3-Chloropropyl Phenyl Sulfoxide | 13033-58-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Chloropropyl Phenyl Sulfoxide
• 英文别名: 3-Chloropropylsulfinylbenzene
• CAS: 13033-58-4
• 化学式: C₉H₁₁ClOS
• 分子量: 202.705
• InChiKey: DNSDXNMSCUUVTC-UHFFFAOYSA-N

物化性质

• 沸点：
  350.3±25.0 °C(Predicted)
• 密度：
  1.25±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  36.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-Chloropropyl Phenyl Sulfoxide 在 potassium triiodide 、 硫酸 、 sodium trithiocarbonate 作用下， 以 乙醇 为溶剂， 反应 2.5h， 生成 1,10-Diphenyl-1,5,6,10-tetrathiadecane
  参考文献：
  名称：

  Organic disulfides and related substances. 43. Properties of a mercaptoalkyl sulfoxide, a novel class of structure

  摘要：

  DOI：

  10.1021/jo00326a034
• 作为产物：
  描述：

  苯硫酚锂 在 间氯过氧苯甲酸 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 26.0h， 生成 3-Chloropropyl Phenyl Sulfoxide
  参考文献：
  名称：

  .ALPHA.-Fluorination of Methyl Phenyl Sulfoxide and Related Compounds by Molecular Fluorine: A Novel Method for the Introduction of Fluorine into Sulfoxides Bearing .ALPHA.-H Atoms.

  摘要：

  据报道，通过与分子氟（5% F2/N2）反应，仅直接从含有α-H原子的亚砜生成α-氟磺醚，为此α-氟化反应提出了一种新型非Pummerer型机理。

  DOI：

  10.1248/cpb.44.703

文献信息

• Substituted anilinic piperidines as MCH selective antagonists
  申请人：Marzabadi R. Mohammad

  公开号：US20070043080A1

  公开（公告）日：2007-02-22

  This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier.

  本发明涉及选择性拮抗黑色素浓集激素-1（MCH1）受体的化合物。本发明提供了一种药物组合物，包括本发明化合物的治疗有效量和药学上可接受的载体。本发明提供了一种由本发明化合物的治疗有效量和药学上可接受的载体组成的药物组合物。本发明还提供了一种制备药物组合物的方法，包括将本发明化合物的治疗有效量和药学上可接受的载体组合。
• The Effect of the Carbonyl and Related Groups on the Reactivity of Halides in SN2 Reactions
  作者：F. G. Bordwell、W. T. Brannen

  DOI：10.1021/ja01075a025

  日期：1964.11
• Klement, Ingo; Luetjens, Henning; Knochel, Paul, Angewandte Chemie - International Edition in English, 1997, vol. 36, # 13-14, p. 1454 - 1456
  作者：Klement, Ingo、Luetjens, Henning、Knochel, Paul

  DOI：——

  日期：——
• Diastereoselective Synthesis of Tetrahydrofurans from Aryl 3-Chloropropylsulfoxides and Aldehydes
  作者：Zofia Komsta、Michał Barbasiewicz、Mieczysław Ma̧kosza

  DOI：10.1021/jo1002196

  日期：2010.5.21

  Carbanions of aryl 3-chloropropylsulfoxides react with nonenolizable aldehydes to give 2,3-disubstituted tetrahydrofurans. Deprotonation of the sulfoxides carried out in the presence of aldehydes results in the addition of the carbanions to the carbonyl group of the aldehydes, followed by 1,5-intra-molecular substitution of the resulting aldol-type anion to produce the tetrahydrofuran ring. The 2-aryl and 3-arylsulfinyl substituents are always in trans relation, and the reaction proceeds with high diastereoselectivity also in respect to the chiral sulfur atom. The diastereoselectivity is attributed to the cyclic transition state of the aldol addition and increases when the aromatic ring of the sulfoxide contains electron-withdrawing substituents, whereas that of the aldehyde has eleetron-donatine groups.
• .ALPHA.-Fluorination of Methyl Phenyl Sulfoxide and Related Compounds by Molecular Fluorine: A Novel Method for the Introduction of Fluorine into Sulfoxides Bearing .ALPHA.-H Atoms.
  作者：Akemi TOYOTA、Yoshinori ONO、Jun CHIBA、Takumichi SUGIHARA、Chikara KANEKO

  DOI：10.1248/cpb.44.703

  日期：——

  Direct formation of α-fluorosulfones from sulfoxides bearing α-H atoms merely by reaction with molecular fluorine (5% F2/N2) is reported, and a novel non-Pummerer-type mechanism is proposed for this α-fluorination reaction.

  据报道，通过与分子氟（5% F2/N2）反应，仅直接从含有α-H原子的亚砜生成α-氟磺醚，为此α-氟化反应提出了一种新型非Pummerer型机理。