2,3-dihydro-1,3-dimethyl-2-methylene-3-phenyl-1H-indole | 51167-76-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2,3-dihydro-1,3-dimethyl-2-methylene-3-phenyl-1H-indole
• 英文别名: 1,3-dimethyl-2-methylene-3-phenyl-2,3-dihydro-indole；1,3-dimethyl-2-methylene-3-phenyl-indoline；1,3-Dimethyl-2-methylen-3-phenyl-indolin；1,3-Dimethyl-2-methylene-3-phenylindoline；1,3-dimethyl-2-methylidene-3-phenylindole
• CAS: 51167-76-1
• 化学式: C₁₇H₁₇N
• 分子量: 235.329
• InChiKey: BJOQPEPHPPTNRF-UHFFFAOYSA-N

物化性质

• 沸点：
  335.5±42.0 °C(Predicted)
• 密度：
  1.09±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,3-dihydro-1,3-dimethyl-2-methylene-3-phenyl-1H-indole 在 盐酸 、 tin 作用下， 生成 1,2,3-trimethyl-3-phenyl-indoline
  参考文献：
  名称：

  Plancher, Gazzetta Chimica Italiana, 1898, vol. 28 II, p. 413

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 alkali 作用下， 生成 2,3-dihydro-1,3-dimethyl-2-methylene-3-phenyl-1H-indole
  参考文献：
  名称：

  Plancher, Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1900, vol. <5> 9 I, p. 119

  摘要：

  DOI：

文献信息

• Synth�se et propri�t�s photochromiques de 1, 3-dihydrospiro[2H-indole-2,3?-[3H]pyrimido[5,4-f][1,4]benzoxazines] et de 1,3-dihydrospiro[2H-indole-2,7?-[7H]thiazolo[5,4-f][1,4]benzoxazines]
  作者：Pascale Tardieu、Roger Dubest、Jean Aubard、Arlette Kellmann、Francis Tfibel、Andr� Samat、Robert Gugliemetti

  DOI：10.1002/hlca.19920750419

  日期：1992.6.24

  Synthesis and Photochrmic Characteristics of 1,3-Dihydrospiro[2H-indole-2,3′-[3H-]pyrimido[5,4-f][1,4]benzoxazines] and 1,3-Dihydrospiro[2H-indole-2,7′[7H]thiazolo[5,4-f][1,4]benzoxazines]

  的合成和特性Photochrmic 1,3-二氢螺[2H-吲哚-2,3' - [3H-]嘧啶并[5,4-f]的[1,4]苯并恶嗪]和1,3-二氢螺[2 ħ -吲哚-2,7'[7 H ]噻唑洛[5,4- f ] [1,4]苯并恶嗪]
• Styryl-substituted spirochromenes of the indoline series
  作者：E. V. Braude、M. A. Gal'bershtam

  DOI：10.1007/bf00480363

  日期：1979.2
• On the reactivity of some 2-methyleneindolines with β-nitroenamines, α-nitroalkenes, and 1,2-diaza-1,3-butadienes
  作者：Orazio A. Attanasi、Gianfranco Favi、Paolino Filippone、Cristina Forzato、Gianluca Giorgi、Stefano Morganti、Patrizia Nitti、Giuliana Pitacco、Egon Rizzato、Domenico Spinelli、Ennio Valentin

  DOI：10.1016/j.tet.2006.04.027

  日期：2006.6

  A study of the behaviour of some electron-rich 2-methyleneindolines (1-3) with different electron-poor reagents (formation of new carbon-carbon and nitrogen-carbon bonds) has furnished interesting results from both synthetic and the mechanistic viewpoints. Enamines 1-3 have been reacted with the beta-nitroenamines 4-7 (reaction CeCl3 center dot 7H(2)O promoted), giving the polymethine dyes 14-23. The same bases 1-3 have been nitroalkylated with the nitroolefins 8-10, furnishing the indolines 24-32, and the diastereoselectivity of the reaction has been thoroughly investigated. The most unexpected results derived from the first example of reaction of Fischer's bases with 1,2-diaza-1,3-butadienes. In fact, with 11-13, the 'unknown' indoline spirodihydropyrroles 33-40 were formed. Their structures were unambiguously assigned, and we determined, as an example, that of 33 by X-ray analysis. (c) 2006 Elsevier Ltd. All rights reserved.
• Plancher, Gazzetta Chimica Italiana, 1898, vol. 28, p. II; 36
  作者：Plancher

  DOI：——

  日期：——
• Plancher, Gazzetta Chimica Italiana, 1898, vol. 28 II, p. 397
  作者：Plancher

  DOI：——

  日期：——