidinyl 6-aminohexanoate
• 英文别名: (2,5-dioxopyrrolidin-1-yl) 6-aminohexanoate
• CAS: 104719-64-4
• 化学式: C₁₀H₁₆N₂O₄
• 分子量: 228.248
• InChiKey: GJKXWRWXHBAIHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  89.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,5-Dioxo-1-pyrrolidinyl 6-aminohexanoate 在 3-吗啉丙磺酸 、 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下， 以 二甲基亚砜 、 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  NOVEL ACRYLATE DERIVATIVES AND USES THEREOF

  摘要：

  This disclosure relates to new cross-linking reagents for incorporating proteins and nucleic acids into polyelectrolyte gels, for use in expansion microscopy and other methods.

  公开号：

  US20230279476A1
• 作为产物：
  描述：

  叔丁氧羰酰基6-氨基己酸 在 1,2-二氯乙烷 、 三氟乙酸 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 2,5-Dioxo-1-pyrrolidinyl 6-aminohexanoate
  参考文献：
  名称：

  NOVEL ACRYLATE DERIVATIVES AND USES THEREOF

  摘要：

  This disclosure relates to new cross-linking reagents for incorporating proteins and nucleic acids into polyelectrolyte gels, for use in expansion microscopy and other methods.

  公开号：

  US20230279476A1

文献信息

• [EN] SPLICEOSTATIN ANALOGS<br/>[FR] ANALOGUES DE SPLICÉOSTATINE
  申请人：PFIZER

  公开号：WO2014068443A1

  公开（公告）日：2014-05-08

  The present invention is directed to novel cytotoxic spliceostatin analogs (I) and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.

  本发明涉及新型细胞毒性剪接抑制素类似物（I）及其衍生物，涉及其抗体药物结合物，以及使用它们治疗包括癌症在内的医疗状况的方法。
• AZACYANINE DYES AND USE THEREOF
  申请人：Ecole Polytechnique Fédérale de Lausanne (EPFL)

  公开号：US20180079906A1

  公开（公告）日：2018-03-22

  The application provides fluorescent dyes, which are cyanine dyes that incorporate additional aza moieties in the indolenium heterocycles and/or in the methine chains connecting them. Symmetrical and unsymmetrical chemically reactive azacyanine dyes are described for conjugation, as well as their bioconjugates for in-vitro and in-vivo assays and fluorescence imaging.

  该应用程序提供荧光染料，这些染料是氰染料，它们在吲哚啉环中和/或连接它们的亚甲链中包含额外的氮杂基。描述了用于共轭的对称和非对称化学反应性氮杂氰染料，以及它们的生物共轭物用于体外和体内分析和荧光成像。
• Regulators of the hedgehog pathway, compositions and uses related thereto
  申请人：Beachy A. Philip

  公开号：US20060128639A1

  公开（公告）日：2006-06-15

  The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function mutations.

  本发明提供了调节平滑蛋白依赖性通路激活的方法和试剂等。在某些实施例中，这些方法可用于对抗由于刺猬增强功能、ptc失去功能或平滑蛋白增强功能突变引起的刺猬通路不必要激活的表型效应。
• ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF
  申请人：Medarex, L.L.C.

  公开号：US20140323690A1

  公开（公告）日：2014-10-30

  Antiproliferative compounds having a structure represented by formula (II), where n, R 1 , R 2 , R 3 , R 4 , and R 5 are as defined herein, can be used to treat tumors, optionally when conjugated to a ligand such as an antibody:

  具有公式（II）所表示结构的抗增殖化合物，其中n，R1，R2，R3，R4和R5的定义如本文所述，可用于治疗肿瘤，可选择与配体（如抗体）结合使用：
• Non-nucleotide reagents for substituting termini of oligonucleotides
  申请人：M.L. TECHNOLOGY VENTURES, L.P.

  公开号：EP0310312A2

  公开（公告）日：1989-04-05

  A reagent which can couple with the 5' hydroxy position of a nucleotide, typically the terminal nucleotide in a nucleotide multimer, under the same conditions used in known standard solid-phase nucleotide multimer synthesis. When so coupled, the reagent produces a substituted nucleotide multimer with a protected linking moiety which is deprotected under the same alkaline conditions typically used to deprotect nucleotide exocyclic amines of a completed synthetic nucleotide multimer. A single one of the class of reagents can be so coupled to any nucleotide, and since the reagents have a non-nucleotide skeleton, the resulting substituted nucleotide multimer does not have an additional nucleotide which could potentially interfere with hybridization with a target nucleotide sequence.

  一种试剂，可在已知的标准固相核苷酸多聚物合成所用的相同条件下，与核苷酸（通常是核苷酸多聚物中的末端核苷酸）的 5'羟基位置偶联。当这种试剂与核苷酸多聚物偶联时，就会产生一种具有受保护连接分子的取代核苷酸多聚物，这种核苷酸多聚物在通常用于对已完成合成的核苷酸多聚物的核苷酸外环胺进行脱保护的相同碱性条件下进行脱保护。该类试剂中的一个试剂可与任何核苷酸连接，由于试剂具有非核苷酸骨架，因此产生的取代核苷酸多聚体没有可能干扰与目标核苷酸序列杂交的额外核苷酸。