4-(3,3-Diphenylpropylidene)-1-[3-(4-methoxyphenyl)propyl]piperidine | 191217-35-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(3,3-Diphenylpropylidene)-1-[3-(4-methoxyphenyl)propyl]piperidine
• CAS: 191217-35-3
• 化学式: C₃₀H₃₅NO
• 分子量: 425.614
• InChiKey: INHYDXFTQIQZGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(3,3-Diphenylpropylidene)-1-[3-(4-methoxyphenyl)propyl]piperidine 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 生成 4-(3,3-Diphenylpropyl)-1-[3-(4-methoxyphenyl)propyl]piperidine
  参考文献：
  名称：

  The SAR of UK-78,282: A novel blocker of human T cell Kv1.3 potassium channels

  摘要：

  UK-78,282 was identified in a human T cell Rb-86 efflux high-throughput screen of our compound libraries. This compound was found to be a potent and selective blacker of human T cell voltage-gated K+ channels and to inhibit T cell activation. The SAR around UK-78,282 and a general pharmacophore hypothesis are presented in this communication. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00163-7
• 作为产物：
  描述：

  4-甲氧基苯丙酰氯 在 锂硼氢 、 伯吉斯试剂 、 Swern reagents 、 TEA 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 生成 4-(3,3-Diphenylpropylidene)-1-[3-(4-methoxyphenyl)propyl]piperidine
  参考文献：
  名称：

  The SAR of UK-78,282: A novel blocker of human T cell Kv1.3 potassium channels

  摘要：

  UK-78,282 was identified in a human T cell Rb-86 efflux high-throughput screen of our compound libraries. This compound was found to be a potent and selective blacker of human T cell voltage-gated K+ channels and to inhibit T cell activation. The SAR around UK-78,282 and a general pharmacophore hypothesis are presented in this communication. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00163-7

文献信息

• The SAR of UK-78,282: A novel blocker of human T cell Kv1.3 potassium channels
  作者：Laurence E. Burgess、Kevin Koch、Kelvin Cooper、Michael S. Biggers、Mukesh Ramchandani、Jacqueline H. Smitrovich、Eric J. Gilbert、Matthew J. Bruns、Robert J. Mather、Carol B. Donovan、Douglas C. Hanson

  DOI：10.1016/s0960-894x(97)00163-7

  日期：1997.4

  UK-78,282 was identified in a human T cell Rb-86 efflux high-throughput screen of our compound libraries. This compound was found to be a potent and selective blacker of human T cell voltage-gated K+ channels and to inhibit T cell activation. The SAR around UK-78,282 and a general pharmacophore hypothesis are presented in this communication. (C) 1997 Elsevier Science Ltd.