2-tert-butyl 1-methyl 1-(1-(methoxycarbonyl)-2-oxocyclopentyl)hydrazine-1,2-dicarboxylate | 1223105-83-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-tert-butyl 1-methyl 1-(1-(methoxycarbonyl)-2-oxocyclopentyl)hydrazine-1,2-dicarboxylate
• 英文别名: Methyl 1-[methoxycarbonyl-[(2-methylpropan-2-yl)oxycarbonylamino]amino]-2-oxocyclopentane-1-carboxylate；methyl 1-[methoxycarbonyl-[(2-methylpropan-2-yl)oxycarbonylamino]amino]-2-oxocyclopentane-1-carboxylate
• CAS: 1223105-83-6
• 化学式: C₁₄H₂₂N₂O₇
• 分子量: 330.338
• InChiKey: SDNIYIWUMIFPCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  111
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  tert-butyl methyl azodicarboxylate 、 2-甲氧羰基环戊酮 在 potassium acetate 作用下， 以 二氯甲烷 为溶剂， 反应 20.0h， 生成 1-tert-butyl 2-methyl 1-(1-(methoxycarbonyl)-2-oxocyclopentyl)hydrazine-1,2-dicarboxylate 、 2-tert-butyl 1-methyl 1-(1-(methoxycarbonyl)-2-oxocyclopentyl)hydrazine-1,2-dicarboxylate
  参考文献：
  名称：

  Enantioselective α-Amination of 1,3-Dicarbonyl Compounds Using Squaramide Derivatives as Hydrogen Bonding Catalysts

  摘要：

  Catalytic enantioselective alpha-hydrazination of 1,3-dicarbonyl compounds with azodicarboxylates was investigated in the presence of our newly developed hydrogen bonding catalyst, squaramide 3j. High yields and high enantioselectivities were achieved with low catalyst loading under mild conditions.

  DOI：

  10.1021/ol1005104

文献信息

• Enantioselective α-Amination of 1,3-Dicarbonyl Compounds Using Squaramide Derivatives as Hydrogen Bonding Catalysts
  作者：Hideyuki Konishi、Tin Yiu Lam、Jeremiah P. Malerich、Viresh H. Rawal

  DOI：10.1021/ol1005104

  日期：2010.5.7

  Catalytic enantioselective alpha-hydrazination of 1,3-dicarbonyl compounds with azodicarboxylates was investigated in the presence of our newly developed hydrogen bonding catalyst, squaramide 3j. High yields and high enantioselectivities were achieved with low catalyst loading under mild conditions.