ethyl 2-(2-amino-4-oxazolyl)-2-methoxyimino-acetate | 86312-71-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: ethyl 2-(2-amino-4-oxazolyl)-2-methoxyimino-acetate
• 英文别名: ethyl 2-[2-aminooxazol-4-yl]-2-Z-methoximinoacetate；ethyl 2-(2-aminooxazol-4-yl)-2-methoxyiminoacetate；ethyl (2Z)-2-(2-amino-1,3-oxazol-4-yl)-2-methoxyiminoacetate
• CAS: 86312-71-2
• 化学式: C₈H₁₁N₃O₄
• 分子量: 213.193
• InChiKey: BARYHMCDDRYGMN-WDZFZDKYSA-N

物化性质

• 熔点：
  148-149 °C(Solv: isopropyl ether (108-20-3))
• 沸点：
  340.9±52.0 °C(Predicted)
• 密度：
  1.38±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  99.9
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  ethyl 2-(2-amino-4-oxazolyl)-2-methoxyimino-acetate 生成 (2Z)-2-(2-amino-1,3-oxazol-4-yl)-2-methoxyiminoacetic acid
  参考文献：
  名称：

  FURLENMEIER, A.;HOFHEINZ, W.;HUBSCHWERLEN, C. N.;ISENRING, H. P.

  摘要：

  DOI：
• 作为产物：
  描述：

  (Z)-γ-bromo-β-oxo-α-methoxyiminobutyric acid ethyl ester 生成 ethyl 2-(2-amino-4-oxazolyl)-2-methoxyimino-acetate
  参考文献：
  名称：

  FURLENMEIER, A.;HOFHEINZ, W.;HUBSCHWERLEN, C. N.;ISENRING, H. P.

  摘要：

  DOI：

文献信息

• Oxazole and oxadiazole cephalosporins
  申请人：Eli Lilly and Company

  公开号：US04406898A1

  公开（公告）日：1983-09-27

  Broad spectrum cephalosporin antibiotics represented by the betaine structure of the formula ##STR1## wherein R is a 5-membered amino-substituted heterocyclic containing oxygen and nitrogen; R' is e.g., hydrogen or C.sub.1 -C.sub.4 alkyl; and bicyclicpyridinium is a thienopyridinium or a furopyridinium group; are prepared by reacting a silylated 3-iodomethyl cephalosporin with a thienopyridine, e.g., thieno[2,3-b]pyridine or a furopyridine. The compounds are potent antibacterials against gram-positive and gram-negative organisms. Pharmaceutical compositions and a method for treating bacterial infections are also provided.

  广谱头孢菌素抗生素，以公式##STR1##中的甜菜碱结构代表，其中R是含氧和氮的5-成员氨基取代杂环；R'是例如，氢或C.sub.1 -C.sub.4烷基；并且双环吡啶是一种噻吡啉或呋吡啉基团；通过将硅烷化的3-碘甲基头孢菌素与噻吡啉（例如，噻吡[2,3-b]吡啶或呋吡啉）反应制备。这些化合物对革兰氏阳性和阴性细菌有很强的抗菌作用。还提供了用于治疗细菌感染的药物组合物和方法。
• Oximino-substituted cephalosporin compounds
  申请人：Eli Lilly and Company

  公开号：US04379787A1

  公开（公告）日：1983-04-12

  Broad spectrum cephalosporin antibiotics represented by the formula ##STR1## wherein R is an amino-substituted oxazole, oxadiazol, or isoxazole heterocyclic, R' is C.sub.1 -C.sub.4 alkyl, a carboxysubstituted alkyl or cycloalkyl group, etc., and .sup..sym. R.sub.1 is an oximino-substituted pyridinium, quinolinium or isoquinolinium group, e.g., .sup..sym. R.sub.1 is a 3- or 4-formylpyridinium oxime group; pharmaceutical compositions comprising the antibiotic, and a method for treating antibacterial infections are provided.

  广谱头孢菌素抗生素的化学式为##STR1##，其中R是氨基取代的噁唑、噻二唑或异噁唑杂环，R'是C.sub.1 -C.sub.4烷基、羧基取代的烷基或环烷基等，.sup..sym. R.sub.1是氧亚胺取代的吡啶、喹啉或异喹啉基团，例如，.sup..sym. R.sub.1是3-或4-甲醛基吡啶氧肟基团；提供了包含该抗生素的药物组合物，以及治疗抗菌感染的方法。
• 3'-Substituted quinolinium cephalosporins
  申请人：Eli Lilly and Company

  公开号：US04382931A1

  公开（公告）日：1983-05-10

  Broad spectrum cephalosporin antibiotics represented by the formula ##STR1## are provided. In the formula, R represents a 2-aminooxazol-4-yl, 5-amino-1,2,4-oxadiazol-3-yl, or 5-aminoisoxazol-3-yl heterocyclic group; R' is hydrogen, C.sub.1 -C.sub.4 alkyl, a carboxy-substituted alkyl or cycloalkyl group or a C.sub.1 -C.sub.4 alkyl ester or carboxy-protecting ester derivative thereof; or an N-substituted carbamoyl group; and R.sub.1 and R.sub.2 are independently hydrogen or a substituent group, eg. halo, hydroxy, amino, carbamoyl, alkyl, or trifluoromethyl. The antibiotics are useful in a method for treating bacterial infections and can be formulated into pharmaceutical formulations for such use.

  提供了以##STR1##表示的广谱头孢菌素抗生素。在公式中，R代表2-氨基噁唑-4-基，5-氨基-1,2,4-噁二唑-3-基，或5-氨基异噁唑-3-基杂环基团；R'是氢，C.sub.1 -C.sub.4烷基，羧基取代的烷基或环烷基团，或C.sub.1 -C.sub.4烷基酯或羧基保护酯衍生物；或N-取代的氨基甲酰基团；而R.sub.1和R.sub.2独立地是氢或取代基团，例如，卤素，羟基，氨基，氨基甲酰基，烷基，或三氟甲基。这些抗生素可用于治疗细菌感染的方法，并可制成用于此类用途的药物制剂。
• 7-[2-(2-Aminooxazol-4-yl)-2-(oximino)acetamido]cephalosporin antibiotics
  申请人：Eli Lilly and Company

  公开号：US04430499A1

  公开（公告）日：1984-02-07

  Cephalosporin broad spectrum antibiotics possessing a 7.beta.-[2-[(2-aminooxazol)-4-yl]-2-(substituted oximino)acetamido side chain and a variety of substituents at the 3-position of the cephalosporins are claimed. Also claimed are intermediates in the synthesis of the above cephalosporin antibiotics.

  声明了具有7.beta.-[2-[(2-氨基噁唑)-4-基]-2-(取代氧肟基)乙酰胺侧链和在头孢菌素的3-位置具有多种取代基的头孢菌素广谱抗生素。此外，还声明了上述头孢菌素抗生素的合成中间体。
• WHEELER, W. J.
  作者：WHEELER, W. J.

  DOI：——

  日期：——