2',3'-dihydroxy-4'-methoxychalcone | 82964-33-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2',3'-dihydroxy-4'-methoxychalcone
• 英文别名: (E)-1-(2,3-dihydroxy-4-methoxyphenyl)-3-phenylprop-2-en-1-one
• CAS: 82964-33-8
• 化学式: C₁₆H₁₄O₄
• 分子量: 270.285
• InChiKey: SYVRRIJAJHSVEI-VQHVLOKHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2',3'-dihydroxy-4'-methoxychalcone 在 三氟化硼 作用下， 以 氯仿 为溶剂， 反应 24.0h， 生成 2'-(difluoroboryloxy)-3'-hydroxy-4'-methoxychalcone
  参考文献：
  名称：

  Starkov, S. P.; Polyanskaya, N. L.; Volkotrub, M. N., Journal of general chemistry of the USSR, 1982, vol. 52, # 6, p. 1214 - 1217

  摘要：

  DOI：
• 作为产物：
  描述：

  2'-(difluoroboryloxy)-3'-hydroxy-4'-methoxychalcone 在 水 作用下， 以 乙醇 为溶剂， 以86%的产率得到2',3'-dihydroxy-4'-methoxychalcone
  参考文献：
  名称：

  Starkov, S. P.; Polyanskaya, N. L.; Volkotrub, M. N., Journal of general chemistry of the USSR, 1982, vol. 52, # 6, p. 1214 - 1217

  摘要：

  DOI：

文献信息

• Starkov, S. P.; Plyanskaya, N. L.; Volkotrub, M. N., Journal of general chemistry of the USSR, 1982, vol. 52, p. 1214 - 1217
  作者：Starkov, S. P.、Plyanskaya, N. L.、Volkotrub, M. N.

  DOI：——

  日期：——
• ANTIBIOTIC COMPOUNDS THAT INHIBIT BACTERIAL PROTEIN SYNTHESIS
  申请人：The Board of Regents of the University of Texas System

  公开号：US20160220510A1

  公开（公告）日：2016-08-04

  An aminoacylation/translation (AIT) system based on the protein synthesis system from the pathogen Pseudomonas aeruginosa , was used to screen chemical compounds for identifying inhibitors of protein synthesis. This system includes elongation factors: EF-Tu, EF-Ts and EF-G, aminoacyl tRNA synthetase (aaRS) specific for phenylalanine, PheRS, and ribosomes isolated from cultures of Pseudomonas aeruginosa . Compounds identified using this assay have been shown to contain broad spectrum activity against both Gram+ and Gram− pathogens. Methods of using the identified compounds, as well as derivatives and analogues of these compounds, as antimicrobial agents against bacterial infections are described.
• Starkov, S. P.; Polyanskaya, N. L.; Volkotrub, M. N., Journal of general chemistry of the USSR, 1982, vol. 52, # 6, p. 1214 - 1217
  作者：Starkov, S. P.、Polyanskaya, N. L.、Volkotrub, M. N.

  DOI：——

  日期：——