diisopropyl 4-bromophthalate | 1431380-27-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diisopropyl 4-bromophthalate
• 英文别名: Dipropan-2-yl 4-bromobenzene-1,2-dicarboxylate
• CAS: 1431380-27-6
• 化学式: C₁₄H₁₇BrO₄
• 分子量: 329.191
• InChiKey: CTZGVLUQNVSTAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  diisopropyl 4-bromophthalate 在 四氧化锇 、 四(三苯基膦)钯 、 三氯化硼 、 sodium hydride 、 N-甲基吗啉氧化物 、 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 15.67h， 生成 3-(5-(1,2-dihydroxyethyl)-1,3-dioxoisoindolin-2-yl)-3',4'-difluoro[1,1'-biphenyl]-4-carboxylic acid
  参考文献：
  名称：

  [EN] PFKFB3 INHIBITORS AND THEIR USES
  [FR] INHIBITEURS DE PFKFB3 ET LEURS UTILISATIONS

  摘要：

  这项披露涉及新的邻苯二甲酰亚胺和异吲哚酮衍生物以及其他PFKFB3抑制剂，用于治疗疾病。该发明还涉及含有此类PFKFB3抑制剂的药物组合物，其制备方法，作为治疗剂的使用方法，以及用于治疗的药物的制备方法，以及包含此类PFKFB3抑制剂的工具包和其他发明。这些PFKFB3抑制剂对于治疗和预防癌症、神经退行性疾病、自身免疫疾病、炎症性疾病、多发性硬化症、代谢性疾病、抑制血管生成以及其他疾病和情况具有用途，在这些情况下，PFKFB3和/或PFKFB4的调节具有益处，以及神经保护作用。

  公开号：

  WO2020080979A1
• 作为产物：
  描述：

  苯酐 在 氯化亚砜 、 溴 、 sodium hydroxide 作用下， 以 水 为溶剂， 反应 9.0h， 生成 diisopropyl 4-bromophthalate
  参考文献：
  名称：

  聚合邻苯二甲酸酯：潜在的非迁移性高分子增塑剂

  摘要：

  描述了通过Suzuki偶联合成4-乙烯基1,2-邻苯二甲酸酯，然后通过硝基氧介导的聚合反应制备短均聚物（聚合度[DP] = 10–40，多分散指数[PDI] = 1.1–1.3 ）。制备了丙烯酸正丁酯（NBA）的无规共聚物。制备了富含中等长度（DP = 16-48，PDI = 1.2-1.8）和较短长度（DP = 8-17，PDI = 1.2-1.3）的邻苯二甲酸酯残基的共聚物。还制备了富含NBA残留物的共聚物（DP = 13–19，PDI = 1.2–1.3）。所有聚合物均为油性液体，在75至-40°C之间未检测到玻璃化转变温度，表明这些聚合邻苯二甲酸酯有望成为潜在的非迁移性邻苯二甲酸酯增塑剂。©2012 Wiley Periodicals，Inc. J Polym Sci A部分：Polym Chem，2013年

  DOI：

  10.1002/pola.26485

文献信息

• Covalent bonding of <i>N</i>‐hydroxyphthalimide on mesoporous silica for catalytic aerobic oxidation of <i>p‐</i>xylene at atmospheric pressure
  作者：Tomasz Berniak、Piotr Łątka、Marek Drozdek、Anna Rokicińska、Aleksander Jaworski、Antonio Leyva‐Pérez、Piotr Kuśtrowski

  DOI：10.1002/cplu.202300631

  日期：——

  The surface of SBA‐15 mesoporous silica was modified by N‐hydroxyphthalimide (NHPI) moieties acting as immobilized active species for aerobic oxidation of alkylaromatic hydrocarbons. The incorporation was carried out by four original approaches: the grafting‐from and grafting‐onto techniques, using the presence of surface silanols enabling the formation of particularly stable O−Si−C bonds between the silica support and the organic modifier. The strategies involving the Heck coupling led to the formation of NHPI groups separated from the SiO₂ surface by a vinyl linker, while one of the developed modification paths based on the grafting of an appropriate organosilane coupling agent resulted in the active phase devoid of this structural element. The successful course of the synthesis was verified by FTIR and ¹H NMR measurements. Furthermore, the formed materials were examined in terms of their chemical composition (elemental analysis, thermal analysis), structure of surface groups (¹³C NMR, XPS), porosity (low‐temperature N₂ adsorption), and tested as catalysts in the aerobic oxidation of p‐xylene at atmospheric pressure. The highest conversion and selectivity to p‐toluic acid were achieved using the catalyst with enhanced availability of non‐hydrolyzed NHPI groups in the pore system. The catalytic stability of the material was additionally confirmed in several subsequent reaction cycles.

