3-chloro-7-bromobenzofuran | 1368229-56-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 3-chloro-7-bromobenzofuran
• 英文别名: 7-bromo-3-chlorobenzofuran；7-Bromo-3-chlorobenzofuran；7-bromo-3-chloro-1-benzofuran
• CAS: 1368229-56-4
• 化学式: C₈H₄BrClO
• 分子量: 231.476
• InChiKey: RZFFXIWFRJXFNJ-UHFFFAOYSA-N

物化性质

• 沸点：
  272.4±20.0 °C(Predicted)
• 密度：
  1.721±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-chloro-7-bromobenzofuran 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 N-碘代丁二酰亚胺 、 正丁基锂 、 potassium carbonate 、 caesium carbonate 作用下， 以 甲醇 、 乙二醇二甲醚 、 5,5-dimethyl-1,3-cyclohexadiene 、 乙醚 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 28.0h， 生成
  参考文献：
  名称：

  Discovery of novel tricyclic indole derived inhibitors of HCV NS5B RNA dependent RNA polymerase

  摘要：

  The characterization of HCV genome has identified various vital functional proteins involved in the life cycle of hepatitis C virus. This has resulted in many novel enzymatic targets that are potential for development of therapeutic agents. The HCV RNA dependent RNA polymerase (HCV NS5B) is one such essential enzyme for HCV replication that has been well characterized and studied by various groups to develop novel therapies for hepatitis C. In this paper, we describe our efforts towards the identification and structure-activity relationship (SAR) of novel tricyclic indole derivatives that bind close to the palm site of the NS5B polymerase. X-ray crystal structure of an inhibitor bound to the polymerase is also described. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.01.024
• 作为产物：
  描述：

  1-bromo-2-(2,2-diethoxyethoxy)benzene 在 氯 、 溶剂黄146 作用下， 以 甲苯 为溶剂， 反应 0.83h， 生成 3-chloro-7-bromobenzofuran
  参考文献：
  名称：

  Discovery of novel tricyclic indole derived inhibitors of HCV NS5B RNA dependent RNA polymerase

  摘要：

  The characterization of HCV genome has identified various vital functional proteins involved in the life cycle of hepatitis C virus. This has resulted in many novel enzymatic targets that are potential for development of therapeutic agents. The HCV RNA dependent RNA polymerase (HCV NS5B) is one such essential enzyme for HCV replication that has been well characterized and studied by various groups to develop novel therapies for hepatitis C. In this paper, we describe our efforts towards the identification and structure-activity relationship (SAR) of novel tricyclic indole derivatives that bind close to the palm site of the NS5B polymerase. X-ray crystal structure of an inhibitor bound to the polymerase is also described. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.01.024

文献信息

• 유기전기 소자용 화합물, 이를 이용한 유기전기소자 및 그 전자 장치
  申请人：DUK SAN NEOLUX CO., LTD. 덕산네오룩스 주식회사(120150011099) Corp. No ▼ 161511-0176036BRN ▼312-86-74729

  公开号：KR20200113937A

  公开（公告）日：2020-10-07

  본 발명은 화학식 1로 표시되는 화합물과, 제 1전극, 제 2전극 및 상기 제 1전극과 상기 제 2전극 사이의 유기물층을 포함하는 유기전기소자, 및 상기 유기전기소자를 포함하는 전자장치를 제공한다. 상기 유기물층에 화학식 1로 표시되는 화합물을 포함함으로써, 유기전기소자의 구동전압을 낮출 수 있고 발광 효율 및 수명을 향상시킬 수 있다.

  本发明提供了一种化合物，其化学式表示为1，以及包括第1电极、第2电极和有机物层在第1电极和第2电极之间的有机电子器件，以及包括该有机电子器件的电子装置。通过在所述有机物层中包含化学式为1的化合物，可以降低有机电子器件的驱动电压，提高发光效率和寿命。
• Discovery of novel tricyclic indole derived inhibitors of HCV NS5B RNA dependent RNA polymerase
  作者：Srikanth Venkatraman、Francisco Velazquez、Stephen Gavalas、Wanli Wu、Kevin X. Chen、Anilkumar G. Nair、Frank Bennett、Yuhua Huang、Patrick Pinto、Yueheng Jiang、Oleg Selyutin、Bancha Vibulbhan、Qingbei Zeng、Charles Lesburg、Jose Duca、Hsueh-Cheng Huang、Sony Agrawal、Chuan-kui Jiang、Eric Ferrari、Cheng Li、Joseph Kozlowski、Stuart Rosenblum、Neng-Yang Shih、F. George Njoroge

  DOI：10.1016/j.bmc.2013.01.024

  日期：2013.4

  The characterization of HCV genome has identified various vital functional proteins involved in the life cycle of hepatitis C virus. This has resulted in many novel enzymatic targets that are potential for development of therapeutic agents. The HCV RNA dependent RNA polymerase (HCV NS5B) is one such essential enzyme for HCV replication that has been well characterized and studied by various groups to develop novel therapies for hepatitis C. In this paper, we describe our efforts towards the identification and structure-activity relationship (SAR) of novel tricyclic indole derivatives that bind close to the palm site of the NS5B polymerase. X-ray crystal structure of an inhibitor bound to the polymerase is also described. (C) 2013 Elsevier Ltd. All rights reserved.