Provided are lincosamide compounds for the treatment of infectious diseases. The lincosamides described herein are modified at the amino acid (southern) region. The lincosamides may have further modification at the C-1 and C-7 positions of the aminooctose (northern) region, thus distinguishing them from lincomycin and clindamycin. Also provided are methods for preparing the lincosamide compounds, pharmaceutical compositions comprising the lincosamide compounds, and methods of treating infectious diseases using the disclosed lincosamide compounds.
本文提供了用于治疗传染病的林可酰胺化合物。本文所述的林可酰胺在
氨基酸(南部)区域进行了修饰。林可酰胺可在
氨基辛糖(北部)区域的 C-1 和 C-7 位进一步修饰,从而使其有别于
林可霉素和
克林霉素。此外,还提供了制备林可酰胺化合物的方法、包含林可酰胺化合物的药物组合物,以及使用所公开的林可酰胺化合物治疗传染性疾病的方法。