3,6-Diaza-3,6-dimethyl-1,8-octanedicarboxylic acid dimethyl ester | 14511-01-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3,6-Diaza-3,6-dimethyl-1,8-octanedicarboxylic acid dimethyl ester
• 英文别名: N,N'-Dimethyl-N,N'-bis-<2-methoxycarbonyl-ethyl>-ethylendiamin；Methyl 3-[2-[(3-methoxy-3-oxopropyl)-methylamino]ethyl-methylamino]propanoate；methyl 3-[2-[(3-methoxy-3-oxopropyl)-methylamino]ethyl-methylamino]propanoate
• CAS: 14511-01-4
• 化学式: C₁₂H₂₄N₂O₄
• 分子量: 260.334
• InChiKey: ZSSNLXSVEYHXFI-UHFFFAOYSA-N

物化性质

• 沸点：
  114-117 °C(Press: 0.3 Torr)
• 密度：
  1.049±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  18
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  59.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3,6-Diaza-3,6-dimethyl-1,8-octanedicarboxylic acid dimethyl ester 在 甲醇 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 、 sodium hydroxide 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  [EN] IONIZABLE LIPIDS AND COMPOSITIONS FOR NUCLEIC ACID DELIVERY
  [FR] LIPIDES IONISABLES ET COMPOSITIONS POUR L'ADMINISTRATION D'ACIDES NUCLÉIQUES

  摘要：

  The present disclosure relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof, which can be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid.

  公开号：

  WO2022218295A1
• 作为产物：
  描述：

  丙烯酸甲酯（MA） 、 N,N'-二甲基乙二胺 生成 3,6-Diaza-3,6-dimethyl-1,8-octanedicarboxylic acid dimethyl ester
  参考文献：
  名称：

  STRUCTURE OF ADJUSTABLE STERIC HINDRANCE WEAK BASIC LIGHT STABILIZER AND PREPARATION METHOD AND APPLICATION THEREOF

  摘要：

  新化合物和合成方法领域相关，特别是一种结构可调节立体位阻的弱碱光稳定剂及其制备方法和应用。根据这种创新的光稳定剂，通过在氮原子周围引入产生立体位阻的取代基来调节其立体位阻；此外，通过调节极性基团的距离可以影响氮原子的电负性，从而调节氮原子的碱性或亲核性。通过调节氮原子所在位置的立体位阻、亲核性或碱性，可以获得所需的效果，从而扩大创新光稳定剂的应用范围，使其适用于PC、聚酯、PVC等微酸性或某些亲电性聚合材料，作为光稳定保护助剂。

  公开号：

  US20220145045A1

文献信息

• Electrochemical fluorination of several 1,4-bis[(methoxycarbonyl)alkyl] substituted piperazines
  作者：Takashi Abe、Hajime Baba、Irina Soloshonok

  DOI：10.1016/s0022-1139(01)00357-8

  日期：2001.5

  Four piperazines, having bis[(methoxycarbonyl)alkyl] groups (CH2CH2C(O)OMe (1), CH(CH3)C(O)OMe (2), CH2CH(CH3)C(O)OMe (3) and CH(CH3)CH2C(O)OMe (4) at the 1- and 4-positions of the piperazine ring), were subjected to electrochemical fluorination (ECF). Two bis[(methoxycarbonyl)alkyl] derivatives of N,N′-dimethylethylenediamine (molecular formulae: MeO(O)CH2CH2N(CH3)CH2CH2N(CH3)CH2CH2C(O)OMe (5)

  四个哌嗪，具有双[（甲氧基羰基）烷基]基团（CH 2 CH 2 C（O）OME（1），CH（CH 3）C（O）OME（2），CH 2 CH（CH 3）对C（O）OMe（3）和CH（CH 3）CH 2 C（O）OMe（4）在哌嗪环的1和4位进行电化学氟化（ECF）。N，N'-二甲基乙二胺的两个双[（甲氧羰基）烷基]衍生物（分子式：MeO（O）CH 2 CH 2 N（CH 3）CH 2 CH 2 N（CH 3）CH 2 CH 2 C（O）OMe（5）和MeO（O）CH（CH 3）CH 2 N（CH 3）CH 2 CH 2 N（CH 3）CH 2 CH（CH 3）C（O） OMe]（6））也进行了类似的氟化以用于比较研究。上哌嗪衍生物（ECF的1 - 4），[全氟烷基（氟羰基）]形成基团具有双相应perfluoropiperazines，而底物的ECF 5和6仅提供降解的产品。含有全氟哌
• STRUCTURE OF ADJUSTABLE STERIC HINDRANCE WEAK BASIC LIGHT STABILIZER AND PREPARATION METHOD AND APPLICATION THEREOF
  申请人：Shaoxing Ruikang Biotechnologies Co., Inc

  公开号：US20220145045A1

  公开（公告）日：2022-05-12

  The field of new compounds and synthesis methods thereof are related, and particularly to a structure of a steric hindrance adjustable weak base light stabilizer and a preparation method and application thereof. According to the innovative light stabilizer, a steric hindrance thereof is adjusted by establishing substituent generating the steric hindrance around nitrogen atoms; moreover, an electronegativity of the nitrogen atom can be influenced by adjusting a distance of a polar group, so that an alkalinity or a nucleophilicity of the nitrogen atom is adjusted. A desired effect is obtained by adjusting a steric hindrance and a nucleophilic property or an alkalinity where the nitrogen atom is located, so that an application range of the innovative light stabilizer is widened, and the innovative light stabilizer is suitable for PC, polyester, PVC and other slightly acidic or certain electrophilic polymer materials to serve as a light stability protecting aid.

  新化合物和合成方法领域相关，特别是一种结构可调节立体位阻的弱碱光稳定剂及其制备方法和应用。根据这种创新的光稳定剂，通过在氮原子周围引入产生立体位阻的取代基来调节其立体位阻；此外，通过调节极性基团的距离可以影响氮原子的电负性，从而调节氮原子的碱性或亲核性。通过调节氮原子所在位置的立体位阻、亲核性或碱性，可以获得所需的效果，从而扩大创新光稳定剂的应用范围，使其适用于PC、聚酯、PVC等微酸性或某些亲电性聚合材料，作为光稳定保护助剂。
• BIODEGRADABLE POLY (BETA-AMINO ESTERS) AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20160022821A1

  公开（公告）日：2016-01-28

  Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
• US8557231B2
  申请人：——

  公开号：US8557231B2

  公开（公告）日：2013-10-15
• US9101666B2
  申请人：——

  公开号：US9101666B2

  公开（公告）日：2015-08-11