  摘要用 N-羟基邻苯二甲酰亚胺（NHPI）分子修饰 SBA-15 介孔二氧化硅的表面，使其成为烷基芳烃有氧氧化的固定活性物质。采用了四种独创的方法：从接枝和从上接枝技术，利用表面硅烷醇的存在，在二氧化硅支架和有机改性剂之间形成特别稳定的 O-Si-C 键。采用赫克耦合的策略可形成 NHPI 基团，并通过乙烯基连接体与二氧化硅表面分离，而采用接枝适当的有机硅烷耦合剂的改性方法则可使活性相不含这种结构元素。傅立叶变换红外光谱和 1H NMR 测量验证了合成过程的成功。此外，还从化学成分（元素分析、热分析）、表面基团结构（13C NMR、XPS）、孔隙率（低温 N2 吸附）等方面对所形成的材料进行了研究，并将其作为常压下对二甲苯有氧氧化的催化剂进行了测试。使用孔隙体系中非水解 NHPI 基团可用性增强的催化剂，对甲苯酸的转化率和选择性最高。此外，该材料的催化稳定性在随后的几个反应循环中也得到了证实。
• METHOD FOR PRODUCING SOLID CATALYST COMPONENT FOR USE IN POLYMERIZATION OF OLEFIN, CATALYST FOR USE IN POLYMERIZATION OF OLEFIN, AND METHOD FOR PRODUCING OLEFIN POLYMER
  申请人：Toho Titanium CO., LTD.

  公开号：EP2876118A1

  公开（公告）日：2015-05-27

  A method for producing a solid catalyst component for olefin polymerization produces a novel solid catalyst component for olefin polymerization that achieves excellent olefin polymerization activity and activity with respect to hydrogen during polymerization, and can produce an olefin polymer that exhibits a high MFR, high stereoregularity, and excellent rigidity. The method includes a first step that brings a magnesium compound, a tetravalent titanium halide compound, and one or more first internal electron donor compounds selected from specific aromatic dicarboxylic diesters into contact with each other to effect a reaction, followed by washing, a second step that brings a tetravalent titanium halide compound and one or more second internal electron donor compounds into contact with a product obtained by the first step to effect a reaction, followed by washing, and a third step that brings one or more third internal electron donor compounds into contact with a product obtained by the second step to effect a reaction.

  一种生产烯烃聚合用固体催化剂组分的方法可生产出一种新型的烯烃聚合用固体催化剂组分，该组分具有优异的烯烃聚合活性和聚合过程中对氢的活性，并可生产出具有高MFR、高立体规整度和优异刚性的烯烃聚合物。该方法包括第一步，使镁化合物、四价卤化钛化合物和一种或多种选自特定芳香族二羧酸二酯的第一内部电子供体化合物相互接触以发生反应，然后进行洗涤、第二步：使四价卤化钛化合物和一种或多种第二内部电子供体化合物与第一步得到的产物接触，以发生反应，然后进行洗涤；第三步：使一种或多种第三内部电子供体化合物与第二步得到的产物接触，以发生反应。
• PRODUCTION METHOD FOR SOLID CATALYST COMPONENT FOR POLYMERIZING OLEFINS, CATALYST FOR POLYMERIZING OLEFINS, AND PRODUCTION METHOD FOR POLYMERIZED OLEFINS
  申请人：TOHO TITANIUM CO., LTD.

  公开号：EP2963063A1

  公开（公告）日：2016-01-06

  A method for producing a solid catalyst component for olefin polymerization produces a novel solid catalyst component for olefin polymerization that achieves excellent olefin polymerization activity and activity with respect to hydrogen during polymerization, and can produce an olefin polymer that exhibits a high MFR, high stereoregularity, and excellent rigidity. The method includes a first step that brings a magnesium compound, a tetravalent titanium halide compound, and one or more first internal electron donor compounds excluding an aromatic dicarboxylic acid diester into contact with each other to effect a reaction, followed by washing; a second step that brings a tetravalent titanium halide compound and one or more second internal electron donor compounds into contact with a product obtained by the first step to effect a reaction, followed by washing; and a third step that brings one or more third internal electron donor compounds into contact with a product obtained by the second step to effect a reaction.

