2-octyne-1,8-diol | 75315-90-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-octyne-1,8-diol
• 英文别名: Oct-2-yne-1,8-diol
• CAS: 75315-90-1
• 化学式: C₈H₁₄O₂
• 分子量: 142.198
• InChiKey: FUMXBCQNLYBBPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-octyne-1,8-diol 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 5.0h， 以75.4%的产率得到1,8-oct-2-enediol
  参考文献：
  名称：

  Klok, R.; Moehlmann, W. M. M.; Wolf, L. van der, Recueil des Travaux Chimiques des Pays-Bas, 1980, vol. 99, # 4, p. 132 - 137

  摘要：

  DOI：
• 作为产物：
  描述：

  7-((tert-butyldimethylsilyl)oxy)hept-2-yn-1-ol 在 potassium tert-butylate 、 4-甲基苯磺酸吡啶 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 叔丁醇 为溶剂， 反应 5.25h， 生成 2-octyne-1,8-diol
  参考文献：
  名称：

  A New Entry to Oxacycles via Base-Catalyzed Endo Mode Cyclization of Allenyl Sulfoxides and Sulfones

  摘要：

  [GRAPHICS]Treatment of the allenyl sulfoxides and sulfones possessing a proper delta -hydroxy appendage at the C-1 position with potassium tert-butoxide effected endo mode ring closure at the sp-hybridized carbon center of the allenyl moiety to provide the five- to eight-membered oxacycles in high yields.

  DOI：

  10.1021/ol0101842

文献信息

• Hydrogenation Promoter, Hydrogenation Catalyst, and Process for Producing Alkene Compound
  申请人：Hori Junichi

  公开号：US20080033221A1

  公开（公告）日：2008-02-07

  A hydrogenation promoter of the present invention is produced by reacting an alkyne compound or an alkene compound, a palladium compound represented by a general formula Pd(II)X j L k (where L represents a monodentate ligand or a polydendate ligand other than a phosphorus-containing ligand (when two or more Ls are present in the compound, the Ls may be the same or different), X represents an anionic group, j represents a value determined according to the valence of X so that X j has a valence of −2 as a whole, and k represents an integer in the range of 0 to 4), and a base in an organic solvent. Specifically, The hydrogenation promoter of the invention includes palladium nanoparticles containing the alkyne compound or the alkene compound as an agglomeration-preventing agent.

  本发明的氢化促进剂是通过在有机溶剂中反应炔烃化合物或烯烃化合物、由一般式Pd(II)XjLk表示的钯化合物(其中L表示单齿配体或不含磷的多齿配体（当化合物中存在两个或两个以上的L时，L可以相同也可以不同），X表示阴离子基团，j表示根据X的价确定的值，使Xj整体价为-2，k表示0到4之间的整数)，以及碱的反应产生的。具体来说，本发明的氢化促进剂包括含有炔烃化合物或烯烃化合物作为凝聚抑制剂的钯纳米粒子。
• Base-Catalyzed Endo-Mode Cyclization of Allenes:  Easy Preparation of Five- to Nine-Membered Oxacycles
  作者：Chisato Mukai、Masaru Ohta、Haruhisa Yamashita、Shinji Kitagaki

  DOI：10.1021/jo0488614

  日期：2004.10.1

  A reliable and efficient procedure for constructing five- to eight-membered oxacycles has been developed. Allenes with both a phosphoryl group and a suitable delta-hydroxyalkyl side chain at the Cl-position underwent an endo mode ring-closing reaction to give five- to seven-membered oxacycles. Changing the phosphoryl group to a phosphono functionality facilitated the preparation of eight-membered congeners. Introduction of a cis double bond to the alkyl side chain of the starting allenes made possible the easy formation of medium-sized oxacycles, such as the dihydrooxocin and tetrahydrooxonin frameworks, regardless of the electron-withdrawing group (POPh2, PO(OEt)(2), SOPh, and SO2Ph) at the C-1-position.
• KLOK R.; MOEHLMANN W. M. M.; WOLF L.; PABON H. J. J., REC. TRAV. CHIM. PAYS-BAS, 1980, 99, NO 4, 132-137
  作者：KLOK R.、 MOEHLMANN W. M. M.、 WOLF L.、 PABON H. J. J.

  DOI：——

  日期：——
• US7619125B2
  申请人：——

  公开号：US7619125B2

  公开（公告）日：2009-11-17
• A New Entry to Oxacycles via Base-Catalyzed Endo Mode Cyclization of Allenyl Sulfoxides and Sulfones
  作者：Chisato Mukai、Haruhisa Yamashita、Miyoji Hanaoka

  DOI：10.1021/ol0101842

  日期：2001.10.1

  [GRAPHICS]Treatment of the allenyl sulfoxides and sulfones possessing a proper delta -hydroxy appendage at the C-1 position with potassium tert-butoxide effected endo mode ring closure at the sp-hybridized carbon center of the allenyl moiety to provide the five- to eight-membered oxacycles in high yields.