2-溴-3-氯-5-甲基吡啶 | 65550-81-4

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-溴-3-氯-5-甲基吡啶
• 英文名称: 6-Bromo-5-chloro-3-picolin
• 英文别名: 2-bromo-3-chloro-5-methyl-pyridine；2-Bromo-3-chloro-5-methylpyridine
• CAS: 65550-81-4
• 化学式: C₆H₅BrClN
• 分子量: 206.469
• InChiKey: GNNKEUJOCAJOBW-UHFFFAOYSA-N

物化性质

• 沸点：
  254.5±35.0 °C(Predicted)
• 密度：
  1.624±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2933399090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 2-Bromo-3-chloro-5-methylpyridine
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 2-Bromo-3-chloro-5-methylpyridine
CAS number: 65550-81-4

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C6H5BrClN
Molecular weight: 206.5

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride, hydrogen bromide.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2-溴-3-氯-5-甲基吡啶 在 氯 、 过氧化苯甲酰 作用下， 以 四氯化碳 为溶剂， 反应 8.0h， 生成 2,3-二氯-5-三氯甲基吡啶
  参考文献：
  名称：

  Haga, Takahiro; Fujikawa, Kan-ichi; Koyanagi, Tohru, Heterocycles, 1984, vol. 22, # 1, p. 117 - 124

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氨基-3-氯-5-甲基吡啶 、 氢溴酸 、 sodium hydroxide 以68%的产率得到
  参考文献：
  名称：

  HEILMANN D.; KEMPLER G., WISS. Z. PAED. HOCHSCH. K. LIEBKNECHT POTSDAM, 1980, 24, NO 1, 57-60

  摘要：

  DOI：

文献信息

• 5,6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF AS UROTENSIN II RECEPTOR ANTAGONISTS
  申请人：Altenburger Jean-Michel

  公开号：US20110009426A1

  公开（公告）日：2011-01-13

  The present invention relates to 5,6-bisaryl-2-pyridinecarboxamides, to their preparation and to their therapeutic use as urotensin II receptor antagonists.

  这项发明涉及5,6-双芳基-2-吡啶甲酰胺，以及它们的制备和作为尿苷II受体拮抗剂的治疗用途。
• PIPERIDINE COMPOUNDS AS PCSK9 INHIBITORS
  申请人：SHENZHEN SALUBRIS PHARM CO LTD

  公开号：US20180305346A1

  公开（公告）日：2018-10-25

  One aspect of the invention relates to a series of new PCSK9 inhibitor compounds comprising piperidine ring structures, including compounds of formula (I) and/or pharmaceutically acceptable salts thereof. Another aspect of the invention relates to methods of treating PCSK9 receptor related diseases comprising administration of one or more compounds of formula (I) or a pharmaceutically acceptable salt thereof.

  这项发明的一个方面涉及一系列新的PCSK9抑制剂化合物，包括含有哌啶环结构的化合物，其中包括式(I)的化合物和/或其药用可接受的盐。该发明的另一个方面涉及治疗PCSK9受体相关疾病的方法，包括给予式(I)的一个或多个化合物或其药用可接受的盐。
• BICYCLIC ENAMINO(THIO)CARBONYL COMPOUNDS
  申请人：Jeschke Peter

  公开号：US20090181947A1

  公开（公告）日：2009-07-16

  The present invention relates to novel bicyclic enamino(thio)carbonyl compounds, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in particular insects.

  本发明涉及新颖的双环烯胺基(硫)酰基化合物，以及其制备方法和用于控制动物害虫，特别是节肢动物，尤其是昆虫的用途。
• SUBSTITUTED ENAMINOCARBONYL COMPOUNDS USED AS INSECTICIDES
  申请人：Jeschke Peter

  公开号：US20100240705A1

  公开（公告）日：2010-09-23

  The present application relates to novel substituted enaminocarbonyl compounds, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in particular insects.

  本申请涉及新型取代烯胺羰基化合物，其制备方法以及用于控制动物害虫，特别是节肢动物，尤其是昆虫的用途。
• Synergistic Combinations Of Active Ingredients
  申请人：Jeschke Peter

  公开号：US20120035050A1

  公开（公告）日：2012-02-09

  The present invention relates to novel active compound combinations comprising, firstly, at least one known compound of the formula (I) in which R 1 and A have the meanings given in the description and, secondly, at least one further known active compound from groups (2) to (27) listed in the description, which combinations are highly suitable for controlling animal pests such as insects and unwanted acarids and also phytopathogenic fungi.

  本发明涉及一种新颖的活性化合物组合，首先包括至少一种已知的化合物，其化学式为(I)，其中R1和A具有描述中给出的含义；其次，还包括至少一种来自描述中列出的(2)至(27)组的进一步已知活性化合物，这些组合非常适用于控制动物害虫，如昆虫和不受欢迎的螨虫，以及植物病原真菌。