  一种生产烯烃聚合用固体催化剂组分的方法可生产出一种新型的烯烃聚合用固体催化剂组分，该组分具有优异的烯烃聚合活性和聚合过程中对氢的活性，并可生产出具有高MFR、高立体规整度和优异刚性的烯烃聚合物。该方法包括第一步，使镁化合物、四价卤化钛化合物和一种或多种第一内部电子供体化合物（不包括芳香族二羧酸二酯）相互接触以发生反应，然后进行洗涤；第二步，使四价卤化钛化合物和一种或多种第二内部电子供体化合物与第一步得到的产物接触，以发生反应，然后进行洗涤；以及第三步，使一种或多种第三内部电子供体化合物与第二步得到的产物接触，以发生反应。
• SOLID CATALYST COMPONENT FOR POLYMERIZING OLEFINS, CATALYST FOR POLYMERIZING OLEFINS, AND PRODUCTION METHOD FOR POLYMERIZED OLEFINS
  申请人：Toho Titanium Co., Ltd.

  公开号：EP2963062A1

  公开（公告）日：2016-01-06

  A solid catalyst component for olefin polymerization includes titanium, magnesium, a halogen, a compound represented by (R1)kC6H4-k(COOR2)(COOR3), and a compound represented by R4O-C(=O)-O-Z-OR5. The solid catalyst component is a novel solid catalyst component for olefin polymerization that achieves excellent olefin polymerization activity and activity with respect to hydrogen during polymerization, and can produce an olefin polymer that exhibits a high MFR, high stereoregularity, and excellent rigidity.

  一种用于烯烃聚合的固体催化剂组分包括钛、镁、卤素、由(R1)kC6H4-k(COOR2)(COOR3)代表的化合物和由R4O-C(=O)-O-Z-OR5代表的化合物。该固体催化剂组分是一种用于烯烃聚合的新型固体催化剂组分，可在聚合过程中获得优异的烯烃聚合活性和相对于氢的活性，并可生产出具有高 MFR、高立体规整度和优异刚性的烯烃聚合物。
• CATALYST FOR OLEFIN POLYMERIZATION, METHOD FOR PRODUCING OLEFIN POLYMER, AND PROPYLENE/ -OLEFIN COPOLYMER
  申请人：Toho Titanium Co., Ltd.

  公开号：EP3623393A1

  公开（公告）日：2020-03-18

  Provided is a catalyst for polymerization of an olefin which can prepare, with high productivity, a polymer having excellent hydrogen activity and high stereoregularity and MFR even in homopolymerization at a high temperature, and is also capable of producing a copolymer that achieves excellent hydrogen activity and copolymerization activity even in copolymerization at a high temperature and is excellent in impact resistance. The present invention provides a catalyst for polymerization of an olefin, comprising a compound represented by the general formula R1R2Si(NHR3)2 wherein R1 is a cycloalkyl group having 3 to 12 carbon atoms or an aromatic hydrocarbon group having 6 to 12 carbon atoms; R2 is a linear alkyl group having 1 to 10 carbon atoms or a branched alkyl group having 3 to 10 carbon atoms; the number of carbon atoms of R1 is larger by 2 or more than that of R2; and R3 is a linear alkyl group having 2 to 6 carbon atoms, a branched alkyl group having 3 to 6 carbon atoms or a cycloalkyl group having 3 to 6 carbon atoms, as an external electron-donating compound.

  本发明提供了一种用于烯烃聚合的催化剂，它能以高生产率制备即使在高温下均聚时也具有优异氢活性和高立体规整度及MFR的聚合物，还能制备即使在高温下共聚时也具有优异氢活性和共聚活性以及优异抗冲击性的共聚物。本发明提供了一种用于烯烃聚合的催化剂，包括通式 R1R2Si(NHR3)2 所代表的化合物 其中 R1 是具有 3 至 12 个碳原子的环烷基或具有 6 至 12 个碳原子的芳香烃基；R2 是具有 1 至 10 个碳原子的直链烷基或具有 3 至 10 个碳原子的支链烷基；R1 的碳原子数比 R2 的碳原子数多 2 个或 2 个以上；以及 R3 是具有 2 至 6 个碳原子的直链烷基、具有 3 至 6 个碳原子的支链烷基或具有 3 至 6 个碳原子的环烷基，作为外部电子供体化合物。