9,9-dimethyl-2,7-dinitro-9H-fluorene | 28320-58-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 9,9-dimethyl-2,7-dinitro-9H-fluorene
• 英文别名: 9,9-dimethyl-2,7-dinitrofluorene
• CAS: 28320-58-3
• 化学式: C₁₅H₁₂N₂O₄
• 分子量: 284.271
• InChiKey: CBSLXBIBKABAGC-UHFFFAOYSA-N

物化性质

• 沸点：
  442.6±38.0 °C(Predicted)
• 密度：
  1.350±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  91.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  9,9-dimethyl-2,7-dinitro-9H-fluorene 在 iron(II,III) oxide 、 一水合肼 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 三氟乙酸 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 生成
  参考文献：
  名称：

  Novel benzidine and diaminofluorene prolinamide derivatives as potent hepatitis C virus NS5A inhibitors

  摘要：

  Our study describes the discovery of a series of highly potent hepatitis C virus (HCV) NS5A inhibitors based on symmetrical prolinamide derivatives of benzidine and diaminofluorene. Through modification of benzidine, L-proline, and diaminofluorene derivatives, we developed novel inhibitor structures, which allowed us to establish a library of potent HCV NS5A inhibitors. After optimizing the benzidine prolinamide backbone, we identified inhibitors embedding meta-substituted benzidine core structures that exhibited the most potent anti-HCV activities. Furthermore, through a battery of studies including hERG ligand binding assay, CYP450 binding assay, rat plasma stability test, human liver microsomal stability test, and pharmacokinetic studies, the identified compounds 24, 26, 27, 42, and 43 are found to be nontoxic, and are expected to be effective therapeutic anti-HCV agents. (C) 2015 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2015.06.033
• 作为产物：
  描述：

  9,9-二甲基芴 在 copper(II) nitrate trihydrate 、 三氟乙酸酐 作用下， 以 氯仿 为溶剂， 以80 %的产率得到9,9-dimethyl-2,7-dinitro-9H-fluorene
  参考文献：
  名称：

  温和条件下螺二芴硝化的区域选择性控制：解释 Crivello 试剂机制

  摘要：

  通过在 Menke 和 Crivello 的条件下操作，首次报道了 9,9'-螺二芴在温和条件下的区域选择性硝化。优化的方案允许以 79% 和 95% 的产率获得 2-硝基和 2,2'-二硝基-9,9'-螺二芴，并且首次获得 2,2',7-三硝基-9,9'-螺二芴，产率为 66%。此外，Crivello 协议中二硝酸盐的作用现已得到阐明，这为功能材料的制备开辟了新的场景。

  DOI：

  10.1021/acs.joc.2c02596

文献信息

• 一种含芴二胺单体、聚酰亚胺薄膜及其制备方法和用途
  申请人：宁波博雅聚力新材料科技有限公司

  公开号：CN112778140B

  公开（公告）日：2023-01-03

  本发明涉及有机光电高分子技术领域，具体涉及一种含芴二胺单体、聚酰亚胺薄膜及其制备方法和用途。本发明提供的含芴二胺单体，具有如式Ⅰ所示的结构，本发明提供的含芴二胺单体与二酐单体聚合可大大提高聚酰亚胺薄膜的耐热性以及降低薄膜的热膨胀系数。
• BENZIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING BENZIDINE DERIVATIVE FOR TREATING LIVER DISEASE CAUSED BY HEPATITIS C VIRUS
  申请人：SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

  公开号：US20160031810A1

  公开（公告）日：2016-02-04

  The disclosed compounds have antiviral activity against C-type virus, an optical isomer thereof, a pharmaceutically acceptable salt thereof, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating liver disease caused by hepatitis C virus. The benzidine derivative according to the present invention has excellent antiviral activity against hepatitis C virus and exhibits excellent medicinal activity in the living body, and thus the pharmaceutical composition containing the same as an active ingredient can be useful as a pharmaceutical composition for preventing or treating liver disease, such as acute hepatitis C, chronic hepatitis C, cirrhosis, or hepatocellular carcinoma, caused by C-type virus.

  揭示的化合物对C型病毒具有抗病毒活性，包括其光学异构体、药学上可接受的盐、制备方法以及含有其作为活性成分的药物组合物，用于预防或治疗由丙型肝炎病毒引起的肝病。根据本发明的苯胺衍生物对丙型肝炎病毒具有出色的抗病毒活性，在活体内表现出优秀的药用活性，因此含有其作为活性成分的药物组合物可作为用于预防或治疗由C型病毒引起的肝病，如急性丙型肝炎、慢性丙型肝炎、肝硬化或肝细胞癌等的药物组合物。
• Extended conjugation in di- and tri-arylmethanes. Part I. Electronic absorption spectra of 9,9-dimethylfluorene analogues of Crystal Violet and Malachite Green
  作者：G. Hallas、J. D. Hepworth、D. R. Waring

  DOI：10.1039/j29700000975

  日期：——

  9,9-Dimethylfluorene analogues of some basic triphenylmethane dyes have been prepared and their absorption spectra have been determined. The extended quinonoid system in 9,9-dimethylfluorene is more energetically favoured than that in biphenyl, but in these dyes the mesomeric effect is not readily transmitted through the fluorenyl system.

  制备了一些碱性三苯甲烷染料的9,9-二甲基芴类似物，并确定了它们的吸收光谱。在能量上，与联苯相比，在9,9-二甲基芴中扩展的醌类体系更受能量青睐，但在这些染料中，介晶效应不易通过芴基体系传递。
• US9598362B2
  申请人：——

  公开号：US9598362B2

  公开（公告）日：2017-03-21
• [EN] NOVEL COMPOUNDS FOR ORGANIC ELECTRONIC MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME<br/>[FR] NOUVEAUX COMPOSÉS POUR UN MATÉRIAU ÉLECTRONIQUE ORGANIQUE ET DISPOSITIF ÉLECTROLUMINESCENT ORGANIQUE UTILISANT LE MÊME
  申请人：ROHM & HAAS ELECT MAT

  公开号：WO2011126225A1

  公开（公告）日：2011-10-13

  Provided are novel compounds for organic electronic material and an organic electroluminescent device using the same. Since the compound for organic electric material exhibits excellent electron transport efficiency, it may prevent crystallization during the production of devices. Further, since it provides good layer formation, it may improve electrical current property of devices. Therefore, it may be used to manufacture OLED devices having reduced driving voltage and improved power efficiency.