O-benzyl-L-serine | 52161-82-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: O-benzyl-L-serine
• 英文别名: O-phenyl-L-homoserine；O-Phenyl-L-homoserin；(2S)-2-azaniumyl-4-phenoxybutanoate
• CAS: 52161-82-7
• 化学式: C₁₀H₁₃NO₃
• 分子量: 195.218
• InChiKey: OZTJTXTWPFGIHY-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  O-benzyl-L-serine 在 氢溴酸 作用下， 生成 3-氨基二氢-2(3H)-呋喃酮盐酸盐(1:1)
  参考文献：
  名称：

  D-和L-高丝氨酸的制备。

  摘要：

  DOI：

  10.1021/ja01185a025
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 O-benzyl-L-serine
  参考文献：
  名称：

  D-和L-高丝氨酸的制备。

  摘要：

  DOI：

  10.1021/ja01185a025

文献信息

• HUMAN GLUCAGON-LIKE-PEPTIDE-1 MODULATORS AND THEIR USE IN THE TREATMENT OF DIABETES RELATED CONDITIONS
  申请人：Haque Shamsul Tasir

  公开号：US20070238669A1

  公开（公告）日：2007-10-11

  The present invention provides novel human glucagon-like peptide-1 (GLP-1)-receptor modulators that have biological activity similar or superior to native GLP-1 peptide and thus are useful for the treatment or prevention of diseases or disorders associated with GLP activity. Further, the present invention provides novel, chemically modified compounds that not only stimulate insulin secretion in type II diabetics, but also produce other beneficial insulinotropic responses. These synthetic peptide GLP-1 receptor modulators exhibit increased stability to proteolytic cleavage making them ideal therapeutic candidates for oral or parenteral administration. The compounds of this invention show desirable pharmacokinetic properties and desirable potency in efficacy models of diabetes.

  本发明提供了新型人类胰高血糖素样肽-1（GLP-1）受体调节剂，其生物活性类似或优于天然GLP-1肽，因此可用于治疗或预防与GLP活性相关的疾病或障碍。此外，本发明提供了新的化学修饰化合物，不仅可以刺激2型糖尿病患者的胰岛素分泌，还可以产生其他有益的胰岛素促进反应。这些合成肽GLP-1受体调节剂表现出对蛋白酶水解的稳定性增加，使它们成为口服或静脉注射理想的治疗候选药物。本发明的化合物在糖尿病疗效模型中表现出理想的药代动力学特性和理想的效力。
• Polymer supported oxazolidin-2-ones derived from l-serine—a cautionary tale
  作者：Sean P Bew、Steven D Bull、Stephen G Davies

  DOI：10.1016/s0040-4039(00)01301-0

  日期：2000.9

  The capacity of N-Boc-4-hydroxymethyl-oxazolidin-2-ones to undergo rapid O-O and N-O acyl transfer makes these serine derived chiral auxiliaries unsuitable for attachment to polymers. (C) 2000 Elsevier Science Ltd. All rights reserved.
• HUMAN GLUCAGON-LIKE-PEPTIDE-1 MODULATORS AND THEIR USE IN THE TREATMENT OF DIABETES AND RELATED CONDITIONS
  申请人：Bristol-Myers Squibb Company

  公开号：EP1976873A2

  公开（公告）日：2008-10-08
• NANOFORMULATION OF MUSK-DERIVED BIOACTIVE INGREDIENTS FOR NANOCOSMETIC APPLICATIONS
  申请人：Mousa Shaker A.

  公开号：US20150223451A1

  公开（公告）日：2015-08-13

  The composition of the Nano carrier or Nano polymers composed of Hyaluronic Acid (15-25%) and fatty acids (50-70%) cross linked with ultra-Low molecular weight chitosan (15-25%) encapsulating isolated compounds from musk and their combinations for cosmetic use as anti-aging, anti-microbial, and fragrance. Additionally, these nano-encapsulated Musk bioactive compounds (MBC) at 0.1-10% (w/w MBC/Nano polymers) could be used in textile manufacturing (carpet/rugs and clothes) to provide anti-microbial and fragrance properties. Furthermore, Musk derived products are chemically conjugated to HA polymer, FA polymer, CH polymer, HA-CH co-polymer, FA-CH co-polymer or HA-CH-FA co-polymer to be incorporated into the fabric of the textile products (carpet/rugs or clothes).
• US5578593A
  申请人：——

  公开号：US5578593A

  公开（公告）日：1996-11-26