(2S)-17-phenyl-4,7,10,13,16-pentaoxapentadecane-1,2-diol | 499136-64-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S)-17-phenyl-4,7,10,13,16-pentaoxapentadecane-1,2-diol
• 英文别名: (2S)-3-[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]propane-1,2-diol
• CAS: 499136-64-0
• 化学式: C₁₈H₃₀O₇
• 分子量: 358.432
• InChiKey: YONVDDLNWAQSLY-SFHVURJKSA-N

物化性质

• 沸点：
  496.2±40.0 °C(Predicted)
• 密度：
  1.139±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  25
• 可旋转键数：
  17
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  86.6
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (2S)-17-phenyl-4,7,10,13,16-pentaoxapentadecane-1,2-diol 在 palladium on activated charcoal 氢气 、 sodium hydride 作用下， 以 四氢呋喃 、 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 96.5h， 生成
  参考文献：
  名称：

  古细菌类似硫醇脂，用于超光滑金表面上的拴系双层脂质膜。

  摘要：

  DOI：

  10.1002/anie.200390080
• 作为产物：
  描述：

  三缩四乙二醇 在 4-二甲氨基吡啶 、 dowex 50Wx₈ 、 水 、 四丁基碘化铵 、 sodium hydride 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 N,N-二甲基甲酰胺 为溶剂， 反应 138.0h， 生成 (2S)-17-phenyl-4,7,10,13,16-pentaoxapentadecane-1,2-diol
  参考文献：
  名称：

  古细菌类似硫醇脂，用于超光滑金表面上的拴系双层脂质膜。

  摘要：

  DOI：

  10.1002/anie.200390080

文献信息

• New Deuterated Oligo(ethylene glycol) Building Blocks and Their Use in the Preparation of Surface Active Lipids Possessing Labeled Hydrophilic Tethers
  作者：Robert J. Faragher、Adrian L. Schwan

  DOI：10.1021/jo701979z

  日期：2008.2.1

  For the introduction of additional analysis protocols of tethered molecules, a method is presented to prepare functionalized, deuterated oligo(ethylene glycols) from ethylene glycol-d(4). Partial oligomerization of ethylene glycol-d(4) and conversion to ditosylates is accompanied by coupling reactions to prepare doubly benzyl protected oligo(ethylene glycols) with two to five repeating units. The tetramer bearing 16 deuteria was elaborated at both ends to eventually prepare 2,3-di-O-phytanyl-sn-glycerol-1-tetraethylene glycol-D,L-alpha-lipoic acid ester (DPTL), which bears a fully deuterated tetra(ethylene glycol) spacer group. Through linking of functionalized components, an analogue of DPTL possessing an octa(ethylene glycol) spacer group was prepared, both in deuterated and unlabeled form.
• [EN] LIPIDIC COMPOUNDS, AND USES THEREOF<br/>[FR] COMPOSÉS LIPIDIQUES ET LEURS UTILISATIONS
  申请人：[en]SANOFI

  公开号：WO2023135305A1

  公开（公告）日：2023-07-20

  The disclosure relates to lipidic compounds of formula (I): A-(CH2)n-CX-B-Z-R1 (I) wherein R1 represents a lipophilic or hydrophobic tail-group, wherein R1 is an optionally substituted, branched, saturated or unsaturated, C10to C55hydrocarbon radical, and which hydrocarbon skeleton that is optionally interrupted by one or several atoms of oxygen or nitrogen and/or one or several moiety –(C=O)-,-O-(C=O)- or –(C=O)-O- and which one nitrogen atom, if present in the skeleton, can be linked, directly or not, to said Z radical; Z is a spacer arm; B represents O or NH; X is O or S; n is 0, 1, 2, 3, 4, 5 or 6; and A represents (i) R2R3N-, (ii) NR2R3-Alk-Y- in which Y is O or N, Alk is an alkylene moiety in C2to C6and R2 and R3 represent independently of each other a linear or branched (C1-C6) alkyl group, or (iii) a 4- to 8-membered saturated heterocyclic radical comprising 3 to 7 carbon atoms and 1 or 2 nitrogen atoms, said 4- to 8-membered saturated heterocyclic radical being linked to the rest of the molecule by a carbon atom or a nitrogen atom and being optionally substituted by 1 to 4 substituents, independently of each other, selected from a linear or branched (C1-C6) alkyl group; or one of its pharmaceutically acceptable salts thereof; and with said compound that is in all the possible racemic, enantiomeric and diastereoisomeric isomer forms.
• Archaea Analogue Thiolipids for Tethered Bilayer Lipid Membranes on Ultrasmooth Gold Surfaces
  作者：Stefan M. Schiller、Renate Naumann、Katherine Lovejoy、Horst Kunz、Wolfgang Knoll

  DOI：10.1002/anie.200390080

  日期：2003.1.13