N-allylpropionamide | 60205-24-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-allylpropionamide
• 英文别名: N-prop-2-enylpropanamide
• CAS: 60205-24-5
• 化学式: C₆H₁₁NO
• mdl: MFCD03392923
• 分子量: 113.159
• InChiKey: JVVWOKSULSIVFP-UHFFFAOYSA-N

物化性质

• 沸点：
  105-106 °C(Press: 8 Torr)
• 密度：
  0.879±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-allylpropionamide 在 盐酸 、 红铝 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 甲苯 为溶剂， 反应 43.0h， 生成 N-n-propylallylamine hydrochloride
  参考文献：
  名称：

  An efficient sequence for the preparation of small secondary amine hydrochloride salts for focused library generation without need for distillation or chromatographic purification

  摘要：

  Collections of small secondary amines for compound library generation can be efficiently prepared by amide reduction using BH(3)-THF or Red-Al followed by brief methanolysis, trapping with di-tert-butyl dicarbonate, and deprotection with 4M HCl in dioxane. The sequence requires no chromatography or distillation and provides multi-gram quantities of pure HCl salts in a short time.

  DOI：

  10.1016/j.bmcl.2004.04.014
• 作为产物：
  描述：

  丙烯胺 、 丙腈 在 Iron(III) nitrate nonahydrate 作用下， 反应 24.0h， 以100%的产率得到N-allylpropionamide
  参考文献：
  名称：

  An iron-catalysed synthesis of amides from nitriles and amines

  摘要：

  The cheap, commercially available iron complex, Fe(NO3)(3)center dot 9H(2)O, has been used to catalyse the formation of amides by the addition of amines to nitriles. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.05.021

文献信息

• Photochemistry of Epoxynaphthoquinones. 8. Endo-Stereoselective Photocycloaddition of 2,3-Epoxy-2,3-dihydro-2,3-dimethyl-1,4-naphthoquinone to Olefins Containing Amide Group
  作者：Kazuhiro Maruyama、Atsuhiro Osuka、Katsuhiko Nakagawa

  DOI：10.1246/bcsj.60.1021

  日期：1987.3

  Irradiation of a benzene solution of 2,3-epoxy-2,3-dihydro-2,3-dimethyl-1,4-naphthoquinone with olefins containing amide group, i.e., N-substituted acrylamides and N-allylcarboxamides predominantly gave the endo-cycloadducts. Upon further irradiation, the cycloadducts underwent photorearrangement to give spirophthalides and alkylidenephthalides.

  苯溶液中2,3-环氧-2,3-二氢-2,3-二甲基-1,4-萘醌与含有酰胺基的烯烃，即N-取代丙烯酰胺和N-烯丙基羧酰胺的照射主要生成endo-环加成物。进一步照射后，这些环加成物发生光重排，生成螺苯并二氢吡喃酮和烷叉基苯并二氢吡喃酮。
• INHIBITORS OF UDP-GALACTOPYRANOSE MUTASE
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：US20170258805A1

  公开（公告）日：2017-09-14

  Compounds and salts thereof which are acyl-sulfonamides or certain carboxylic acids and which inhibit microbial growth or attenuate the virulence of pathogenic microorganisms and which inhibit UDP-galactopyranose mutase (UGM). Compounds of the invention include 2-aminothiazoles and triazolothiadiazines, particularly 3,6,7-substituted-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines, and 2-amino and salts thereof. Methods for inhibiting growth or attenuating virulence of microbial pathogens including mycobacterium , for example, M. tuberculosis and M. smegmatis and Klebsiella , for example, Klebsiella pneumoniae . Methods for inhibiting eukaryotic human and animal pathogens, and fungi and nematodes in particular. Methods for treatment of infections by prokaryotic and eukaryotic pathogens employing compounds of the invention.

  其酰基磺酰胺或某些羧酸的化合物及其盐，能够抑制微生物生长或减弱病原微生物的毒力，并且能够抑制UDP-半乳糖吡喃糖异构酶（UGM）。该发明的化合物包括2-氨基噻唑和三唑噻二嗪，特别是3,6,7-取代的7H-[1,2,4]三唑噻二嗪和其盐，以及2-氨基。抑制微生物病原体生长或减弱其毒力的方法包括结核分枝杆菌（例如结核分枝杆菌和平滑分枝杆菌）和克雷伯氏菌（例如肺炎克雷伯氏菌）等微生物病原体。抑制真核人类和动物病原体、真菌和线虫的方法，特别是治疗原核和真核病原体感染的方法，采用了该发明的化合物。
• COMPOUNDS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASE
  申请人：SHY Therapeutics LLC

  公开号：US20170174699A1

  公开（公告）日：2017-06-22

  Provided herein are compounds that inhibit the phosphorylation of MAPK and thus are useful in compositions and methods for treating cancer and inflammatory disease.

  本文提供了抑制MAPK磷酸化的化合物，因此可用于治疗癌症和炎症性疾病的组合物和方法。
• Nickel-Catalyzed Synthesis of Enamides and Enecarbamates<i>via</i>Isomerization of Allylamides and Allylcarbamates
  作者：Juliette Halli、Philipp Kramer、Maren Bechthold、Georg Manolikakes

  DOI：10.1002/adsc.201500461

  日期：2015.10.12

  A single-component, air-stable nickel precatalyst can catalyze the isomerization of allylamides for the synthesis of enamides. The scope of the reaction encompasses various substituted allylamides and allylcarbamates as well as homoallylamides. The reaction can be performed on a multigram-scale without specialized glove-box equipment or Schlenk techniques.

  单组分，空气稳定的镍预催化剂可催化烯丙基酰胺的异构化反应，以合成烯酰胺。反应范围包括各种取代的烯丙基酰胺和烯丙基氨基甲酸酯以及均烯丙基。该反应无需专门的手套箱设备或Schlenk技术即可在数克范围内进行。
• [EN] CARBONYL CONTAINING COMPOUNDS FOR CONTROLLING AND REPELLING CIMICIDAE POPULATIONS<br/>[FR] COMPOSÉS CONTENANT UN CARBONYLE POUR MAÎTRISER ET REPOUSSER DES POPULATIONS DE CIMICIDAE
  申请人：SEMIOSBIO TECHNOLOGIES INC

  公开号：WO2012129702A1

  公开（公告）日：2012-10-04

  Compositions and methods for controlling and/or repelling bedbugs are provided. The compositions comprise one or more compounds having bedbug repellant activity. Such compounds may be, for example, naturally occurring semiochemicals or structural or functional analogs of naturally occurring semiochemicals. Exemplary compounds are compounds of general formula (I).

  提供用于控制和/或驱避臭虫的组合物和方法。这些组合物包括具有驱避臭虫活性的一个或多个化合物。这些化合物可能是自然发生的信息素或自然发生的信息素的结构或功能类似物，例如通式(I)的化合物。