5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(2-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)propan-2-yl)-1H-pyrazole-3-carboxamide | 1331783-79-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(2-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)propan-2-yl)-1H-pyrazole-3-carboxamide
• 英文别名: 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-[2-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]propan-2-yl]pyrazole-3-carboxamide
• CAS: 1331783-79-9
• 化学式: C₂₃H₁₇Cl₃F₃N₅O₂
• 分子量: 558.774
• InChiKey: GUHMEUOIWFHHMS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  36
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  85.8
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(2-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)propan-2-yl)-1H-pyrazole-3-carboxamide 在 N-溴代丁二酰亚胺(NBS) 、 过氧化苯甲酰 作用下， 以 四氯化碳 为溶剂， 反应 14.0h， 以80%的产率得到4-(bromomethyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(2-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)propan-2-yl)-1H-pyrazole-3-carboxamide
  参考文献：
  名称：

  Structure–activity relationship studies of novel pyrazole and imidazole carboxamides as cannabinoid-1 (CB1) antagonists

  摘要：

  The synthesis and biological evaluation of novel pyrazole and imidazole carboxamides as CB1 antagonists are described. As a part of eastern amide SAR, various chemically diverse motifs were introduced on rimonabant template. The central pyrazole core was also replaced with its conformationally constrained motif and imidazole moieties. In general, a range of modifications were well tolerated. Several molecules with low- and sub-nanomolar potencies were identified as potent CB1 receptor antagonists. The in vivo proof of principle for weight loss is demonstrated with a lead compound in DIO mice model. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.06.017
• 作为产物：
  描述：

  5-(4-chlorophenyl)-N-(2-cyanopropan-2-yl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide 在 盐酸羟胺 、 potassium carbonate 作用下， 以 乙醇 为溶剂， 反应 6.0h， 生成 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(2-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)propan-2-yl)-1H-pyrazole-3-carboxamide
  参考文献：
  名称：

  Structure–activity relationship studies of novel pyrazole and imidazole carboxamides as cannabinoid-1 (CB1) antagonists

  摘要：

  The synthesis and biological evaluation of novel pyrazole and imidazole carboxamides as CB1 antagonists are described. As a part of eastern amide SAR, various chemically diverse motifs were introduced on rimonabant template. The central pyrazole core was also replaced with its conformationally constrained motif and imidazole moieties. In general, a range of modifications were well tolerated. Several molecules with low- and sub-nanomolar potencies were identified as potent CB1 receptor antagonists. The in vivo proof of principle for weight loss is demonstrated with a lead compound in DIO mice model. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.06.017

文献信息

• Structure–activity relationship studies of novel pyrazole and imidazole carboxamides as cannabinoid-1 (CB1) antagonists
  作者：Pradip K. Sasmal、Rashmi Talwar、J. Swetha、D. Balasubrahmanyam、B. Venkatesham、Khaji Abdul Rawoof、B. Neelima Devi、Vikram P. Jadhav、Sanjoy K. Khan、Priya Mohan、D. Srinivasa Reddy、Vijay Kumar Nyavanandi、Srinivas Nanduri、K. Shiva Kumar、M. Kannan、P. Srinivas、Prabhakar Nadipalli、Hira Chaudhury、V.J. Sebastian

  DOI：10.1016/j.bmcl.2011.06.017

  日期：2011.8

  The synthesis and biological evaluation of novel pyrazole and imidazole carboxamides as CB1 antagonists are described. As a part of eastern amide SAR, various chemically diverse motifs were introduced on rimonabant template. The central pyrazole core was also replaced with its conformationally constrained motif and imidazole moieties. In general, a range of modifications were well tolerated. Several molecules with low- and sub-nanomolar potencies were identified as potent CB1 receptor antagonists. The in vivo proof of principle for weight loss is demonstrated with a lead compound in DIO mice model. (C) 2011 Elsevier Ltd. All rights reserved.